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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2022-3-3-7-16</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-257</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Реверсия и ремиссия — перспективные цели для больных сахарным диабетом 2 типа</article-title><trans-title-group xml:lang="en"><trans-title>Reversion and remission are promising targets for patients with type 2 diabetes mellitus</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1510-9204</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Канорский</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanorskii</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Канорский Сергей Григорьевич, доктор медицинских наук, проф., заведующий кафедрой терапии №2 факультета повышения квалификации и профессиональной переподготовки</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Sergey G. Kanorskii, Dr. Sci. (Med.), Prof., Head of the Department of Therapy №2, Faculty of Advanced Training and Professional Retraining</p><p>Krasnodar</p></bio><email xlink:type="simple">kanorskysg@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Kuban State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>01</day><month>09</month><year>2022</year></pub-date><volume>3</volume><issue>3</issue><fpage>7</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Канорский С.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Канорский С.Г.</copyright-holder><copyright-holder xml:lang="en">Kanorskii S.G.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/257">https://www.therapeutic-j.ru/jour/article/view/257</self-uri><abstract><p>Снижение массы тела и изменение образа жизни способны привести к обратному развитию патофизиологических процессов, лежащих в основе сахарного диабета 2 типа, в том числе к достижению ремиссии болезни. Проведены поиск и анализ 9109 литературных источников из баз данных Scopus, Web of Science, PubMed/MedLine, The CochraneLibrary по ключевым словам «diabetes remission», «diabetes reversal», «bariatric surgery», «very low-calorie diet», «low carbohydrate diet». В обзоре представлены и критически оценены современные возможности достижения ремиссии сахарного диабета 2 типа с помощью бариатрической хирургии, медикаментозных препаратов, очень низкокалорийной и низкоуглеводной диет, физических упражнений.</p></abstract><trans-abstract xml:lang="en"><p>Weight loss and lifestyle changes can reverse the pathophysiological processes underlying type 2 diabetes, including achieving remission of the disease. A search and analysis of 9109 literature sources from the Scopus, Web of Science, PubMed/ MedLine, The CochraneLibrary databases was carried out for the keywords «diabetes remission», «diabetes reversal», «bariatric surgery», «very low-calorie diet», «low carbohydrate diet». The review presents and critically evaluates the current possibilities of achieving remission of type 2 diabetes mellitus with the help of bariatric surgery, medications, very low-calorie and lowcarbohydrate diets, and exercise.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>ремиссия</kwd><kwd>диета</kwd><kwd>медикаментозное лечение</kwd><kwd>бариатрическая хирургия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>review</kwd><kwd>type 2 diabetes</kwd><kwd>remission</kwd><kwd>diet</kwd><kwd>drug treatment</kwd><kwd>bariatric surgery</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Aras M, Tchang BG, Pape J. Obesity and Diabetes. Nurs Clin North Am. 2021;56(4):527-541. DOI: 10.1016/j.cnur.2021.07.008.</mixed-citation><mixed-citation xml:lang="en">Aras M, Tchang BG, Pape J. Obesity and Diabetes. 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