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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2022-3-4-92-99</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-323</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Вторичная артериальная гипертония и эндогенный гиперкортицизм в общей врачебной практике</article-title><trans-title-group xml:lang="en"><trans-title>Secondary arterial hypertension and endogenous hypercortisolism in general medical practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4145-5602</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрик</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrik</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрик Галина Георгиевна, д.м.н., доцент, профессор кафедры терапии 1 ФПК и ППС; врач-эндокринолог</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Galina G. Petrik, Dr. Sci. (Med.), Professor Chair of Therapy N1; endocrinologist Endocrinology Departmen</p><p>Krasnodar</p></bio><email xlink:type="simple">pgg@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8600-0199</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Космачева</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosmacheva</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Космачева Елена Дмитриевна, д.м.н., профессор, заведующий кафедрой терапии №1 ФПК и ППС; заместитель главного врача по медицинской части</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Elena D. Kosmacheva, Dr. Sci. (Med.), Professor, Head of the Department of Therapy 1; assistant to the head physician by a medical part</p><p>Krasnodar</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4823-4100</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бутаева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Butaeva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бутаева Светлана Васильевна, заведующий эндокринологическим отделением</p><p>Краснодар</p></bio><bio xml:lang="en"><p>SvetlanaV. Butaeva, Head of the Endocrinology Department</p><p>Krasnodar</p></bio><email xlink:type="simple">svetbutaeva@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5424-6677</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>V. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смирнова Вероника Леонидовна, врач-эндокринолог эндокринологического отделения</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Veronika L. Smirnova, endocrinologist Endocrinology Department</p><p>Krasnodar</p></bio><email xlink:type="simple">mirn@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2939-6307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мишина</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mishina</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мишина Анастасия Михайловна – врач-эндокринолог эндокринологического отделения</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Anastasia M. Mishina, endocrinologist Endocrinology Department</p><p>Krasnodar</p></bio><email xlink:type="simple">anastasija-mishina@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; ГБУЗ «НИИ-Краевая Клиническая больница №1 им. профессора С.В. Очаповского» Минздрава Краснодарского края<country>Россия</country></aff><aff xml:lang="en">Kuban State Medical University; Research Institute – Prof. S.V. Ochapovsky Regional Clinical Hospital № 1<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ «НИИ-Краевая Клиническая больница №1 им. профессора С.В. Очаповского» Минздрава Краснодарского края<country>Россия</country></aff><aff xml:lang="en">Research Institute – Prof. S.V. Ochapovsky Regional Clinical Hospital № 1<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>31</day><month>12</month><year>2022</year></pub-date><volume>3</volume><issue>4</issue><fpage>92</fpage><lpage>99</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петрик Г.Г., Космачева Е.Д., Бутаева С.В., Смирнова В.Л., Мишина А.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Петрик Г.Г., Космачева Е.Д., Бутаева С.В., Смирнова В.Л., Мишина А.М.</copyright-holder><copyright-holder xml:lang="en">Petrik G.G., Kosmacheva E.D., Butaeva S.V., Smirnova V.L., Mishina A.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/323">https://www.therapeutic-j.ru/jour/article/view/323</self-uri><abstract><p>Синдром артериальной гипертонии (АГ) широко распространён в клинической практике. В подавляющем большинстве случаев повышение артериального давления носит эссенциальный характер. Между тем многие клинические ситуации требуют исключения вторичной АГ вследствие ятрогений, почечной, эндокринной, сердечно-сосудистой, неврологической патологии. Особое место в структуре эндокринных АГ занимает патология, связанная с избыточной продукцией кортизола. Несмотря на неоднородность происхождения, эндогенный гиперкортицизм (ЭГ) имеет определённое сходство клинических проявлений. В статье описаны два клинических случая АГ у женщин 32-х лет с различными патогенетическими вариантами эндогенного гиперкортицизма (ЭГ). Представленные истории болезни положены в основу обсуждения особенностей клинико-лабораторных проявлений ЭГ, принципов дифференциальной диагностики и современных подходов к лечению. Целью настоящей публикации является привлечение внимания врачей различных специальностей к раннему выявлению ЭГ, своевременное устранение которого существенно улучшает качество и увеличивает продолжительность жизни больных.</p></abstract><trans-abstract xml:lang="en"><p>Arterial hypertension (AH) is a widespread syndrome in clinical practice. In most cases, the blood pressure increase is essential (primary) in nature. Meanwhile, many clinical situations require exclusion of secondary AH due medications and other substances, renal, endocrine, cardiovascular, neurological pathology. A special place in the structure of the endocrine AH is engaged in pathology caused by excessive production of cortisol. Despite its heterogeneous origin, endogenous hype rcortisolism (EH) has a certain similarity in clinical manifestations. The article describes two clinical cases of AH in 32-year-old women with different pathogenetic variants of endogenous hypercortisolism (EH). The presented medical histories are the basis for the discussion of features of the clinical and laboratory manifestations of EH, principles of the differential diagnos is and modern approaches to treatment. The aim of this publication is to draw attention of doctors of various specialties to early detection of EH, the timely elimination of which significantly improves the quality and increases the life expectancy of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>артериальное давление</kwd><kwd>синдром Кушинга</kwd><kwd>клинический случай</kwd><kwd>эндогенный гиперкортицизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>blood pressure</kwd><kwd>Cushing's syndrome</kwd><kwd>clinical case</kwd><kwd>hypercortisolism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-3104. doi: 10.1093/eurheartj/ehy339. Erratum in: Eur Heart J. 2019;40(5):475.</mixed-citation><mixed-citation xml:lang="en">Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39(33):3021-3104. doi: 10.1093/eurheartj/ehy339. Erratum in: Eur Heart J. 2019;40(5):475.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217-23. doi: 10.1016/S0140-6736(05)17741-1</mixed-citation><mixed-citation xml:lang="en">Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217-23. doi: 10.1016/S0140-6736(05)17741-1</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Steffensen C, Bak AM, Rubeck KZ, Jørgensen JO. Epidemiology of Cushing's syndrome. Neuroendocrinology. 2010;92 Suppl 1:1-5. doi: 10.1159/000314297</mixed-citation><mixed-citation xml:lang="en">Steffensen C, Bak AM, Rubeck KZ, Jørgensen JO. Epidemiology of Cushing's syndrome. Neuroendocrinology. 2010;92 Suppl 1:1-5. doi: 10.1159/000314297</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Charles L, Triscott J, Dobbs B. Secondary Hypertension: Discovering the Underlying Cause. Am Fam Physician. 2017;96(7):453-461. PMID: 29094913.</mixed-citation><mixed-citation xml:lang="en">Charles L, Triscott J, Dobbs B. Secondary Hypertension: Discovering the Underlying Cause. Am Fam Physician. 2017;96(7):453-461. PMID: 29094913.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Белая Ж.Е., Рожинская Л.Я., Вагапова Г.Р. и соавт. Клинические рекомендации Болезнь Иценко-Кушинга: Клиника, диагностика, дифференциальная диагностика, методы лечения. Москва, 2014.</mixed-citation><mixed-citation xml:lang="en">Белая Ж.Е., Рожинская Л.Я., Вагапова Г.Р. и соавт. Клинические рекомендации Болезнь Иценко-Кушинга: Клиника, диагностика, дифференциальная диагностика, методы лечения. Москва, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman LK. Cushing's syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015;173(4):M33-8. doi: 10.1530/EJE-15-0464</mixed-citation><mixed-citation xml:lang="en">Nieman LK. Cushing's syndrome: update on signs, symptoms and biochemical screening. Eur J Endocrinol. 2015;173(4):M33-8. doi: 10.1530/EJE-15-0464</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, et al. Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes Endocrinol. 2021;9(12):847-875. doi: 10.1016/S2213-8587(21)00235-7</mixed-citation><mixed-citation xml:lang="en">Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, et al. Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes Endocrinol. 2021;9(12):847-875. doi: 10.1016/S2213-8587(21)00235-7</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, et al. Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(8):2807-31. doi: 10.1210/jc.2015-1818</mixed-citation><mixed-citation xml:lang="en">Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, et al. Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2015;100(8):2807-31. doi: 10.1210/jc.2015-1818</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing's syndrome. Lancet. 2015;386(9996):913-27. doi: 10.1016/S0140-6736(14)61375-1</mixed-citation><mixed-citation xml:lang="en">Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing's syndrome. Lancet. 2015;386(9996):913-27. doi: 10.1016/S0140-6736(14)61375-1</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
