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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2020-1-1-91-96</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-14</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>ОСОБЕННОСТИ СЕРДЕЧНО-СОСУДИСТЫХ ПОРАЖЕНИЙ ПРИ РЕВМАТОИДНОМ АРТРИТЕ В ЗАВИСИМОСТИ ОТ ВОЗРАСТА ДЕБЮТА ЗАБОЛЕВАНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>FEATURES OF CARDIOVASCULAR LESIONS IN RHEUMATOID ARTHRITIS DEPENDING ON THE AGE OF ONSET OF THE DISEASE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Отарова</surname><given-names>Ж. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Otarova</surname><given-names>Zh. Z.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Krasnodar</p></bio><email xlink:type="simple">zhanna-otarova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеева</surname><given-names>Л. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseeva</surname><given-names>L. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">yeliseyeva@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ждамарова</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhdamarova</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">oijdamar@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдова</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Davidova</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Krasnodar</p></bio><email xlink:type="simple">denisova@3z.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шухардина</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shuchardina</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-кардиолог</p><p>Краснодар </p></bio><bio xml:lang="en"><p>Krasnodar</p></bio><email xlink:type="simple">shelves7@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница № 1 имени профессора С.В. Очаповского» Минздрава Краснодарского края<country>Россия</country></aff><aff xml:lang="en">Scientific Research Institute — S.V.Ochapovsky Regional Clinic Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Kuban State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница № 1 имени профессора С.В. Очаповского» Минздрава Краснодарского края<country>Россия</country></aff><aff xml:lang="en">Scientific Research Institute — S.V.Ochapovsky Regional Clinic Hospita<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">ООО«Сити-Клиник»<country>Россия</country></aff><aff xml:lang="en">«Cyti-Clinics»<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>18</day><month>05</month><year>2020</year></pub-date><volume>1</volume><issue>1</issue><fpage>91</fpage><lpage>96</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Отарова Ж.З., Елисеева Л.Н., Ждамарова О.И., Давыдова А.Ф., Денисова Н.Н., Шухардина Е.Л., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Отарова Ж.З., Елисеева Л.Н., Ждамарова О.И., Давыдова А.Ф., Денисова Н.Н., Шухардина Е.Л.</copyright-holder><copyright-holder xml:lang="en">Otarova Z.Z., Eliseeva L.N., Zhdamarova O.I., Davidova A.F., Denisova N.N., Shuchardina E.L.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/14">https://www.therapeutic-j.ru/jour/article/view/14</self-uri><abstract><sec><title>Цели</title><p>Цели: изучить особенности сердечно-сосудистых поражений у больных ревматоидным артритом (РА) в зависимости от возраста дебюта заболевания. </p></sec><sec><title>Материалы и методы</title><p>Материалы и методы: в исследование включено 140 пациентов с РА. Средний возраст — 53,8 ± 11,2 года, женщин — 82,1 %, мужчин — 17,8 %. В зависимости от возраста дебюта РА, пациенты были разделены на две группы: с дебютом до 45 лет (n = 59) и после 45 лет (n = 81). В группу сравнения включены сопоставимые по гендерному составу и возрасту больные с АГ без РА. </p></sec><sec><title>Результаты</title><p>Результаты: АГ в группе с дебютом РА после 45 лет встречалась чаще, чем в первой группе (57,4 % и 46,6 % соответственно). В I группе только 6,6 % больных имели АГ к моменту дебюта РА, во II — 28,5 %. Во II группе чаще выявлялись такие факторы риска, как избыточная масса тела, ожирение, метаболический синдром. Атеросклеротическая бляшка (АСБ) в сонных артериях во II группе встречались чаще (78,5 %), чем в первой (53,3%). У мужчин и женщин первой группы АСБ встречались с одинаковой частотой, во второй — среди мужчин чаще, чем у женщин (100 % и 71,4% соответственно). </p></sec><sec><title>Заключение</title><p>Заключение: дебют РА после 45 лет чаще сопровождается коморбидностью с АГ в начале заболевания, у них чаще встречаются традиционные факторы риска ССЗ, что ассоциируется с более выраженными структурными изменениями в сонных артериях при сравнении с больными с дебютом РА до 45 лет. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to study the features of cardiovascular lesions in patients with rheumatoid arthritis (RA), depending on the age of diseaseʼs onset. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 140 patients with RA. The average age is 53,8 ± 11,2 years, women 82.1 %, men 17.8 %. Depending on the age of the RA debut, patients are divided into 2 groups: I — patients with a debut of the disease up to 45 years (n = 59) and II — with a debut after 45 years (n = 81). A comparison group consisted of sex and age-comparable patients with essential hypertension without RA. </p></sec><sec><title>Results</title><p>Results: hypertension in the group with RA debut after 45 years was more common than in I group (57.4 % and 46.6 % respectively). In I group, only 6.6 % of patients had hypertension at the time of debut of RA, in the second group — 28.5 %. In the second group the frequency of such traditional risk factors as overweigth and obesity, metabolic syndrome was higher. Atherosclerotic plaques in the carotid arteries in II group were more common (78.5 %) than in I (53.3 %). In the 1st group men and women plaques were found with the same frequency, in the second — among men more often than often women (100 % and 71.4 % respectively). </p></sec><sec><title>Conclusion</title><p>Conclusion: the debut of RA after 45 years is more often associated with hypertension at the onset of the disease, they are more likely to have traditional risk factors, which accompanied by more pronounced structural changes in the carotid arteries when compared with RA debut up to 45 years. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>атеросклероз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>atherosclerosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клиппел Дж. Л., Стоун Дж. Х., Насонова Е.Л. Ревматические заболевания. Том 2. 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