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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2022-3-4-77-83</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-321</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Взаимосвязь суммарной экспрессии трансформирующего фактора роста β1, моноцитарного хемоаттрактного протеина-1, сосудистого эндотелиального фактора роста-А в почечной ткани с клинико-морфологическими проявлениями при гломерулонефритах</article-title><trans-title-group xml:lang="en"><trans-title>The relationship of the total expression of transforming growth factor β1, monocytic chemoattractive protein-1, vascular endothelial growth factor-A in renal tissue with clinical and morphological manifestations in glomerulonephritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5329-7050</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батюшин</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Batiushin</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Батюшин Михаил Михайлович, д.м.н., профессор, профессор кафедры внутренних болезней №2</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Michael M. Batiushin, Dr. Sci. (Med.), Professor, professor of Internal Medicine Department №2</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">batjushin-m@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухтарова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhtarova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухтарова Айтан Валик кызы, врач-терапевт поликлиники №1</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Aitan Valik kyzy Mukhtarova, General practitioner of Polyclinic No. 1</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">ayka.mukhtarova@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синельник</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinelnik</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Синельник Елена Александровна, заведующая патологоанатомическим отделением</p><p>Ростов-на-Дону</p></bio><bio xml:lang="en"><p>Elena A. Sinelnik, Head of the pathology department of Regional Clinical Hospital No. 2</p><p>Rostov-on-Don</p></bio><email xlink:type="simple">ob2p@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Rostov State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Железнодорожная поликлиника №1 клинической больницы ОАО РЖД<country>Россия</country></aff><aff xml:lang="en">Railway Polyclinic No. 1 of the Clinical Hospital of the Russian Railways Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ГБУ «Областная клиническая больница № 2»<country>Россия</country></aff><aff xml:lang="en">Regional Clinical Hospital No. 2<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>31</day><month>12</month><year>2022</year></pub-date><volume>3</volume><issue>4</issue><fpage>77</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Батюшин М.М., Мухтарова А.В., Синельник Е.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Батюшин М.М., Мухтарова А.В., Синельник Е.А.</copyright-holder><copyright-holder xml:lang="en">Batiushin M.M., Mukhtarova A.V., Sinelnik E.A.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/321">https://www.therapeutic-j.ru/jour/article/view/321</self-uri><abstract><p>Цель: изучение влияния выраженности суммарной экспрессии сосудистого эндотелиального фактора роста А (VEGF А), тканевого фактора роста β1 (TGF-β1) и моноцитарного хемоаттрактантного фактора 1 (MCP-1) на течение гломерулонефритов.Материалы и методы: исследование проспективное (12 мес.) открытое сравнительное клинико-морфологическое с включением 75 больных в возрасте от 18 до 75 лет (лиц мужского пола — 52, женского пола — 23) с гломерулонефритом в стадии обострения. Всем пациентам исходно проводилось обследование, включая оценку клинико-лабораторных и инструментальных показателей, в том числе пункционная нефробиопсия. В дополнение к стандарту срезы биоптатов окрашивались маркированными антителами к VEGF А, TGF-β1 и MCP-1 для оценки их экспрессии в ткани почек. Спустя 12 месяцев оценивалось развитие ремиссии гломерулонефрита, параметры общего анализа мочи, креатинина, мочевины, мочевой кислоты крови, расчет СКФ.Результаты: установлено, что выраженность суммарной экспрессии MCP-1+VEGF-А+TGFβ1 наблюдается в большей мере при гематурических формах гломерулонефрита, протекающих без изменений уровня альбумина крови. Это же следует из результатов, демонстрирующих связь суммарной экспрессии MCP-1+VEGF-А+TGFβ1 с морфологическими проявлениями, в большей мере свойственными нефритическим формам гломерулонефрита (депозиты IgA, мезангиальная гиперклеточность). Повышение экспрессии изученных факторов доказало свое влияние на развитие фиброза и утолщение стенок почечных сосудов, фиброз клубочков и интерстиция, отражающих в целом комплекс репаративного ремоделирования почечной ткани в условиях воспалительного процесса. Выявлено влияние суммарной экспрессии MCP-1+VEGF-А+TGFβ1 на дальнейшее течение гломерулонефрита, сопровождающееся прогрессированием болезни в виде снижения СКФ спустя 12 мес. наблюдения за больными.Выводы: повышение суммарной экспрессии MCP-1+VEGF-А+TGFβ1 при гематурических формах гломерулонефрита свидетельствует о роли данных факторов в развитии воспалительного процесса в большей степени при этих формах болезни. Установлено, что повышение выраженности суммарной экспрессии MCP-1+VEGF-А+TGFβ1 ассоциируется с проявлениями почечного ремоделирования при гломерулонефрите. Показано, что повышение выраженности суммарной экспрессии MCP-1+VEGF-А+TGFβ1 сопровождается повышением вероятности быстрого снижения почечной функции при гломерулонефрите при двенадцатимесячном наблюдении.</p></abstract><trans-abstract xml:lang="en"><p>Objective: to study the effect of the total expression of vascular endothelial growth factor A (VEGF A), tissue growth factor β1 (TGF-β1) and monocytic chemoattractant factor 1 (MCP-1) on the course of glomerulonephritis.Material and methods: the study was a prospective (12-month) open comparative clinical and morphological study with the inclusion of 75 patients aged 18 to 75 years (males - 52, females - 23) with glomerulonephritis in the acute stage. All patients were initially examined, including assessment of clinical, laboratory and instrumental parameters, including puncture nephrobiopsy. In addition to the standard, sections of biopsies were stained with labeled antibodies to VEGF A, TGF-β1 and MCP-1 to assess their expression in kidney tissue. After 12 months, the development of remission of glomerulonephritis, parameters of the general analysis of urine, creatinine, urea, uric acid of blood, calculation of GFR were evaluated.Results: it was found that the severity of the total expression of MCP-1+VEGF-A+TGFß1 is observed to a greater extent in hematuric forms of glomerulonephritis, occurring without changes in the level of blood albumin. The same follows from the results demonstrating the relationship of the total expression of MCP-1+VEGF-A+TGFß1 with morphological manifestations more characteristic of nephritic forms of glomerulonephritis (IgA deposits, mesangial hypercellularity). The increased expression of the studied factors has shown its influence on the development of fibrosis and thickening of the walls of renal vessels, glomerular fibrosis and interstitium, reflecting the whole complex of reparative remodeling of renal tissue in the inflammatory process. The effect of the total expression of MCP-1+VEGF-A+TGFß1 on the further course of glomerulonephritis, accompanied by the progression of the disease in the form of a decrease in GFR after 12 months of observation of patients, was revealed.Conclusions: an increase in the total expression of MCP-1+VEGF-A+TGFß1 in hematuric forms of glomerulonephritis indicates the role of these factors in the development of the inflammatory process to a greater extent in these forms of the disease. It was found that an increase in the severity of the total expression of MCP-1+VEGF-A+TGFß1 is associated with manifestations of renal remodeling in glomerulonephritis. It has been shown that an increase in the severity of the total expression of MCP-1+VEGF-A+TGFß1 is accompanied by an increase in the likelihood of a rapid decrease in renal function in glomerulonephritis at 12-month follow-up.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>моноцитарный хемоаттрактный протеин 1</kwd><kwd>сосудистый эндотелиальный фактор роста А</kwd><kwd>тканевой фактор роста β1</kwd><kwd>гломерулонефрит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>monocytic chemoattractive protein 1</kwd><kwd>vascular endothelial growth factor A</kwd><kwd>tissue growth factor β1</kwd><kwd>glomerulonephritis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бобкова И.Н., Чеботарева Н.В., Козловская Л.В., Непринцева Н.В. Система самозащиты почки: современный взгляд на механизмы, определяющие течение и исход гломерулонефрита (обзор литературы). 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