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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><issn pub-type="epub">3033-8344</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2021-2-3-30-39</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-171</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>В лабиринтах патогенеза:  окружающая среда и метаморфозы облика ВЗК</article-title><trans-title-group xml:lang="en"><trans-title>In the labyrinths of pathogenesis: the environment and metamorphosis of IBD</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5554-7084</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ткачев Александр Васильевич, д.м.н., проф., заведующий кафедрой пропедевтики внутренних болезней</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Alexander V. Tkachev, Dr. Sci. (Med.), professor, head of propaedeutics of internal disease</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">tkachev@aaanet.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1820-4488</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мкртчян</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mkrtchyan</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мкртчян Лилит Срапионовна, ассистент кафедры пропедевтики внутренних болезней</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Lilit S. Mkrtchyan, Assistant Professor of department of propaedeutics of internal disease</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">lilit268@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0436-6208</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мазовка</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mazovka</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мазовка Карина Евгеньевна, к.м.н., ассистент кафедры пропедевтики внутренних болезней</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Karina E. Mazovka, Cand. Sci. (Med.), Assistant Professor of department of propaedeutics of internal disease</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">k.mazovka@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боханова</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bohanova</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Боханова Елена Григорьевна, к.м.н., ассистент кафедры пропедевтики внутренних болезней</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Elena G. Bohanova, Cand. Sci. (Med.), Assistant Professor of department of propaedeutics of internal disease</p><p>Rostov-on-Don</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО Ростовский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>29</day><month>08</month><year>2021</year></pub-date><volume>2</volume><issue>3</issue><fpage>30</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ткачев А.В., Мкртчян А.В., Мазовка К.Е., Боханова Е.Г., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Ткачев А.В., Мкртчян А.В., Мазовка К.Е., Боханова Е.Г.</copyright-holder><copyright-holder xml:lang="en">Tkachev A.V., Mkrtchyan L.S., Mazovka K.E., Bohanova E.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/171">https://www.therapeutic-j.ru/jour/article/view/171</self-uri><abstract><p>Цель данного обзора — объединить данные исследований, основанных на оценке влияния окружающей среды на воспалительные заболевания кишечника (ВЗК). В обзоре отражены факторы окружающей среды, оказывающие влияние на заболеваемость ВЗК, а также рассмотрены предикторы, модифицирующие течение заболеваний.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of this review is to combine evidence from studies based on environmental impacts on inflammatory bowel disease. The review reflects the environmental factors influencing the incidence of IBD, and also considers the predictors that modify the course of the diseases.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>язвенный колит</kwd><kwd>воспалительные заболевания кишечника</kwd><kwd>факторы окружающей среды</kwd><kwd>обзор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ulcerative colitis</kwd><kwd>inflammatory bowel disease</kwd><kwd>environmental factors</kwd><kwd>review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ouyang Q, Tandon R, Goh KL, Ooi CJ, Ogata H, Fiocchi C. The emergence of inflammatory bowel disease in the Asian Pacific region. Curr Opin Gastroenterol. 2005;21(4):408-13. PMID: 15930979.</mixed-citation><mixed-citation xml:lang="en">Ouyang Q, Tandon R, Goh KL, Ooi CJ, Ogata H, Fiocchi C. The emergence of inflammatory bowel disease in the Asian Pacific region. Curr Opin Gastroenterol. 2005;21(4):408-13. PMID: 15930979.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Thia KT, Loftus EV Jr, Sandborn WJ, Yang SK. An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol. 2008;103(12):3167-82. doi: 10.1111/j.1572-0241.2008.02158.x</mixed-citation><mixed-citation xml:lang="en">Thia KT, Loftus EV Jr, Sandborn WJ, Yang SK. An update on the epidemiology of inflammatory bowel disease in Asia. Am J Gastroenterol. 2008;103(12):3167-82. doi: 10.1111/j.1572-0241.2008.02158.x</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Румянцев В.Г. Язвенный колит: руководство для врачей. М.: ООО «Медицинское информационное агентство»; 2009. ISBN: 978-5-8948-1777-4</mixed-citation><mixed-citation xml:lang="en">Румянцев В.Г. Язвенный колит: руководство для врачей. М.: ООО «Медицинское информационное агентство»; 2009. ISBN: 978-5-8948-1777-4</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Белоусова Е.А. Язвенный колит и болезнь Крона. Тверь: ООО «Издательство «Триада», 2002. ISBN: 5-94789-015-1</mixed-citation><mixed-citation xml:lang="en">Белоусова Е.А. Язвенный колит и болезнь Крона. Тверь: ООО «Издательство «Триада», 2002. ISBN: 5-94789-015-1</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Дорофеев А.Э., Звягинцева Т.Д., Харченко Н.В. Заболевания кишечника. Горловка: Ліхтар; 2010.</mixed-citation><mixed-citation xml:lang="en">Дорофеев А.Э., Звягинцева Т.Д., Харченко Н.В. Заболевания кишечника. Горловка: Ліхтар; 2010.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Goh K, Xiao SD. Inflammatory bowel disease: a survey of the epidemiology in Asia. J Dig Dis. 2009;10(1):1-6. doi: 10.1111/j.1751-2980.2008.00355.x</mixed-citation><mixed-citation xml:lang="en">Goh K, Xiao SD. Inflammatory bowel disease: a survey of the epidemiology in Asia. J Dig Dis. 2009;10(1):1-6. doi: 10.1111/j.1751-2980.2008.00355.x</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Wang YF, Ouyang Q, Hu RW. Progression of inflammatory bowel disease in China. J Dig Dis. 2010;11(2):76-82. doi: 10.1111/j.1751-2980.2010.00421.x</mixed-citation><mixed-citation xml:lang="en">Wang YF, Ouyang Q, Hu RW. Progression of inflammatory bowel disease in China. J Dig Dis. 2010;11(2):76-82. doi: 10.1111/j.1751-2980.2010.00421.x</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ahuja V, Tandon RK. Inflammatory bowel disease in the Asia-Pacific area: a comparison with developed countries and regional differences. J Dig Dis. 2010;11(3):134-47. doi: 10.1111/j.1751-2980.2010.00429.x</mixed-citation><mixed-citation xml:lang="en">Ahuja V, Tandon RK. Inflammatory bowel disease in the Asia-Pacific area: a comparison with developed countries and regional differences. J Dig Dis. 2010;11(3):134-47. doi: 10.1111/j.1751-2980.2010.00429.x</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Shanahan F. The gut microbiota-a clinical perspective on lessons learned. Nat Rev Gastroenterol Hepatol. 2012;9(10):609-14. doi: 10.1038/nrgastro.2012.145</mixed-citation><mixed-citation xml:lang="en">Shanahan F. The gut microbiota-a clinical perspective on lessons learned. Nat Rev Gastroenterol Hepatol. 2012;9(10):609-14. doi: 10.1038/nrgastro.2012.145</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Mayberry J, Mann R. Inflammatory bowel disease in rural sub-Saharan Africa: rarity of diagnosis in patients attending mission hospitals. Digestion. 1989;44(3):172-6. doi: 10.1159/000199907</mixed-citation><mixed-citation xml:lang="en">Mayberry J, Mann R. Inflammatory bowel disease in rural sub-Saharan Africa: rarity of diagnosis in patients attending mission hospitals. Digestion. 1989;44(3):172-6. doi: 10.1159/000199907</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Soon IS, Molodecky NA, Rabi DM, Ghali WA, Barkema HW, Kaplan GG. The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis. BMC Gastroenterol. 2012;12:51. doi: 10.1186/1471-230X-12-51</mixed-citation><mixed-citation xml:lang="en">Soon IS, Molodecky NA, Rabi DM, Ghali WA, Barkema HW, Kaplan GG. The relationship between urban environment and the inflammatory bowel diseases: a systematic review and meta-analysis. BMC Gastroenterol. 2012;12:51. doi: 10.1186/1471-230X-12-51</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Noverr MC, Huffnagle GB. The ‘microflora hypothesis’ of allergic diseases. Clin Exp Allergy. 2005;35(12):1511-20. doi: 10.1111/j.1365-2222.2005.02379.x</mixed-citation><mixed-citation xml:lang="en">Noverr MC, Huffnagle GB. The ‘microflora hypothesis’ of allergic diseases. Clin Exp Allergy. 2005;35(12):1511-20. doi: 10.1111/j.1365-2222.2005.02379.x</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Leong RW, Mitrev N, Ko Y. Hygiene Hypothesis: Is the Evidence the Same All Over the World? Dig Dis. 2016;34(1-2):35-42. doi: 10.1159/000442922</mixed-citation><mixed-citation xml:lang="en">Leong RW, Mitrev N, Ko Y. Hygiene Hypothesis: Is the Evidence the Same All Over the World? Dig Dis. 2016;34(1-2):35-42. doi: 10.1159/000442922</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Muegge BD, Kuczynski J, Knights D, Clemente JC, González A, Fontana L, et al. Diet drives convergence in gut microлитеРатУРа / rEFErEnCES biome functions across mammalian phylogeny and within humans. Science. 2011;332(6032):970-4. doi: 10.1126/science.1198719</mixed-citation><mixed-citation xml:lang="en">Muegge BD, Kuczynski J, Knights D, Clemente JC, González A, Fontana L, et al. Diet drives convergence in gut microлитеРатУРа / rEFErEnCES biome functions across mammalian phylogeny and within humans. Science. 2011;332(6032):970-4. doi: 10.1126/science.1198719</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011;140(6):1713-9. doi: 10.1053/j.gastro.2011.02.011</mixed-citation><mixed-citation xml:lang="en">Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011;140(6):1713-9. doi: 10.1053/j.gastro.2011.02.011</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Chapman-Kiddell CA, Davies PS, Gillen L, Radford-Smith GL. Role of diet in the development of inflammatory bowel disease. Inflamm Bowel Dis. 2010;16(1):137-51. doi: 10.1002/ibd.20968</mixed-citation><mixed-citation xml:lang="en">Chapman-Kiddell CA, Davies PS, Gillen L, Radford-Smith GL. Role of diet in the development of inflammatory bowel disease. Inflamm Bowel Dis. 2010;16(1):137-51. doi: 10.1002/ibd.20968</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol. 2011;106(4):563-73. doi: 10.1038/ajg.2011.44</mixed-citation><mixed-citation xml:lang="en">Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol. 2011;106(4):563-73. doi: 10.1038/ajg.2011.44</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ma X, Torbenson M, Hamad AR, Soloski MJ, Li Z. High-fat diet modulates non-CD1d-restricted natural killer T cells and regulatory T cells in mouse colon and exacerbates experimental colitis. Clin Exp Immunol. 2008;151(1):130-8. doi: 10.1111/j.1365-2249.2007.03530.x</mixed-citation><mixed-citation xml:lang="en">Ma X, Torbenson M, Hamad AR, Soloski MJ, Li Z. High-fat diet modulates non-CD1d-restricted natural killer T cells and regulatory T cells in mouse colon and exacerbates experimental colitis. Clin Exp Immunol. 2008;151(1):130-8. doi: 10.1111/j.1365-2249.2007.03530.x</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, et al. A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis. Gastroenterology. 2013;145(5):970-7. doi: 10.1053/j.gastro.2013.07.050</mixed-citation><mixed-citation xml:lang="en">Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, et al. A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis. Gastroenterology. 2013;145(5):970-7. doi: 10.1053/j.gastro.2013.07.050</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Rodríguez-Cabezas ME, Gálvez J, Camuesco D, Lorente MD, Concha A, Martinez-Augustin O, et al. Intestinal anti-inflammatory activity of dietary fiber (Plantago ovata seeds) in HLA-B27 transgenic rats. Clin Nutr. 2003;22(5):463-71. doi: 10.1016/s0261-5614(03)00045-1</mixed-citation><mixed-citation xml:lang="en">Rodríguez-Cabezas ME, Gálvez J, Camuesco D, Lorente MD, Concha A, Martinez-Augustin O, et al. Intestinal anti-inflammatory activity of dietary fiber (Plantago ovata seeds) in HLA-B27 transgenic rats. Clin Nutr. 2003;22(5):463-71. doi: 10.1016/s0261-5614(03)00045-1</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Fernández-Bañares F, Hinojosa J, Sánchez-Lombraña JL, Navarro E, Martínez-Salmerón JF, García-Pugés A, et al. Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn’s Disease and Ulcerative Colitis (GETECCU). Am J Gastroenterol. 1999;94(2):427-33. doi: 10.1111/j.1572-0241.1999.872_a.x</mixed-citation><mixed-citation xml:lang="en">Fernández-Bañares F, Hinojosa J, Sánchez-Lombraña JL, Navarro E, Martínez-Salmerón JF, García-Pugés A, et al. Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn’s Disease and Ulcerative Colitis (GETECCU). Am J Gastroenterol. 1999;94(2):427-33. doi: 10.1111/j.1572-0241.1999.872_a.x</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Ситкин С.И., Ткаченко Е.И., Вахитов Т.Я., Орешко Л.С., Жигалова Т.Н. Особенности метаболома сыворотки крови при язвенном колите и целиакии по данным газовой хроматографии – масс-спектрометрии. Гастроэнтерология Санкт-Петербурга. 2013;3-4:2-10. eLIBRARY ID: 29730010</mixed-citation><mixed-citation xml:lang="en">Ситкин С.И., Ткаченко Е.И., Вахитов Т.Я., Орешко Л.С., Жигалова Т.Н. Особенности метаболома сыворотки крови при язвенном колите и целиакии по данным газовой хроматографии – масс-спектрометрии. Гастроэнтерология Санкт-Петербурга. 2013;3-4:2-10. eLIBRARY ID: 29730010</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Higuchi LM, Khalili H, Chan AT, Richter JM, Bousvaros A, Fuchs CS. A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women. Am J Gastroenterol. 2012;107(9):1399-406. doi: 10.1038/ajg.2012.196</mixed-citation><mixed-citation xml:lang="en">Higuchi LM, Khalili H, Chan AT, Richter JM, Bousvaros A, Fuchs CS. A prospective study of cigarette smoking and the risk of inflammatory bowel disease in women. Am J Gastroenterol. 2012;107(9):1399-406. doi: 10.1038/ajg.2012.196</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson GJ, Cosnes J, Mansfield JC. Review article: smoking cessation as primary therapy to modify the course of Crohn’s disease. Aliment Pharmacol Ther. 2005;21(8):921-31. doi: 10.1111/j.1365-2036.2005.02424.x</mixed-citation><mixed-citation xml:lang="en">Johnson GJ, Cosnes J, Mansfield JC. Review article: smoking cessation as primary therapy to modify the course of Crohn’s disease. Aliment Pharmacol Ther. 2005;21(8):921-31. doi: 10.1111/j.1365-2036.2005.02424.x</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mahid SS, Minor KS, Soto RE, Hornung CA, Galandiuk S. Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clin Proc. 2006;81(11):1462-71. doi: 10.4065/81.11.1462</mixed-citation><mixed-citation xml:lang="en">Mahid SS, Minor KS, Soto RE, Hornung CA, Galandiuk S. Smoking and inflammatory bowel disease: a meta-analysis. Mayo Clin Proc. 2006;81(11):1462-71. doi: 10.4065/81.11.1462</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Cosnes J, Nion-Larmurier I, Afchain P, Beaugerie L, Gendre JP. Gender differences in the response of colitis to smoking. Clin Gastroenterol Hepatol. 2004;2(1):41-8. doi: 10.1016/s1542-3565(03)00290-8</mixed-citation><mixed-citation xml:lang="en">Cosnes J, Nion-Larmurier I, Afchain P, Beaugerie L, Gendre JP. Gender differences in the response of colitis to smoking. Clin Gastroenterol Hepatol. 2004;2(1):41-8. doi: 10.1016/s1542-3565(03)00290-8</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Louis E, Michel V, Hugot JP, Reenaers C, Fontaine F, Delforge M, et al. Early development of stricturing or penetrating pattern in Crohn’s disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype. Gut. 2003;52(4):552-7. doi: 10.1136/gut.52.4.552</mixed-citation><mixed-citation xml:lang="en">Louis E, Michel V, Hugot JP, Reenaers C, Fontaine F, Delforge M, et al. Early development of stricturing or penetrating pattern in Crohn’s disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype. Gut. 2003;52(4):552-7. doi: 10.1136/gut.52.4.552</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nunes T, Etchevers MJ, Merino O, Gallego S, García-Sánchez V, Marín-Jiménez I, et al. High smoking cessation rate in Crohn’s disease patients after physician advice--the TABACROHN Study. J Crohns Colitis. 2013;7(3):202-7. doi: 10.1016/j.crohns.2012.04.011</mixed-citation><mixed-citation xml:lang="en">Nunes T, Etchevers MJ, Merino O, Gallego S, García-Sánchez V, Marín-Jiménez I, et al. High smoking cessation rate in Crohn’s disease patients after physician advice--the TABACROHN Study. J Crohns Colitis. 2013;7(3):202-7. doi: 10.1016/j.crohns.2012.04.011</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mokbel M, Carbonnel F, Beaugerie L, Gendre JP, Cosnes J. Effet du tabac sur l’évolution à long terme de la rectocolite hémorragique [Effect of smoking on the long-term course of ulcerative colitis]. Gastroenterol Clin Biol. 1998;22(11):858-62. (In French). PMID: 9881267.</mixed-citation><mixed-citation xml:lang="en">Mokbel M, Carbonnel F, Beaugerie L, Gendre JP, Cosnes J. Effet du tabac sur l’évolution à long terme de la rectocolite hémorragique [Effect of smoking on the long-term course of ulcerative colitis]. Gastroenterol Clin Biol. 1998;22(11):858-62. (In French). PMID: 9881267.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gisbert JP, Marín AC, Chaparro M. Systematic review: factors associated with relapse of inflammatory bowel disease after discontinuation of anti-TNF therapy. Aliment Pharmacol Ther. 2015;42(4):391-405. doi: 10.1111/apt.13276</mixed-citation><mixed-citation xml:lang="en">Gisbert JP, Marín AC, Chaparro M. Systematic review: factors associated with relapse of inflammatory bowel disease after discontinuation of anti-TNF therapy. Aliment Pharmacol Ther. 2015;42(4):391-405. doi: 10.1111/apt.13276</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Höie O, Wolters F, Riis L, Aamodt G, Solberg C, Bernklev T, et al. Ulcerative colitis: patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. Am J Gastroenterol. 2007;102(8):1692-701. doi: 10.1111/j.1572-0241.2007.01265.x</mixed-citation><mixed-citation xml:lang="en">Höie O, Wolters F, Riis L, Aamodt G, Solberg C, Bernklev T, et al. Ulcerative colitis: patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. Am J Gastroenterol. 2007;102(8):1692-701. doi: 10.1111/j.1572-0241.2007.01265.x</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Фарелл Р., Пепперкорн М. Язвенный колит. Международный медицинский журнал. 2003;6(1):73-80.</mixed-citation><mixed-citation xml:lang="en">Фарелл Р., Пепперкорн М. Язвенный колит. Международный медицинский журнал. 2003;6(1):73-80.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hu D, Ren J, Wang G, Gu G, Liu S, Wu X, et al. Geographic mapping of Crohn’s disease and its relation to affluence in jiangsu province, an eastern coastal province of china. Gastroenterol Res Pract. 2014;2014:590467. doi: 10.1155/2014/590467</mixed-citation><mixed-citation xml:lang="en">Hu D, Ren J, Wang G, Gu G, Liu S, Wu X, et al. Geographic mapping of Crohn’s disease and its relation to affluence in jiangsu province, an eastern coastal province of china. Gastroenterol Res Pract. 2014;2014:590467. doi: 10.1155/2014/590467</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan GG, Hubbard J, Korzenik J, Sands BE, Panaccione R, Ghosh S, et al. The inflammatory bowel diseases and ambient air pollution: a novel association. Am J Gastroenterol. 2010;105(11):2412-9. doi: 10.1038/ajg.2010.252</mixed-citation><mixed-citation xml:lang="en">Kaplan GG, Hubbard J, Korzenik J, Sands BE, Panaccione R, Ghosh S, et al. The inflammatory bowel diseases and ambient air pollution: a novel association. Am J Gastroenterol. 2010;105(11):2412-9. doi: 10.1038/ajg.2010.252</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Salim SY, Kaplan GG, Madsen KL. Air pollution effects on the gut microbiota: a link between exposure and inflammatory disease. Gut Microbes. 2014;5(2):215-9. doi: 10.4161/gmic.27251</mixed-citation><mixed-citation xml:lang="en">Salim SY, Kaplan GG, Madsen KL. Air pollution effects on the gut microbiota: a link between exposure and inflammatory disease. Gut Microbes. 2014;5(2):215-9. doi: 10.4161/gmic.27251</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Vedani A, Smiesko M, Spreafico M, Peristera O, Dobler M. VirtualToxLab - in silico prediction of the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. Two years and 2,000 compounds of experience: a progress report. ALTEX. 2009;26(3):167-76. doi: 10.14573/altex.2009.3.167</mixed-citation><mixed-citation xml:lang="en">Vedani A, Smiesko M, Spreafico M, Peristera O, Dobler M. VirtualToxLab - in silico prediction of the toxic (endocrine-disrupting) potential of drugs, chemicals and natural products. Two years and 2,000 compounds of experience: a progress report. ALTEX. 2009;26(3):167-76. doi: 10.14573/altex.2009.3.167</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Wagner M, Schlüsener MP, Ternes TA, Oehlmann J. Identification of putative steroid receptor antagonists in bottled water: combining bioassays and high-resolution mass spectrometry. PLoS One. 2013;8(8):e72472. doi: 10.1371/journal.pone.0072472</mixed-citation><mixed-citation xml:lang="en">Wagner M, Schlüsener MP, Ternes TA, Oehlmann J. Identification of putative steroid receptor antagonists in bottled water: combining bioassays and high-resolution mass spectrometry. PLoS One. 2013;8(8):e72472. doi: 10.1371/journal.pone.0072472</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Benchimol EI, Mack DR, Guttmann A, Nguyen GC, To T, Mojaverian N, et al. Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study. Am J Gastroenterol. 2015;110(4):553-63. doi: 10.1038/ajg.2015.52</mixed-citation><mixed-citation xml:lang="en">Benchimol EI, Mack DR, Guttmann A, Nguyen GC, To T, Mojaverian N, et al. Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study. Am J Gastroenterol. 2015;110(4):553-63. doi: 10.1038/ajg.2015.52</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bernstein CN, Kraut A, Blanchard JF, Rawsthorne P, Yu N, Walld R. The relationship between inflammatory bowel disease and socioeconomic variables. Am J Gastroenterol. 2001;96(7):2117-25. doi: 10.1111/j.1572-0241.2001.03946.x</mixed-citation><mixed-citation xml:lang="en">Bernstein CN, Kraut A, Blanchard JF, Rawsthorne P, Yu N, Walld R. The relationship between inflammatory bowel disease and socioeconomic variables. Am J Gastroenterol. 2001;96(7):2117-25. doi: 10.1111/j.1572-0241.2001.03946.x</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Declercq C, Gower-Rousseau C, Vernier-Massouille G, Salleron J, Baldé M, Poirier G, et al. Mapping of inflammatory bowel disease in northern France: spatial variations and relation to affluence. Inflamm Bowel Dis. 2010;16(5):807-12. doi: 10.1002/ibd.21111</mixed-citation><mixed-citation xml:lang="en">Declercq C, Gower-Rousseau C, Vernier-Massouille G, Salleron J, Baldé M, Poirier G, et al. Mapping of inflammatory bowel disease in northern France: spatial variations and relation to affluence. Inflamm Bowel Dis. 2010;16(5):807-12. doi: 10.1002/ibd.21111</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng JJ, Zhu XS, Huangfu Z, Gao ZX, Guo ZR, Wang Z. Crohn’s disease in mainland China: a systematic analysis of 50 years of research. Chin J Dig Dis. 2005;6(4):175-81. doi: 10.1111/j.1443-9573.2005.00227.x</mixed-citation><mixed-citation xml:lang="en">Zheng JJ, Zhu XS, Huangfu Z, Gao ZX, Guo ZR, Wang Z. Crohn’s disease in mainland China: a systematic analysis of 50 years of research. Chin J Dig Dis. 2005;6(4):175-81. doi: 10.1111/j.1443-9573.2005.00227.x</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hviid A, Svanström H, Frisch M. Antibiotic use and inflammatory bowel diseases in childhood. Gut. 2011;60(1):49-54. doi: 10.1136/gut.2010.219683</mixed-citation><mixed-citation xml:lang="en">Hviid A, Svanström H, Frisch M. Antibiotic use and inflammatory bowel diseases in childhood. Gut. 2011;60(1):49-54. doi: 10.1136/gut.2010.219683</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Ballegaard M, Bjergstrøm A, Brøndum S, Hylander E, Jensen L, Ladefoged K. Self-reported food intolerance in chronic inflammatory bowel disease. Scand J Gastroenterol. 1997;32(6):569-71. doi: 10.3109/00365529709025101</mixed-citation><mixed-citation xml:lang="en">Ballegaard M, Bjergstrøm A, Brøndum S, Hylander E, Jensen L, Ladefoged K. Self-reported food intolerance in chronic inflammatory bowel disease. Scand J Gastroenterol. 1997;32(6):569-71. doi: 10.3109/00365529709025101</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sokol H, Seksik P, Furet JP, Firmesse O, Nion-Larmurier I, Beaugerie L, et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis. 2009;15(8):1183-9. doi: 10.1002/ibd.20903</mixed-citation><mixed-citation xml:lang="en">Sokol H, Seksik P, Furet JP, Firmesse O, Nion-Larmurier I, Beaugerie L, et al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis. 2009;15(8):1183-9. doi: 10.1002/ibd.20903</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105(43):16731-6. doi: 10.1073/pnas.0804812105</mixed-citation><mixed-citation xml:lang="en">Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105(43):16731-6. doi: 10.1073/pnas.0804812105</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Chassaing B, Darfeuille-Michaud A. The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1720-28. doi: 10.1053/j.gastro.2011.01.054</mixed-citation><mixed-citation xml:lang="en">Chassaing B, Darfeuille-Michaud A. The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140(6):1720-28. doi: 10.1053/j.gastro.2011.01.054</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134(2):577-94. doi: 10.1053/j.gastro.2007.11.059</mixed-citation><mixed-citation xml:lang="en">Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134(2):577-94. doi: 10.1053/j.gastro.2007.11.059</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, et al. Commensal-dependent expression of IL-25 regulates the IL-23 -IL-17 axis in the intestine. J Exp Med. 2008;205(10):2191-8. doi: 10.1084/jem.20080720</mixed-citation><mixed-citation xml:lang="en">Zaph C, Du Y, Saenz SA, Nair MG, Perrigoue JG, Taylor BC, et al. Commensal-dependent expression of IL-25 regulates the IL-23 -IL-17 axis in the intestine. J Exp Med. 2008;205(10):2191-8. doi: 10.1084/jem.20080720</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Jess T, Simonsen J, Nielsen NM, Jørgensen KT, Bager P, Ethelberg S, et al. Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease. Gut. 2011;60(3):318-24. doi: 10.1136/gut.2010.223396</mixed-citation><mixed-citation xml:lang="en">Jess T, Simonsen J, Nielsen NM, Jørgensen KT, Bager P, Ethelberg S, et al. Enteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease. Gut. 2011;60(3):318-24. doi: 10.1136/gut.2010.223396</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Jodorkovsky D, Young Y, Abreu MT. Clinical outcomes of patients with ulcerative colitis and co-existing Clostridium difficile infection. Dig Dis Sci. 2010;55(2):415-20. doi: 10.1007/s10620-009-0749-9</mixed-citation><mixed-citation xml:lang="en">Jodorkovsky D, Young Y, Abreu MT. Clinical outcomes of patients with ulcerative colitis and co-existing Clostridium difficile infection. Dig Dis Sci. 2010;55(2):415-20. doi: 10.1007/s10620-009-0749-9</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Naser SA, Sagramsingh SR, Naser AS, Thanigachalam S. Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients. World J Gastroenterol. 2014;20(23):7403-15. doi: 10.3748/wjg.v20.i23.7403</mixed-citation><mixed-citation xml:lang="en">Naser SA, Sagramsingh SR, Naser AS, Thanigachalam S. Mycobacterium avium subspecies paratuberculosis causes Crohn’s disease in some inflammatory bowel disease patients. World J Gastroenterol. 2014;20(23):7403-15. doi: 10.3748/wjg.v20.i23.7403</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Criscuoli V, Rizzuto MR, Cottone M. Cytomegalovirus and inflammatory bowel disease: is there a link? World J Gastroenterol. 2006;12(30):4813-8. doi: 10.3748/wjg.v12.i30.4813</mixed-citation><mixed-citation xml:lang="en">Criscuoli V, Rizzuto MR, Cottone M. Cytomegalovirus and inflammatory bowel disease: is there a link? World J Gastroenterol. 2006;12(30):4813-8. doi: 10.3748/wjg.v12.i30.4813</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Kim JJ, Simpson N, Klipfel N, Debose R, Barr N, Laine L. Cytomegalovirus infection in patients with active inflammatory bowel disease. Dig Dis Sci. 2010;55(4):1059-65. doi: 10.1007/s10620-010-1126-4</mixed-citation><mixed-citation xml:lang="en">Kim JJ, Simpson N, Klipfel N, Debose R, Barr N, Laine L. Cytomegalovirus infection in patients with active inflammatory bowel disease. Dig Dis Sci. 2010;55(4):1059-65. doi: 10.1007/s10620-010-1126-4</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Sankaran-Walters S, Ransibrahmanakul K, Grishina I, Hung J, Martinez E, Prindiville T, et al. Epstein-Barr virus replication linked to B cell proliferation in inflamed areas of colonic mucosa of patients with inflammatory bowel disease. J Clin Virol. 2011;50(1):31-6. doi: 10.1016/j.jcv.2010.09.011</mixed-citation><mixed-citation xml:lang="en">Sankaran-Walters S, Ransibrahmanakul K, Grishina I, Hung J, Martinez E, Prindiville T, et al. Epstein-Barr virus replication linked to B cell proliferation in inflamed areas of colonic mucosa of patients with inflammatory bowel disease. J Clin Virol. 2011;50(1):31-6. doi: 10.1016/j.jcv.2010.09.011</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Schunter MO, Walles T, Fritz P, Meyding-Lamadé U, Thon KP, Fellermann K, et al. Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections. J Crohns Colitis. 2007;1(1):41-6. doi: 10.1016/j.crohns.2007.06.004</mixed-citation><mixed-citation xml:lang="en">Schunter MO, Walles T, Fritz P, Meyding-Lamadé U, Thon KP, Fellermann K, et al. Herpes simplex virus colitis complicating ulcerative colitis: A case report and brief review on superinfections. J Crohns Colitis. 2007;1(1):41-6. doi: 10.1016/j.crohns.2007.06.004</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Weinstock JV, Elliott DE. Helminths and the IBD hygiene hypothesis. Inflamm Bowel Dis. 2009;15(1):128-33. doi: 10.1002/ibd.20633</mixed-citation><mixed-citation xml:lang="en">Weinstock JV, Elliott DE. Helminths and the IBD hygiene hypothesis. Inflamm Bowel Dis. 2009;15(1):128-33. doi: 10.1002/ibd.20633</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Kabeerdoss J, Pugazhendhi S, Subramanian V, Binder HJ, Ramakrishna BS. Exposure to hookworms in patients with Crohn’s disease: a case-control study. Aliment Pharmacol Ther. 2011;34(8):923-30. doi: 10.1111/j.1365-2036.2011.04824.x</mixed-citation><mixed-citation xml:lang="en">Kabeerdoss J, Pugazhendhi S, Subramanian V, Binder HJ, Ramakrishna BS. Exposure to hookworms in patients with Crohn’s disease: a case-control study. Aliment Pharmacol Ther. 2011;34(8):923-30. doi: 10.1111/j.1365-2036.2011.04824.x</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Sandborn WJ, Elliott DE, Weinstock J, Summers RW, LandryWheeler A, Silver N, et al. Randomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn’s disease. Aliment Pharmacol Ther. 2013;38(3):255-63. doi: 10.1111/apt.12366</mixed-citation><mixed-citation xml:lang="en">Sandborn WJ, Elliott DE, Weinstock J, Summers RW, LandryWheeler A, Silver N, et al. Randomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn’s disease. Aliment Pharmacol Ther. 2013;38(3):255-63. doi: 10.1111/apt.12366</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Garg SK, Croft AM, Bager P. Helminth therapy (worms) for induction of remission in inflammatory bowel disease. Cochrane Database Syst Rev. 2014;(1):CD009400. doi: 10.1002/14651858.CD009400.pub2.</mixed-citation><mixed-citation xml:lang="en">Garg SK, Croft AM, Bager P. Helminth therapy (worms) for induction of remission in inflammatory bowel disease. Cochrane Database Syst Rev. 2014;(1):CD009400. doi: 10.1002/14651858.CD009400.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Abegunde AT, Muhammad BH, Bhatti O, Ali T. Environmental risk factors for inflammatory bowel diseases: Evidence based literature review. World J Gastroenterol. 2016;22(27):6296-317. doi: 10.3748/wjg.v22.i27.6296</mixed-citation><mixed-citation xml:lang="en">Abegunde AT, Muhammad BH, Bhatti O, Ali T. Environmental risk factors for inflammatory bowel diseases: Evidence based literature review. World J Gastroenterol. 2016;22(27):6296-317. doi: 10.3748/wjg.v22.i27.6296</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Bonner GF, Fakhri A, Vennamaneni SR. A long-term cohort study of nonsteroidal anti-inflammatory drug use and disease activity in outpatients with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10(6):751-7. doi: 10.1097/00054725-200411000-00009</mixed-citation><mixed-citation xml:lang="en">Bonner GF, Fakhri A, Vennamaneni SR. A long-term cohort study of nonsteroidal anti-inflammatory drug use and disease activity in outpatients with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10(6):751-7. doi: 10.1097/00054725-200411000-00009</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Takeuchi K, Smale S, Premchand P, Maiden L, Sherwood R, Thjodleifsson B, et al. Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2006;4(2):196-202. doi: 10.1016/s1542-3565(05)00980-8</mixed-citation><mixed-citation xml:lang="en">Takeuchi K, Smale S, Premchand P, Maiden L, Sherwood R, Thjodleifsson B, et al. Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2006;4(2):196-202. doi: 10.1016/s1542-3565(05)00980-8</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Matuk R, Crawford J, Abreu MT, Targan SR, Vasiliauskas EA, Papadakis KA. The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10(4):352-6. doi: 10.1097/00054725-200407000-00005</mixed-citation><mixed-citation xml:lang="en">Matuk R, Crawford J, Abreu MT, Targan SR, Vasiliauskas EA, Papadakis KA. The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2004;10(4):352-6. doi: 10.1097/00054725-200407000-00005</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Mahadevan U, Loftus EV Jr, Tremaine WJ, Sandborn WJ. Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease. Am J Gastroenterol. 2002;97(4):910-4. doi: 10.1111/j.1572-0241.2002.05608.x</mixed-citation><mixed-citation xml:lang="en">Mahadevan U, Loftus EV Jr, Tremaine WJ, Sandborn WJ. Safety of selective cyclooxygenase-2 inhibitors in inflammatory bowel disease. Am J Gastroenterol. 2002;97(4):910-4. doi: 10.1111/j.1572-0241.2002.05608.x</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw SY, Blanchard JF, Bernstein CN. Association between the use of antibiotics and new diagnoses of Crohn’s disease and ulcerative colitis. Am J Gastroenterol. 2011;106(12):2133-42. doi: 10.1038/ajg.2011.304</mixed-citation><mixed-citation xml:lang="en">Shaw SY, Blanchard JF, Bernstein CN. Association between the use of antibiotics and new diagnoses of Crohn’s disease and ulcerative colitis. Am J Gastroenterol. 2011;106(12):2133-42. doi: 10.1038/ajg.2011.304</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Ungaro R, Bernstein CN, Gearry R, Hviid A, Kolho KL, Kronman MP, et al. Antibiotics associated with increased risk of new-onset Crohn’s disease but not ulcerative colitis: a metaanalysis. Am J Gastroenterol. 2014;109(11):1728-38. doi: 10.1038/ajg.2014.246</mixed-citation><mixed-citation xml:lang="en">Ungaro R, Bernstein CN, Gearry R, Hviid A, Kolho KL, Kronman MP, et al. Antibiotics associated with increased risk of new-onset Crohn’s disease but not ulcerative colitis: a metaanalysis. Am J Gastroenterol. 2014;109(11):1728-38. doi: 10.1038/ajg.2014.246</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Hildebrand H, Malmborg P, Askling J, Ekbom A, Montgomery SM. Early-life exposures associated with antibiotic use and risk of subsequent Crohn’s disease. Scand J Gastroenterol. 2008;43(8):961-6. doi: 10.1080/00365520801971736</mixed-citation><mixed-citation xml:lang="en">Hildebrand H, Malmborg P, Askling J, Ekbom A, Montgomery SM. Early-life exposures associated with antibiotic use and risk of subsequent Crohn’s disease. Scand J Gastroenterol. 2008;43(8):961-6. doi: 10.1080/00365520801971736</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Khan KJ, Ullman TA, Ford AC, Abreu MT, Abadir A, Marshall JK, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):661-73. doi: 10.1038/ajg.2011.72</mixed-citation><mixed-citation xml:lang="en">Khan KJ, Ullman TA, Ford AC, Abreu MT, Abadir A, Marshall JK, et al. Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis. Am J Gastroenterol. 2011;106(4):661-73. doi: 10.1038/ajg.2011.72</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Rutgeerts P, Van Assche G, Vermeire S, D’Haens G, Baert F, Noman M, Aerden I, et al. Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005;128(4):856-61. doi: 10.1053/j.gastro.2005.01.010</mixed-citation><mixed-citation xml:lang="en">Rutgeerts P, Van Assche G, Vermeire S, D’Haens G, Baert F, Noman M, Aerden I, et al. Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2005;128(4):856-61. doi: 10.1053/j.gastro.2005.01.010</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Cornish JA, Tan E, Simillis C, Clark SK, Teare J, Tekkis PP. The risk of oral contraceptives in the etiology of inflammatory bowel disease: a meta-analysis. Am J Gastroenterol. 2008;103(9):2394-400. doi: 10.1111/j.1572-0241.2008.02064.x</mixed-citation><mixed-citation xml:lang="en">Cornish JA, Tan E, Simillis C, Clark SK, Teare J, Tekkis PP. The risk of oral contraceptives in the etiology of inflammatory bowel disease: a meta-analysis. Am J Gastroenterol. 2008;103(9):2394-400. doi: 10.1111/j.1572-0241.2008.02064.x</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Khalili H, Higuchi LM, Ananthakrishnan AN, Richter JM, Feskanich D, Fuchs CS, et al. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut. 2013;62(8):1153-9. doi: 10.1136/gutjnl-2012-302362</mixed-citation><mixed-citation xml:lang="en">Khalili H, Higuchi LM, Ananthakrishnan AN, Richter JM, Feskanich D, Fuchs CS, et al. Oral contraceptives, reproductive factors and risk of inflammatory bowel disease. Gut. 2013;62(8):1153-9. doi: 10.1136/gutjnl-2012-302362</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Khalili H, Higuchi LM, Ananthakrishnan AN, Manson JE, Feskanich D, Richter JM, et al. Hormone therapy increases risk of ulcerative colitis but not Crohn’s disease. Gastroenterology. 2012;143(5):1199-1206. doi: 10.1053/j.gastro.2012.07.096</mixed-citation><mixed-citation xml:lang="en">Khalili H, Higuchi LM, Ananthakrishnan AN, Manson JE, Feskanich D, Richter JM, et al. Hormone therapy increases risk of ulcerative colitis but not Crohn’s disease. Gastroenterology. 2012;143(5):1199-1206. doi: 10.1053/j.gastro.2012.07.096</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Timmer A, Sutherland LR, Martin F. Oral contraceptive use and smoking are risk factors for relapse in Crohn’s disease. The Canadian Mesalamine for Remission of Crohn’s Disease Study Group. Gastroenterology. 1998;114(6):1143-50. doi: 10.1016/s0016-5085(98)70419-6</mixed-citation><mixed-citation xml:lang="en">Timmer A, Sutherland LR, Martin F. Oral contraceptive use and smoking are risk factors for relapse in Crohn’s disease. The Canadian Mesalamine for Remission of Crohn’s Disease Study Group. Gastroenterology. 1998;114(6):1143-50. doi: 10.1016/s0016-5085(98)70419-6</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci. 2006;1089:538-47. doi: 10.1196/annals.1386.043</mixed-citation><mixed-citation xml:lang="en">Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci. 2006;1089:538-47. doi: 10.1196/annals.1386.043</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004;229(11):1136-42. doi: 10.1177/153537020422901108</mixed-citation><mixed-citation xml:lang="en">Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood). 2004;229(11):1136-42. doi: 10.1177/153537020422901108</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Yang L, Weaver V, Smith JP, Bingaman S, Hartman TJ, Cantorna MT. Therapeutic effect of vitamin d supplementation in a pilot study of Crohn’s patients. Clin Transl Gastroenterol. 2013;4(4):e33. doi: 10.1038/ctg.2013.1</mixed-citation><mixed-citation xml:lang="en">Yang L, Weaver V, Smith JP, Bingaman S, Hartman TJ, Cantorna MT. Therapeutic effect of vitamin d supplementation in a pilot study of Crohn’s patients. Clin Transl Gastroenterol. 2013;4(4):e33. doi: 10.1038/ctg.2013.1</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr. 2011;35(3):308-16. doi: 10.1177/0148607110381267</mixed-citation><mixed-citation xml:lang="en">Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG, et al. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr. 2011;35(3):308-16. doi: 10.1177/0148607110381267</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Jørgensen SP, Agnholt J, Glerup H, Lyhne S, Villadsen GE, Hvas CL, et al. Clinical trial: vitamin D3 treatment in Crohn’s disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. 2010;32(3):377-83. doi: 10.1111/j.1365-2036.2010.04355.x</mixed-citation><mixed-citation xml:lang="en">Jørgensen SP, Agnholt J, Glerup H, Lyhne S, Villadsen GE, Hvas CL, et al. Clinical trial: vitamin D3 treatment in Crohn’s disease - a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther. 2010;32(3):377-83. doi: 10.1111/j.1365-2036.2010.04355.x</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347(12):911-20. doi: 10.1056/NEJMra020100</mixed-citation><mixed-citation xml:lang="en">Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med. 2002;347(12):911-20. doi: 10.1056/NEJMra020100</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Baron S, Turck D, Leplat C, Merle V, Gower-Rousseau C, Marti R, et al. Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study. Gut. 2005;54(3):357-63. doi: 10.1136/gut.2004.054353</mixed-citation><mixed-citation xml:lang="en">Baron S, Turck D, Leplat C, Merle V, Gower-Rousseau C, Marti R, et al. Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study. Gut. 2005;54(3):357-63. doi: 10.1136/gut.2004.054353</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Дорофеев А.Э. Диагностика и лечение заболеваний пищеварительного тракта. Донецк: Норд¬Пресс; 2009. ISBN: 978-966-380-283-1</mixed-citation><mixed-citation xml:lang="en">Дорофеев А.Э. Диагностика и лечение заболеваний пищеварительного тракта. Донецк: Норд¬Пресс; 2009. ISBN: 978-966-380-283-1</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Russel MG, Dorant E, Brummer RJ, van de Kruijs MA, Muris JW, Bergers JM, et al. Appendectomy and the risk of developing ulcerative colitis or Crohn’s disease: results of a large casecontrol study. South Limburg Inflammatory Bowel Disease Study Group. Gastroenterology. 1997;113(2):377-82. doi: 10.1053/gast.1997.v113.pm9247453</mixed-citation><mixed-citation xml:lang="en">Russel MG, Dorant E, Brummer RJ, van de Kruijs MA, Muris JW, Bergers JM, et al. Appendectomy and the risk of developing ulcerative colitis or Crohn’s disease: results of a large casecontrol study. South Limburg Inflammatory Bowel Disease Study Group. Gastroenterology. 1997;113(2):377-82. doi: 10.1053/gast.1997.v113.pm9247453</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty T, Rotter JI. Increased intestinal permeability in patients with Crohn’s disease and their relatives. A possible etiologic factor. Ann Intern Med. 1986;105(6):883-5. doi: 10.7326/0003-4819-105-6-883.</mixed-citation><mixed-citation xml:lang="en">Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty T, Rotter JI. Increased intestinal permeability in patients with Crohn’s disease and their relatives. A possible etiologic factor. Ann Intern Med. 1986;105(6):883-5. doi: 10.7326/0003-4819-105-6-883.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Дурлештер В.М., Корочанская Н.В., Вершинина Г.А. Современные представления об этиологии язвенного колита. Научный вестник Здравоохранения Кубани. 2014;32(2):73-83. eLIBRARY ID: 21969185</mixed-citation><mixed-citation xml:lang="en">Дурлештер В.М., Корочанская Н.В., Вершинина Г.А. Современные представления об этиологии язвенного колита. Научный вестник Здравоохранения Кубани. 2014;32(2):73-83. eLIBRARY ID: 21969185</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Bernstein CN, Shanahan F. Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases. Gut. 2008;57(9):1185-91. doi: 10.1136/gut.2007.122143</mixed-citation><mixed-citation xml:lang="en">Bernstein CN, Shanahan F. Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases. Gut. 2008;57(9):1185-91. doi: 10.1136/gut.2007.122143</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
