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<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2023-4-2-7-17</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-339</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Растворимый белок подавления онкогенности (sST2) в качестве возможного биомаркера у пациентов с острым коронарным синдромом</article-title><trans-title-group xml:lang="en"><trans-title>Soluble tumorigenicity suppression protein (sST2) as a possible biomarker in patients with acute coronary syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1468-5074</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фетисова</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Fetisova</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фетисова Валерия Игоревна - аспирант кафедры терапии №1 ФПК и ППС ФГБОУ ВО «КубГМУ» Минздрава России; врач-кардиолог кардиологического отделения №2 для больных с инфарктом миокарда ГБУЗ «НИИ – ККБ №1 им. проф. С.В. Очаповского».</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Valeria I. Fetisova - postgraduate  student  of the Department of Therapy No. 1 of the Kuban State Medical University, cardiologist of the Emergency cardiology department No. 2 of the Scientific Research Institute - Regional Clinical Hospital No.1 named after. prof. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">fetisovavi22@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5866-506X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намитоков</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Namitokov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Намитоков Алим Муратович – кандидат медицинских наук, заведующий кардиологическим отделением №2 для больных с инфарктом миокарда ГБУЗ «НИИ – ККБ №1 им. проф. С.В. Очаповского».</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Alim M. Namitokov - Cand. Sci. (Med.), Head of Emergency cardiology department No. 2 of the Scientific Research Institute - Regional Clinical Hospital No.1 named after. prof. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">namitokov.alim@gmail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9766-1811</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гилевич</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gilevich</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гилевич Ирина Валерьевна - кандидат медицинских наук, ассистент кафедры онкологии с курсом торакальной хирургии ФПК и ППС ФГБОУ ВО «КубГМУ» Минздрава России, заведующий лабораторией ГБУЗ «НИИ – ККБ №1 им. проф. С.В. Очаповского».</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Irina V. Gilevich - Cand. Sci. (Med.), Assistant of the Department of Oncology with the course of thoracic Surgery of the Kuban State Medical University, Head of the Laboratory of the Scientific Research Institute – Regional Clinical Hospital No.1 named after. prof. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">giliv@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8600-0199</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Космачева</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosmacheva</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Космачёва Елена Дмитриевна – доктор медицинских наук, профессор, заместитель главного врача по лечебной работе ГБУЗ «НИИ – ККБ №1 им. проф. С.В. Очаповского».</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Elena D. Kosmacheva - Dr. Sci. (Med.),  Professor, Scientific Research Institute – Regional Clinical Hospital No.1 named after. prof. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">kosmachova_h@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО Кубанский государственный медицинский университет Минздрава России; ГБУЗ Научно-исследовательский институт – Краевая клиническая больница №1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского края<country>Россия</country></aff><aff xml:lang="en">Kuban State Medical University; S.V. Ochapovsky Regional Clinical Hospital №1<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ Научно-исследовательский институт – Краевая клиническая больница №1 им. проф. С.В. Очаповского Министерства здравоохранения Краснодарского края<country>Россия</country></aff><aff xml:lang="en">S.V. Ochapovsky Regional Clinical Hospital №1<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>06</month><year>2023</year></pub-date><volume>4</volume><issue>2</issue><fpage>7</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фетисова В.И., Намитоков А.М., Гилевич И.В., Космачева Е.Д., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Фетисова В.И., Намитоков А.М., Гилевич И.В., Космачева Е.Д.</copyright-holder><copyright-holder xml:lang="en">Fetisova V.I., Namitokov A.M., Gilevich I.V., Kosmacheva E.D.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/339">https://www.therapeutic-j.ru/jour/article/view/339</self-uri><abstract><p>За последние десятилетия было разработано множество прогностических инструментов, однако идентификация биомаркеров, которые могут предсказать риск острой коронарной болезни и связанных с ней осложнений, особенно сердечной недостаточности,  остаётся перспективным направлением, изучение которого  обеспечит понимание патофизиологии  этого заболевания и определение новых целей для терапии. Одним из таких потенциальных биомаркеров является растворимый белок подавления онкогенности  2, который способен не только прогнозировать ремоделирование левого желудочка и неблагоприятный клинический исход среди пациентов с острым коронарным синдромом, но и дополнять другие, хорошо зарекомендовавшие себя сердечные биомаркеры, такие как натрийуретические пептиды и сердечные тропонины. В то же время, если в патогенез острой коронарной болезни вовлечён ряд отдельных, но часто сходящихся путей, то мультимаркерные подходы с различными комбинациями новых сердечных биомаркеров и их постоянная оценка, вероятно, улучшит прогнозирование сердечного риска и отдаленных исходов.</p></abstract><trans-abstract xml:lang="en"><p>Many prognostic tools have been developed over the past decades, however, the identification of biomarkers that can predict the risk of acute coronary disease and its associated complications, especially heart failure, remains a promising direction, the study of which will provide understanding of the pathophysiology of this disease and identify new targets for therapy. One such potential biomarker is soluble suppression of tumorigenicity 2, which is able not only to predict left ventricular remodeling and poor clinical outcome among patients with acute coronary syndrome, but also to complement other well-established cardiac biomarkers such as natriuretic peptides and cardiac troponins. At the same time, if a number of separate but often converging pathways are involved in the pathogenesis of acute coronary disease, then multimarker approaches with various combinations of new cardiac biomarkers and their continuous assessment are likely to improve the prediction of cardiac risk and long-term outcomes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>биомаркер</kwd><kwd>растворимый белок подавления онкогенности 2</kwd><kwd>sST2</kwd><kwd>острый коронарный синдром</kwd><kwd>ремоделирование миокарда</kwd></kwd-group><kwd-group xml:lang="en"><kwd>biomarker</kwd><kwd>soluble suppression of tumorigenicity 2</kwd><kwd>sST2</kwd><kwd>acute coronary syndrome</kwd><kwd>myocardial remodeling</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Frioes F, Louren?o P, Laszczynska O, Almeida PB, Guimaraes JT, Januzzi JL, et al. 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