therapeuticЮжно-Российский журнал терапевтической практикиSouth Russian Journal of Therapeutic Practice2712-8156РостГМУ10.21886/2712-8156-2023-4-1-106-112therapeutic-341Research ArticleКЛИНИЧЕСКИЕ СЛУЧАИCLINICAL CASESРедкая форма системного амилоидоза с поражением почек – Afib амилоидозA rare form of systemic amyloidosis with kidney damage — AFIB-amyloidosishttps://orcid.org/0000-0002-2733-4524БатюшинМ. М.BatyushinM. M.

Батюшин Михаил Михайлович, профессор, д.м.н., профессор кафедры внутренних болезней

Ростов-на-Дону

Mikhail Mikhailovich Batyushin, Professor, Dr. Sci. (Med.), Professor of the Department of Internal Diseases No. 2

Rostov-on-Don

batjushin-m@rambler.ruАблякимоваЛ. Р.AblyakimovaL. R.

Аблякимова Лера Рустемовна, врач-нефролог

Батайск

Ablyakimova Lera Rusikmovna, nephrologist

Bataysk

l.ablyalimova00@mail.ruhttps://orcid.org/0000-0002-5933-5732СарвилинаИ. В.SarvilinaI. V.

Сарвилина Ирина Владиславовна, профессор, д.м,н, директор

Ростов-на-Дону

Irina Vladislavovna Sarvilina, Professor, Dr. Sci. (Med.), Director

Rostov-on-Don

sarvilina@mail.ruФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РФРоссияRostov State Medical UniversityRussian FederationКлиническая больница «РЖД-Медицина»РоссияClinical Hospital "RZD-Medicine"Russian FederationМедицинский центр «Новомедицина»РоссияNovomedicine Medical CenterRussian Federation20232803202341106112Copyright © Батюшин М.М., Аблякимова Л.Р., Сарвилина И.В., 20232023Батюшин М.М., Аблякимова Л.Р., Сарвилина И.В.Batyushin M.M., Ablyakimova L.R., Sarvilina I.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therapeutic-j.ru/jour/article/view/341

В рамках данной публикации представлено первое в РФ описание формы AFib амилоидоза с поражением почек. Выявление редкой формы амилоидоза стало возможным после морфологического исследования почек и типирования амилоида на АА и AL-формы, а также масс-спектрометрического исследования крови и мочи пациента.

Within the framework of this publication, the first description of the AFib-form of amyloidosis with kidney damage in the Russian Federation is presented. Detection of a rare form of amyloidosis became possible after morphological examination of the kidneys and typing of amyloid into AA and AL forms, as well as mass spectrometric examination of the patient's blood and urine.

AFib амилоидозмасс-спктрометрияAFib-amyloidosismass spectrometryReferencesBenson M.D., Buxbaum J.N., Eisenberg D.S., Merlini G., Saraiva M.J.M., Sekijima Y. et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018;25(4):215-219. doi: 10.1080/13506129.2018.1549825.Benson M.D., Buxbaum J.N., Eisenberg D.S., Merlini G., Saraiva M.J.M., Sekijima Y. et al. Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018;25(4):215-219. doi: 10.1080/13506129.2018.1549825.Nie P., Chen R., Luo M., Dong C., Chen L., Liu J. et al. Clinical and Pathological Analysis of 4910 Patients Who Received Renal Biopsies at a Single Center in Northeast China. Biomed Res Int. 2019;2019:6869179. doi: 10.1155/2019/6869179.Nie P., Chen R., Luo M., Dong C., Chen L., Liu J. et al. Clinical and Pathological Analysis of 4910 Patients Who Received Renal Biopsies at a Single Center in Northeast China. Biomed Res Int. 2019;2019:6869179. doi: 10.1155/2019/6869179.Nie P., Lou Y., Wang Y., Bai X., Zhang L., Jiang S. et al. Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study. Ren. Fail. 2021;43(1):851–859. doi: 10.1080/0886022X.2021.1923527Nie P., Lou Y., Wang Y., Bai X., Zhang L., Jiang S. et al. Clinical and pathological analysis of renal biopsies of elderly patients in Northeast China: a single-center study. Ren. Fail. 2021;43(1):851–859. doi: 10.1080/0886022X.2021.1923527Li Z.Y., Wang S., Li D.Y., Liu D., Wang S.X., Yu X.J. et al. Fibrinogen A Alpha-Chain Amyloidosis in Two Chinese Patients. Front Med (Lausanne). 2022;9:869409. doi: 10.3389/fmed.2022.869409.Li Z.Y., Wang S., Li D.Y., Liu D., Wang S.X., Yu X.J. et al. Fibrinogen A Alpha-Chain Amyloidosis in Two Chinese Patients. Front Med (Lausanne). 2022;9:869409. doi: 10.3389/fmed.2022.869409.Said S.M., Sethi S., Valeri A.M., Leung N., Cornell L.D., Fidler M.E. et al. Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases. Clin J Am Soc Nephrol. 2013;8(9):1515-23. doi: 10.2215/CJN.10491012.Said S.M., Sethi S., Valeri A.M., Leung N., Cornell L.D., Fidler M.E. et al. Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases. Clin J Am Soc Nephrol. 2013;8(9):1515-23. doi: 10.2215/CJN.10491012.Benson M.D., Liepnieks J., Uemichi T., Wheeler G., Correa R. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Nat Genet. 1993;3:252–5. 10.1038/ng0393-252.Benson M.D., Liepnieks J., Uemichi T., Wheeler G., Correa R. Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Nat Genet. 1993;3:252–5. 10.1038/ng0393-252.Weisel J.W., Litvinov R.I. Mechanisms of fibrin polymerization and clinical implications. Blood. 2013;121:1712–9. 10.1182/blood-2012-09-306639.Weisel J.W., Litvinov R.I. Mechanisms of fibrin polymerization and clinical implications. Blood. 2013;121:1712–9. 10.1182/blood-2012-09-306639.Yazaki M., Yoshinaga T., Sekijima Y., Kametani F., Okumura N. Hereditary fibrinogen aalpha-chain amyloidosis in Asia: clinical and molecular characteristics. Int J Molec Sci. 2018;19.10.3390/ijms19010320.Yazaki M., Yoshinaga T., Sekijima Y., Kametani F., Okumura N. Hereditary fibrinogen aalpha-chain amyloidosis in Asia: clinical and molecular characteristics. Int J Molec Sci. 2018;19.10.3390/ijms19010320.Gillmore J.D., Lachmann H.J., Rowczenio D., Gilbertson J.A., Zeng C.H., Liu Z.H. et al.. Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosis. J Am Soc Nephrol. 2009;20:444–51. 10.1681/ASN.2008060614Gillmore J.D., Lachmann H.J., Rowczenio D., Gilbertson J.A., Zeng C.H., Liu Z.H. et al.. Diagnosis, pathogenesis, treatment, and prognosis of hereditary fibrinogen A alpha-chain amyloidosis. J Am Soc Nephrol. 2009;20:444–51. 10.1681/ASN.2008060614Ihne S., Morbach C., Sommer C., Geier A., Knop S., Störk S. Amyloidosis-the Diagnosis and Treatment of an Underdiagnosed Disease. Dtsch Arztebl Int. 2020;117(10):159-166. doi: 10.3238/arztebl.2020.0159.Ihne S., Morbach C., Sommer C., Geier A., Knop S., Störk S. Amyloidosis-the Diagnosis and Treatment of an Underdiagnosed Disease. Dtsch Arztebl Int. 2020;117(10):159-166. doi: 10.3238/arztebl.2020.0159.

The authors declare that there are no conflicts of interest present.