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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><issn pub-type="epub">3033-8344</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2022-3-1-20-25</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-215</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Гепаторенальный синдром: критерии и проблемы диагностики (часть II)</article-title><trans-title-group xml:lang="en"><trans-title>Hepatorenal syndrome: criteria and problems of diagnosis (part II)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5754-4418</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крутиков</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krutikov</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крутиков Евгений Сергеевич – доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренней медицины.</p><p>Симферополь.</p></bio><bio xml:lang="en"><p>Evgeniy S. Krutikov - Dr. Sci. (Med.), Professor, head Department of Propedeutics of Internal Medicine, S.I. Georgievsky Medical Academy of Vernadsky Crimean Federal University.</p><p>Simferopol.</p></bio><email xlink:type="simple">nephrostar@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5100-1535</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вострикова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vostrikova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вострикова Александра Николаевна - студент кафедры внутренней медицины №1.</p><p>Симферополь.</p></bio><bio xml:lang="en"><p>Aleksandra N. Vostrikova - student, Chair of Internal Medicine No. 1, S.I. Georgievsky Medical Academy of Vernadsky Crimean Federal University.</p><p>Simferopol.</p></bio><email xlink:type="simple">ip4ne@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6200-8524</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крутикова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krutikova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Крутикова Марина Сергеевна – кандидат медицинских наук, доцент кафедры внутренней медицины.</p><p>Симферополь.</p></bio><bio xml:lang="en"><p>Marina S. Krutikova - Cand. Sci. (Med.), Associate Professor, Chair of Internal Medicine No. 1 S.I. Georgievsky Medical Academy of Vernadsky Crimean Federal University.</p><p>Simferopol.</p></bio><email xlink:type="simple">marina_ua_22@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Медицинская академия имени С.И. Георгиевского ФГАОУ ВО «Крымский федеральный университет им. В.И. Вернадского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S.I. Georgievsky Medical Academy of Vernadsky Crimean Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>16</day><month>03</month><year>2022</year></pub-date><volume>3</volume><issue>1</issue><fpage>20</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Крутиков Е.С., Вострикова А.Н., Крутикова М.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Крутиков Е.С., Вострикова А.Н., Крутикова М.С.</copyright-holder><copyright-holder xml:lang="en">Krutikov E.S., Vostrikova A.N., Krutikova M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/215">https://www.therapeutic-j.ru/jour/article/view/215</self-uri><abstract><p>Гепаторенальный синдром — развитие почечной недостаточности у больных циррозом печени характеризуется снижением почечного кровотока и скорости клубочковой фильтрации. Гепаторенальный синдром диагностируется, когда функция почек снижена, но отсутствуют признаки хронического заболевания почек. В отличие от других причин повреждения почек гепаторенальный синдром возникает в результате функциональных изменений в почечной циркуляции и потенциально обратим. Проведен анализ обзоров литературы, клинических исследований, экспериментальных исследований, клинических рекомендаций из баз данных PubMed / MedLine и eLIBRARY, по семи ключевым словам, соответствующим теме обзора.</p></abstract><trans-abstract xml:lang="en"><p>Hepatorenal syndrome, the extreme manifestation of renal impairment in patients with cirrhosis, is characterized by reduction in renal blood flow and glomerular filtration rate. Hepatorenal syndrome is diagnosed when kidney function is reduced but evidence of intrinsic kidney disease is absent. Unlike other causes of kidney injury, hepatorenal syndrome results from functional changes in the renal circulation and is potentially reversible. An analysis of literature reviews, clinical studies, experimental research, clinical recommendations from PubMed / Medline and ELIBRARY databases was carried out for 7 keywords according to the review topic.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>цирроз печени</kwd><kwd>гепаторенальный синдром</kwd><kwd>диагностика</kwd><kwd>обзор литературы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver cirrhosis</kwd><kwd>hepatorenal syndrome</kwd><kwd>diagnosis</kwd><kwd>treatment</kwd><kwd>literature review</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Scarpellini E., Luigiano C., Svegliati-Baroni G., Dumitrascu D., Larussa T., Santori V., et al. Liver Cirrhosis Complications M anagement at the Emergency Department. Rev Recent. Clin Trials. 2020;15(4):331-338. DOI: 10.2174/1574887115666200603160816</mixed-citation><mixed-citation xml:lang="en">Scarpellini E., Luigiano C., Svegliati-Baroni G., Dumitrascu D., Larussa T., Santori V., et al. Liver Cirrhosis Complications M anagement at the Emergency Department. Rev Recent. Clin Trials. 2020;15(4):331-338. DOI: 10.2174/1574887115666200603160816</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406-460. DOI: 10.1016/j.jhep.2018.03.024</mixed-citation><mixed-citation xml:lang="en">EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406-460. DOI: 10.1016/j.jhep.2018.03.024</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Angeli P., Garcia-Tsao G., Nadim M.K., Parikh C.R. News in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document. J Hepatol. 2019;71(4):811-822. DOI: 10.1016/j.jhep.2019.07.002</mixed-citation><mixed-citation xml:lang="en">Angeli P., Garcia-Tsao G., Nadim M.K., Parikh C.R. News in pathophysiology, definition and classification of hepatorenal syndrome: A step beyond the International Club of Ascites (ICA) consensus document. J Hepatol. 2019;71(4):811-822. DOI: 10.1016/j.jhep.2019.07.002</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Simonetto D. A., Gines P., Kamath P.S. Hepatorenal syndrome: pathophysiology, diagnosis, and management. BMJ. 2020;370:m2687. DOI: 10.1136/bmj.m2687</mixed-citation><mixed-citation xml:lang="en">Simonetto D. A., Gines P., Kamath P.S. Hepatorenal syndrome: pathophysiology, diagnosis, and management. BMJ. 2020;370:m2687. DOI: 10.1136/bmj.m2687</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Alessandria C., Ozdogan O., Guevara M., RestucciaT., Jimenez W., Arroyo V., et al. MELD score and clinical type predict prognosis in hepatorenal syndrome: Relevance to liver transplantation. Hepatology. 2005;41:1282-1289. DOI: 10.1002/hep.20687.</mixed-citation><mixed-citation xml:lang="en">Alessandria C., Ozdogan O., Guevara M., RestucciaT., Jimenez W., Arroyo V., et al. MELD score and clinical type predict prognosis in hepatorenal syndrome: Relevance to liver transplantation. Hepatology. 2005;41:1282-1289. DOI: 10.1002/hep.20687.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bucsics T., Krones E. Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome. Gastroenterol Rep (Oxf). 2017;5(2):127-137. DOI: 10.1093/gastro/gox009</mixed-citation><mixed-citation xml:lang="en">Bucsics T., Krones E. Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome. Gastroenterol Rep (Oxf). 2017;5(2):127-137. DOI: 10.1093/gastro/gox009</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Tujios S.R., Hynan L.S., Vazquez M.A., Larson A.M., Seremba E., Sanders C.M., et al. Acute Liver Failure Study Group. Risk factors and outcomes of acute kidney injury in patients with acute liver failure. Clin Gastroenterol Hepatol. 2015;13:352-359. DOI: 10.1016/j.cgh.2014.07.011.</mixed-citation><mixed-citation xml:lang="en">Tujios S.R., Hynan L.S., Vazquez M.A., Larson A.M., Seremba E., Sanders C.M., et al. Acute Liver Failure Study Group. Risk factors and outcomes of acute kidney injury in patients with acute liver failure. Clin Gastroenterol Hepatol. 2015;13:352-359. DOI: 10.1016/j.cgh.2014.07.011.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mindikoglu A. L. New Developments in hepatorenal syndrome. Clin Gastroenterol. Hepatol. 2018; 16(2): 162-177. DOI: 10.1016/j.cgh.2017.05.041</mixed-citation><mixed-citation xml:lang="en">Mindikoglu A. L. New Developments in hepatorenal syndrome. Clin Gastroenterol. Hepatol. 2018; 16(2): 162-177. DOI: 10.1016/j.cgh.2017.05.041</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Trawa^ J.M., Paradis V., Rautou P.E., Francoz C., Escolano S., Sal^e M., et al. The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study. Liver Int. 2010;30:725-732. DOI: 10.1111/j.1478-3231.2009.02182.x</mixed-citation><mixed-citation xml:lang="en">Trawa^ J.M., Paradis V., Rautou P.E., Francoz C., Escolano S., Sal^e M., et al. The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study. Liver Int. 2010;30:725-732. DOI: 10.1111/j.1478-3231.2009.02182.x</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Sherman DS, Fish DN, Teitelbaum I. Assessing renal function in cirrhotic patients: problems and pitfalls. Am J Kidney Dis. 2003;41:269-278. DOI: 10.1053/ajkd.2003.50035</mixed-citation><mixed-citation xml:lang="en">Sherman DS, Fish DN, Teitelbaum I. Assessing renal function in cirrhotic patients: problems and pitfalls. Am J Kidney Dis. 2003;41:269-278. DOI: 10.1053/ajkd.2003.50035</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Francoz C, Glotz D, Moreau R, Durand F. The evaluation of renal function and disease in patients with cirrhosis. J Hepatol. 2010;52:605-613. DOI: 10.1016/j.jhep.2009.11.025</mixed-citation><mixed-citation xml:lang="en">Francoz C, Glotz D, Moreau R, Durand F. The evaluation of renal function and disease in patients with cirrhosis. J Hepatol. 2010;52:605-613. DOI: 10.1016/j.jhep.2009.11.025</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cocchetto DM, Tschanz C, Bjornsson TD. Decreased rate of creatinine production in patients with hepatic disease: implications for estimation of creatinine clearance. Ther Drug Monit. 1983;5:161-168. DOI: 10.1097/00007691-19830600000002</mixed-citation><mixed-citation xml:lang="en">Cocchetto DM, Tschanz C, Bjornsson TD. Decreased rate of creatinine production in patients with hepatic disease: implications for estimation of creatinine clearance. Ther Drug Monit. 1983;5:161-168. DOI: 10.1097/00007691-19830600000002</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Francoz C., Prie D., Abdelrazek W. Moreau R., Mandot A., Belghiti J., et al. Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine: impact on the model for end-stage liver disease score. Liver Transplant. 2010;16:1169-77. DOI: 10.1002/lt.22128</mixed-citation><mixed-citation xml:lang="en">Francoz C., Prie D., Abdelrazek W. Moreau R., Mandot A., Belghiti J., et al. Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine: impact on the model for end-stage liver disease score. Liver Transplant. 2010;16:1169-77. DOI: 10.1002/lt.22128</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nadim M.K., Kellum J.A., Davenport A., Wong F., Davis C., Pannu N., et al. Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2012;16:R23. DOI: 10.1186/cc11188</mixed-citation><mixed-citation xml:lang="en">Nadim M.K., Kellum J.A., Davenport A., Wong F., Davis C., Pannu N., et al. Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2012;16:R23. DOI: 10.1186/cc11188</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Stevens L.A., Coresh J., Greene T., Levey A.S. Assessing kidney function--measured and estimated glomerular filtration rate. N Engl J Med. 2006; 354:2473-2483. DOI: 10.1056/NEJMra054415</mixed-citation><mixed-citation xml:lang="en">Stevens L.A., Coresh J., Greene T., Levey A.S. Assessing kidney function--measured and estimated glomerular filtration rate. N Engl J Med. 2006; 354:2473-2483. DOI: 10.1056/NEJMra054415</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cholongitas E, Shusang V, Marelli L., Nair D., Thomas M., Patch D., et al. Review article: renal function assessment in cirrhosis— difficulties and alternative measurements. Aliment Pharmacol Ther. 2007;26:969-978. DOI: 10.1111/j.1365-2036.2007.03443.x</mixed-citation><mixed-citation xml:lang="en">Cholongitas E, Shusang V, Marelli L., Nair D., Thomas M., Patch D., et al. Review article: renal function assessment in cirrhosis— difficulties and alternative measurements. Aliment Pharmacol Ther. 2007;26:969-978. DOI: 10.1111/j.1365-2036.2007.03443.x</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Krones E., Fickert P., Zitta S. Neunherz S.,Artinger K.,Reibnegger G. et al. The chronic kidney disease epidemiology collaboration equation combining creatinine and cystatin C accurately assesses renal function in patients with cirrhosis. BMC Nephrol. 2015;16:1-10. DOI: 10.1186/s12882-015-0188-0</mixed-citation><mixed-citation xml:lang="en">Krones E., Fickert P., Zitta S. Neunherz S.,Artinger K.,Reibnegger G. et al. The chronic kidney disease epidemiology collaboration equation combining creatinine and cystatin C accurately assesses renal function in patients with cirrhosis. BMC Nephrol. 2015;16:1-10. DOI: 10.1186/s12882-015-0188-0</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Mindikoglu A.L., Dowling T.C., Weir M.R., Seliger S.L., Christenson R.H., Magder L.S. Performance of chronic kidney disease epidemiology collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis. Hepatology. 2014;59:1532-1542. DOI: 10.1002/hep.26556</mixed-citation><mixed-citation xml:lang="en">Mindikoglu A.L., Dowling T.C., Weir M.R., Seliger S.L., Christenson R.H., Magder L.S. Performance of chronic kidney disease epidemiology collaboration creatinine-cystatin C equation for estimating kidney function in cirrhosis. Hepatology. 2014;59:1532-1542. DOI: 10.1002/hep.26556</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Arroyo V. A new method for therapeutic paracentesis: The automated low flow pump system. Comments in the context of the history of paracentesis. J Hepathology. 2013;58(5):850-852. DOI: 10.1016/j.jhep.2013.01.037</mixed-citation><mixed-citation xml:lang="en">Arroyo V. A new method for therapeutic paracentesis: The automated low flow pump system. Comments in the context of the history of paracentesis. J Hepathology. 2013;58(5):850-852. DOI: 10.1016/j.jhep.2013.01.037</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Stevens L.A., Schmid C.H., Greene T. Li L., Beck G.J., Joffe M.M., et al. Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int. 2009;75:652-60. DOI: 10.1038/ki.2008.638</mixed-citation><mixed-citation xml:lang="en">Stevens L.A., Schmid C.H., Greene T. Li L., Beck G.J., Joffe M.M., et al. Factors other than glomerular filtration rate affect serum cystatin C levels. Kidney Int. 2009;75:652-60. DOI: 10.1038/ki.2008.638</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Hazmi SF., Gad H.G.M., Alamoudi A.A., Eldakhakhny B.M., Binmahfooz S.K., Alhozali A.M. Evaluation of early biomarkers of renal dysfunction in diabetic patients. Saudi Med J. 2020;41(7):690-697. DOI: 10.15537/smj.2020.7.25168.</mixed-citation><mixed-citation xml:lang="en">Al-Hazmi SF., Gad H.G.M., Alamoudi A.A., Eldakhakhny B.M., Binmahfooz S.K., Alhozali A.M. Evaluation of early biomarkers of renal dysfunction in diabetic patients. Saudi Med J. 2020;41(7):690-697. DOI: 10.15537/smj.2020.7.25168.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Rao X., Wan M., Qiu C., Jiang C. Role of cystatin C in renal damage and the optimum cut-off point of renal damage among patients with type 2 diabetes mellitus. Experimental and therapeutic medicine. 2014; 8(3): 887-892. DOI: 10.3892/etm.2014.1815</mixed-citation><mixed-citation xml:lang="en">Rao X., Wan M., Qiu C., Jiang C. Role of cystatin C in renal damage and the optimum cut-off point of renal damage among patients with type 2 diabetes mellitus. Experimental and therapeutic medicine. 2014; 8(3): 887-892. DOI: 10.3892/etm.2014.1815</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Singal Russ K.B., Stevens T.M., Singal A.K. Acute Kidney Injury in Patients with Cirrhosis. J Clin Transl Hepatol. 2015;3(3):195-04. DOI: 10.14218/JCTH.2015.00015</mixed-citation><mixed-citation xml:lang="en">Singal Russ K.B., Stevens T.M., Singal A.K. Acute Kidney Injury in Patients with Cirrhosis. J Clin Transl Hepatol. 2015;3(3):195-04. DOI: 10.14218/JCTH.2015.00015</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Martm-LlafuM, Guevara M, Torre A, Fagundes C, Restuccia T, Gilabert R, et al. Prognostic importance of the cause of renal failure in patients with cirrhosis. Gastroenterology. 2011;140(2):488. DOI: 10.1053/j.gastro.2010.07.043</mixed-citation><mixed-citation xml:lang="en">Martm-LlafuM, Guevara M, Torre A, Fagundes C, Restuccia T, Gilabert R, et al. Prognostic importance of the cause of renal failure in patients with cirrhosis. Gastroenterology. 2011;140(2):488. DOI: 10.1053/j.gastro.2010.07.043</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mandorfer M., Bota S., Schwabl P., Bucsics T., Pfisterer N., Kruzik M., et al. Nonselective в blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis. Gastroenterology. 2014;146:1680-90.el. DOI: 10.1053/j.gastro.2014.03.005</mixed-citation><mixed-citation xml:lang="en">Mandorfer M., Bota S., Schwabl P., Bucsics T., Pfisterer N., Kruzik M., et al. Nonselective в blockers increase risk for hepatorenal syndrome and death in patients with cirrhosis and spontaneous bacterial peritonitis. Gastroenterology. 2014;146:1680-90.el. DOI: 10.1053/j.gastro.2014.03.005</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Boyer T.D., Sanyal A.J., Wong F., Frederick R.T., Lake J.R., O'Leary J.G., et al. Terlipressin plus albumin is more effective than albumin alone in improving renal function in patients with cirrhosis and hepatorenal syndrome type 1. Gastroenterology. 2016;150:1579-1589. DOI: 10.1053/j.gastro.2016.02.026</mixed-citation><mixed-citation xml:lang="en">Boyer T.D., Sanyal A.J., Wong F., Frederick R.T., Lake J.R., O'Leary J.G., et al. Terlipressin plus albumin is more effective than albumin alone in improving renal function in patients with cirrhosis and hepatorenal syndrome type 1. Gastroenterology. 2016;150:1579-1589. DOI: 10.1053/j.gastro.2016.02.026</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Cavallin M., Kamath P.S., Merli M., Fasolato S., Toniutto P., Salerno F., et al. Terlipressin plus albumin vs. midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial. Hepatology. 2015;62:567-574. DOI: 10.1002/hep.27709</mixed-citation><mixed-citation xml:lang="en">Cavallin M., Kamath P.S., Merli M., Fasolato S., Toniutto P., Salerno F., et al. Terlipressin plus albumin vs. midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial. Hepatology. 2015;62:567-574. DOI: 10.1002/hep.27709</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Cavallin M., Piano S., Romano A., Fasolato S., Frigo A.C., Benetti G., et al. Terlipressin given by continuous intravenous infusion vs. intravenous boluses in the treatment of hepatorenal syndrome: A randomized controlled study. Hepatology. 2016;63:983-992. DOI: 10.1002/hep.28396</mixed-citation><mixed-citation xml:lang="en">Cavallin M., Piano S., Romano A., Fasolato S., Frigo A.C., Benetti G., et al. Terlipressin given by continuous intravenous infusion vs. intravenous boluses in the treatment of hepatorenal syndrome: A randomized controlled study. Hepatology. 2016;63:983-992. DOI: 10.1002/hep.28396</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Piano S., Schmidt H.H., Ariza X., Amoros A., Romano A., Sola E., et al. Impact of Acute-on-Chronic Liver Failure on response to treatment with terlipressin and albumin in patients with type 1 hepatorenal syndrome. Digestive and Liver Disease. 2017;49(1): e54. DOI: 10.1016/j.dld.2017.01.108</mixed-citation><mixed-citation xml:lang="en">Piano S., Schmidt H.H., Ariza X., Amoros A., Romano A., Sola E., et al. Impact of Acute-on-Chronic Liver Failure on response to treatment with terlipressin and albumin in patients with type 1 hepatorenal syndrome. Digestive and Liver Disease. 2017;49(1): e54. DOI: 10.1016/j.dld.2017.01.108</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Глумчер Ф.С. Возможности применения альбумина в терапии критических состояний: современное состояние проблемы. Медицина неотложных состояний. 2014;2(57):65-73.</mixed-citation><mixed-citation xml:lang="en">Глумчер Ф.С. Возможности применения альбумина в терапии критических состояний: современное состояние проблемы. Медицина неотложных состояний. 2014;2(57):65-73.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов А.В., Румянцев А.Ш.* от имени рабочей группы. Острое повреждение почек. Часть I. Нефрология. 2020;24(1):67- 95. DOI: 10.36485/1561-6274-2020-24-1-67-95</mixed-citation><mixed-citation xml:lang="en">Смирнов А.В., Румянцев А.Ш.* от имени рабочей группы. Острое повреждение почек. Часть I. Нефрология. 2020;24(1):67- 95. DOI: 10.36485/1561-6274-2020-24-1-67-95</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Angeli P., Gines P., Wong F., Bernardi M., Boyer T.D., Gerbes A., et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. J Hepatol. 2015;62:968-974. DOI: 10.1016/j.jhep.2014.12.029</mixed-citation><mixed-citation xml:lang="en">Angeli P., Gines P., Wong F., Bernardi M., Boyer T.D., Gerbes A., et al. Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites. J Hepatol. 2015;62:968-974. DOI: 10.1016/j.jhep.2014.12.029</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Nadim M.K., Durand F., Kellum J.A. Levitsky J., O'Leary J.G., Karvellas C.J., et al. Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. J Hepatol. 2016; 64:717-735. DOI: 10.1016/j.jhep.2015.10.019</mixed-citation><mixed-citation xml:lang="en">Nadim M.K., Durand F., Kellum J.A. Levitsky J., O'Leary J.G., Karvellas C.J., et al. Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. J Hepatol. 2016; 64:717-735. DOI: 10.1016/j.jhep.2015.10.019</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">O'Leary J.G., Levitsky J., Wong F., Nadim M. K., Charlton M., Kim W. R. Protecting the kidney in liver transplant candidates Practice Based Recommendations from the American Society of Transplantation Liver and Intestine Community of Practice. Am J Transplant. 2016;16(9):2516-2531. DOI: 10.1111/ajt.13790</mixed-citation><mixed-citation xml:lang="en">O'Leary J.G., Levitsky J., Wong F., Nadim M. K., Charlton M., Kim W. R. Protecting the kidney in liver transplant candidates Practice Based Recommendations from the American Society of Transplantation Liver and Intestine Community of Practice. Am J Transplant. 2016;16(9):2516-2531. DOI: 10.1111/ajt.13790</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">35. Mindikoglu A.L., Dowling T.C., Wong-You-Cheong J.J., Christenson R.H., Magder L. S., Hutson W. R., et al. A pilot study to evaluate renal hemodynamics in cirrhosis by simultaneous glomerular filtration rate, renal plasma flow, renal resistive indices and biomarkers measurements. Am J Nephrol. 2014; 39:543-552. DOI: 10.1159/000363584</mixed-citation><mixed-citation xml:lang="en">Mindikoglu A.L., Dowling T.C., Wong-You-Cheong J.J., Christenson R.H., Magder L. S., Hutson W. R., et al. A pilot study to evaluate renal hemodynamics in cirrhosis by simultaneous glomerular filtration rate, renal plasma flow, renal resistive indices and biomarkers measurements. Am J Nephrol. 2014; 39:543-552. DOI: 10.1159/000363584</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Rivolta R., Maggi A., Cazzaniga M., Castagnone D.,Panzeri A., Solenghi D., et al. Reduction of renal cortical blood flow assessed by Doppler in cirrhotic patients with refractory ascites. Hepatology. 1998; 28:1235-1240. DOI: 10.1002/hep.510280510</mixed-citation><mixed-citation xml:lang="en">Rivolta R., Maggi A., Cazzaniga M., Castagnone D.,Panzeri A., Solenghi D., et al. Reduction of renal cortical blood flow assessed by Doppler in cirrhotic patients with refractory ascites. Hepatology. 1998; 28:1235-1240. DOI: 10.1002/hep.510280510</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Mindikoglu A.L., Weir M.R. Current concepts in the diagnosis and classification of renal dysfunction in cirrhosis. Am J Nephrol. 2013; 38:345-354. DOI: 10.1159/000355540</mixed-citation><mixed-citation xml:lang="en">Mindikoglu A.L., Weir M.R. Current concepts in the diagnosis and classification of renal dysfunction in cirrhosis. Am J Nephrol. 2013; 38:345-354. DOI: 10.1159/000355540</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Fagundes C., Pepin M.N., Guevara M., Barreto R., Casals G., Sola E., et al. Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis. J Hepatol. 2012; 57:267-273. DOI: 10.1016/j.jhep.2012.03.015</mixed-citation><mixed-citation xml:lang="en">Fagundes C., Pepin M.N., Guevara M., Barreto R., Casals G., Sola E., et al. Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis. J Hepatol. 2012; 57:267-273. DOI: 10.1016/j.jhep.2012.03.015</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Belcher J.M., Sanyal A.J., Peixoto A.J., Perazella M.A., Lim J., Thiessen-Philbrook H., et al. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014; 60:622-632. DOI: 10.1002/hep.26980</mixed-citation><mixed-citation xml:lang="en">Belcher J.M., Sanyal A.J., Peixoto A.J., Perazella M.A., Lim J., Thiessen-Philbrook H., et al. Kidney biomarkers and differential diagnosis of patients with cirrhosis and acute kidney injury. Hepatology. 2014; 60:622-632. DOI: 10.1002/hep.26980</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Лихота О.С., Цикуниб А.Д. Особенности метаболизма и маркеры биохимических нарушений в печени при гепатитах. Наука: комплексные проблемы. - 2017;1(9):4-11.</mixed-citation><mixed-citation xml:lang="en">Лихота О.С., Цикуниб А.Д. Особенности метаболизма и маркеры биохимических нарушений в печени при гепатитах. Наука: комплексные проблемы. - 2017;1(9):4-11.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">41. Саварина В.А., Мицура В.М., Скуратов А.Г., Мартемьянова Л.А. Проблемы диагностики гепаторенального синдрома в практике клинициста и патологоанатома. Проблемы Здоровья и Экологии. 2020;65(3):49-55.</mixed-citation><mixed-citation xml:lang="en">Саварина В.А., Мицура В.М., Скуратов А.Г., Мартемьянова Л.А. Проблемы диагностики гепаторенального синдрома в практике клинициста и патологоанатома. Проблемы Здоровья и Экологии. 2020;65(3):49-55.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Сливка Н.А., Вирстюк Н.Г., Давыденко И.С., Мартынюк Г.А., Бевз Т.И., Гайдуков В.А. Гистологические изменения почек при гепаторенальном синдроме на фоне алкогольного цирроза печени. Клиническая и экспериментальная патология. 2018;4(66):71-75. DOI: 10.24061/1727-4338.XVII.4.66.2018.191</mixed-citation><mixed-citation xml:lang="en">Сливка Н.А., Вирстюк Н.Г., Давыденко И.С., Мартынюк Г.А., Бевз Т.И., Гайдуков В.А. Гистологические изменения почек при гепаторенальном синдроме на фоне алкогольного цирроза печени. Клиническая и экспериментальная патология. 2018;4(66):71-75. DOI: 10.24061/1727-4338.XVII.4.66.2018.191</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Вирстюк Н.Г., Сливка Н.А. Диагностическая ценность допплерографического исследования при гепаторенальном синдроме. Гастроэнтерология. 2017;1(51):8-15. DOI: 10.22141/2308-2097.51.1.2017.97866</mixed-citation><mixed-citation xml:lang="en">Вирстюк Н.Г., Сливка Н.А. Диагностическая ценность допплерографического исследования при гепаторенальном синдроме. Гастроэнтерология. 2017;1(51):8-15. DOI: 10.22141/2308-2097.51.1.2017.97866</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
