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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><issn pub-type="epub">3033-8344</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2020-1-2-93-101</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-38</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Диабетическая кардиомиопатия: определение, критерии диагноза, направления терапии и предупреждение сердечной недостаточности</article-title><trans-title-group xml:lang="en"><trans-title>Diabetic cardiomyopathy: definition, diagnosis criteria, treatment directions and prevention of heart failure</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7003-5186</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козиолова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Koziolova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козиолова Наталья Андреевна, доктор медицинских наук, профессор, заведующая кафедрой пропедевтики внутренних болезней №2</p><p>Пермь</p></bio><bio xml:lang="en"><p>Natalya A. Koziolova, Dr. Ci. (Med.), Prof.</p><p>Perm</p></bio><email xlink:type="simple">nakoziolova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1103-3812</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Караваев</surname><given-names>П. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Karavaev</surname><given-names>P. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Караваев Павел Георгиевич, ассистент кафедры пропедевтики внутренних болезней №2</p><p>Пермь</p></bio><bio xml:lang="en"><p>Pavel G. Karavaev</p><p>Perm</p></bio><email xlink:type="simple">pakarawaew@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8769-7335</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Веклич</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Veklich</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Веклич Андрей Станиславович, ассистент кафедры пропедевтики внутренних болезней №2</p><p>Пермь</p></bio><bio xml:lang="en"><p>Andrey S. Veklich</p><p>Perm</p></bio><email xlink:type="simple">andrei_veklich@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Пермский государственный медицинский университет имени академика Е.А. Вагнера» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Academician Ye.A. Wagner Perm State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>08</month><year>2020</year></pub-date><volume>1</volume><issue>2</issue><fpage>93</fpage><lpage>101</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козиолова Н.А., Караваев П.Г., Веклич А.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Козиолова Н.А., Караваев П.Г., Веклич А.С.</copyright-holder><copyright-holder xml:lang="en">Koziolova N.A., Karavaev P.G., Veklich A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/38">https://www.therapeutic-j.ru/jour/article/view/38</self-uri><abstract><p>В тематическом обзоре обсуждены различные точки зрения, касающиеся терминологии, диагностических критериев, трудностей оценки распространенности и стадий течения диабетической кардиомиопатии, представлены используемые в клинической практике и потенциальные инструментальные, лабораторные методы диагностики, приведены лечебные методики и стратегические направления терапии данного состояния и профилактики хронической сердечной недостаточности.</p></abstract><trans-abstract xml:lang="en"><p>The topical review discusses various points of view related to terminology, diagnostic criteria, difficulties in assessing the prevalence and stages of diabetic cardiomyopathy, presents used in clinical practice and potential instrumental and laboratory diagnostic methods, provides therapeutic methods and strategic directions for the treatment of this condition and the prevention of chronic heart failure.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>диабетическая кардиомиопатия</kwd><kwd>диагностические критерии</kwd><kwd>лечение</kwd><kwd>профилактика сердечной недостаточности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>review</kwd><kwd>diabetic cardiomyopathy</kwd><kwd>diagnostic criteria</kwd><kwd>treatment</kwd><kwd>prevention of heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Trachanas K., Sideris S., Aggeli C., Poulidakis E., Gatzoulis K., Tousoulis D., et al. Diabetic cardiomyopathy: from pathophysiology to treatment. Hellenic J Cardiol.2014;55:411– 421. PMID: 25243440</mixed-citation><mixed-citation xml:lang="en">Trachanas K., Sideris S., Aggeli C., Poulidakis E., Gatzoulis K., Tousoulis D., et al. Diabetic cardiomyopathy: from pathophysiology to treatment. Hellenic J Cardiol.2014;55:411– 421. PMID: 25243440</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lundbaek K. Diabetic angiopathy. A specific vascular disease. Lancet. 1954;263:377–379. https://doi.org/10.1016/S0140-6736(54)90924-1</mixed-citation><mixed-citation xml:lang="en">Lundbaek K. Diabetic angiopathy. A specific vascular disease. Lancet. 1954;263:377–379. https://doi.org/10.1016/S0140-6736(54)90924-1</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Rubler S., Dlugash J., Yuceoglu Y.Z., Kumral T., Branwood A.W., Grishman A., et al. New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol. 1972;30:595- 602. https://doi.org/10.1016/0002-9149(72)90595-4</mixed-citation><mixed-citation xml:lang="en">Rubler S., Dlugash J., Yuceoglu Y.Z., Kumral T., Branwood A.W., Grishman A., et al. New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol. 1972;30:595- 602. https://doi.org/10.1016/0002-9149(72)90595-4</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kannel W.B., Hjortland M., Castelli W.P. Role of diabetes in congestive heart failure; the Framingham study. Am J Cardiol. 1974;34:29–34. https://doi.org/10.1016/0002-9149(74)90089-7</mixed-citation><mixed-citation xml:lang="en">Kannel W.B., Hjortland M., Castelli W.P. Role of diabetes in congestive heart failure; the Framingham study. Am J Cardiol. 1974;34:29–34. https://doi.org/10.1016/0002-9149(74)90089-7</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Penpargkul S., Fein F., Sonnenblick E.H., Scheuer J. Depressed cardiac sarcoplasmic reticular function from diabetic rats. J Mol Cell Cardiol. 1981;13:303-9. https://doi.org/10.1016/0022-2828(81)90318-7</mixed-citation><mixed-citation xml:lang="en">Penpargkul S., Fein F., Sonnenblick E.H., Scheuer J. Depressed cardiac sarcoplasmic reticular function from diabetic rats. J Mol Cell Cardiol. 1981;13:303-9. https://doi.org/10.1016/0022-2828(81)90318-7</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Trost S.U., Belke D.D., Bluhm W.F., Meyer M., Swanson E., Dillmann W.H. Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy. Diabetes. 2002;51:1166–71. https://doi.org/10.2337/diabetes.51.4.1166</mixed-citation><mixed-citation xml:lang="en">Trost S.U., Belke D.D., Bluhm W.F., Meyer M., Swanson E., Dillmann W.H. Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy. Diabetes. 2002;51:1166–71. https://doi.org/10.2337/diabetes.51.4.1166</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenzo-Almorós A., Tuñón J., Orejas M., Cortés M., Egido J., Lorenzo Ó. Diagnostic approaches for diabetic cardiomyopathy. Cardiovasc Diabetol. 2017;16(1):28. https://doi.org/10.1186/s12933-017-0506-x</mixed-citation><mixed-citation xml:lang="en">Lorenzo-Almorós A., Tuñón J., Orejas M., Cortés M., Egido J., Lorenzo Ó. Diagnostic approaches for diabetic cardiomyopathy. Cardiovasc Diabetol. 2017;16(1):28. https://doi.org/10.1186/s12933-017-0506-x</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Marcinkiewicz A., Ostrowski S., Drzewoski J. Can the onset of heart failure be delayed by treating diabetic cardiomyopathy? Diabetol Metab Syndr. 2017;9:21. https://doi.org/10.1186/s13098-017-0219-z</mixed-citation><mixed-citation xml:lang="en">Marcinkiewicz A., Ostrowski S., Drzewoski J. Can the onset of heart failure be delayed by treating diabetic cardiomyopathy? Diabetol Metab Syndr. 2017;9:21. https://doi.org/10.1186/s13098-017-0219-z</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lee W.S., Kim J. Diabetic cardiomyopathy: where we are and where we are going. Korean J Intern Med. 2017;32(3):404- 421. https://doi.org/10.3904/kjim.2016.208.</mixed-citation><mixed-citation xml:lang="en">Lee W.S., Kim J. Diabetic cardiomyopathy: where we are and where we are going. Korean J Intern Med. 2017;32(3):404- 421. https://doi.org/10.3904/kjim.2016.208.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Dillmann W.H. Diabetic Cardiomyopathy. Circ Res. 2019;124(8):1160-1162. https://doi.org/10.1161/CIRCRESAHA.118.314665</mixed-citation><mixed-citation xml:lang="en">Dillmann W.H. Diabetic Cardiomyopathy. Circ Res. 2019;124(8):1160-1162. https://doi.org/10.1161/CIRCRESAHA.118.314665</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Jia G., Hill M.A., Sowers J.R. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ Res. 2018;122(4):624-638. https://doi.org/10.1161/CIRCRESAHA.117.311586</mixed-citation><mixed-citation xml:lang="en">Jia G., Hill M.A., Sowers J.R. Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity. Circ Res. 2018;122(4):624-638. https://doi.org/10.1161/CIRCRESAHA.117.311586</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Jia G., DeMarco V.G., Sowers J.R. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144-153. https://doi.org/10.1038/nrendo.2015.216</mixed-citation><mixed-citation xml:lang="en">Jia G., DeMarco V.G., Sowers J.R. Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2016;12(3):144-153. https://doi.org/10.1038/nrendo.2015.216</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mellor K.M., Bell J.R., Ritchie R.H., Delbridge L.M. Myocardial insulin resistance, metabolic stress and autophagy in diabetes. Clin Exp Pharmacol Physiol. 2013;40(1):56-61. https://doi.org/10.1111/j.1440-1681.2012.05738.x</mixed-citation><mixed-citation xml:lang="en">Mellor K.M., Bell J.R., Ritchie R.H., Delbridge L.M. Myocardial insulin resistance, metabolic stress and autophagy in diabetes. Clin Exp Pharmacol Physiol. 2013;40(1):56-61. https://doi.org/10.1111/j.1440-1681.2012.05738.x</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Guo R., Nair S. Role of microRNA in diabetic cardiomyopathy: From mechanism to intervention. Biochim Biophys Acta Mol Basis Dis. 2017;1863(8):2070-2077. https://doi.org/10.1016/j.bbadis.2017.03.013</mixed-citation><mixed-citation xml:lang="en">Guo R., Nair S. Role of microRNA in diabetic cardiomyopathy: From mechanism to intervention. Biochim Biophys Acta Mol Basis Dis. 2017;1863(8):2070-2077. https://doi.org/10.1016/j.bbadis.2017.03.013</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Borghetti G., von Lewinski D., Eaton D..M, Sourij H., Houser S.R., Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514. https://doi.org/10.3389/fphys.2018.01514</mixed-citation><mixed-citation xml:lang="en">Borghetti G., von Lewinski D., Eaton D..M, Sourij H., Houser S.R., Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514. https://doi.org/10.3389/fphys.2018.01514</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Konduracka E., Cieslik G., Galicka-Latala D., Rostoff P., Pietrucha A., Latacz P., et al. Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study. Acta Diabetol. 2013;50(4):597-606. https://doi.org/10.1007/s00592-013-0455-0</mixed-citation><mixed-citation xml:lang="en">Konduracka E., Cieslik G., Galicka-Latala D., Rostoff P., Pietrucha A., Latacz P., et al. Myocardial dysfunction and chronic heart failure in patients with long-lasting type 1 diabetes: a 7-year prospective cohort study. Acta Diabetol. 2013;50(4):597-606. https://doi.org/10.1007/s00592-013-0455-0</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dandamudi S., Slusser J., Mahoney D.W., Redfield M.M., Rodeheffer R.J., Chen H.H. The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota. J Card Fail. 2014;20(5):304-9. https://doi.org/10.1016/j.cardfail.2014.02.007</mixed-citation><mixed-citation xml:lang="en">Dandamudi S., Slusser J., Mahoney D.W., Redfield M.M., Rodeheffer R.J., Chen H.H. The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota. J Card Fail. 2014;20(5):304-9. https://doi.org/10.1016/j.cardfail.2014.02.007</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Караваев П. Г., Веклич А. С., Козиолова Н. А. Диабетическая кардиомиопатия: особенности сердечно-сосудистого ремоделирования. Российский кардиологический журнал. 2019;24(11):42–47. https://doi.org/10.15829/1560-4071-2019-11-42-47</mixed-citation><mixed-citation xml:lang="en">Караваев П. Г., Веклич А. С., Козиолова Н. А. Диабетическая кардиомиопатия: особенности сердечно-сосудистого ремоделирования. Российский кардиологический журнал. 2019;24(11):42–47. https://doi.org/10.15829/1560-4071-2019-11-42-47</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kenny H.C., Abel E.D. Heart Failure in Type 2 Diabetes Mellitus. Circ Res. 2019;124(1):121-141. https://doi.org/10.1161/CIRCRESAHA.118.311371</mixed-citation><mixed-citation xml:lang="en">Kenny H.C., Abel E.D. Heart Failure in Type 2 Diabetes Mellitus. Circ Res. 2019;124(1):121-141. https://doi.org/10.1161/CIRCRESAHA.118.311371</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Echouffo-Tcheugui J.B., Xu H., DeVore A.D., Schulte P.J., Butler J., Yancy C.W., et al. Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The GuidelinesHeart Failure registry. Am Heart J. 2016;182:9-20. https://doi.org/10.1016/j.ahj.2016.07.025</mixed-citation><mixed-citation xml:lang="en">Echouffo-Tcheugui J.B., Xu H., DeVore A.D., Schulte P.J., Butler J., Yancy C.W., et al. Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The GuidelinesHeart Failure registry. Am Heart J. 2016;182:9-20. https://doi.org/10.1016/j.ahj.2016.07.025</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Loncarevic B., Trifunovic D., Soldatovic I., Vujisic-Tesic B. Silent diabetic cardiomyopathy in everyday practice: a clinical and echocardiographic study. BMC Cardiovasc Disord. 2016;16(1):242. https://doi.org/10.1186/s12872-016-0395-z</mixed-citation><mixed-citation xml:lang="en">Loncarevic B., Trifunovic D., Soldatovic I., Vujisic-Tesic B. Silent diabetic cardiomyopathy in everyday practice: a clinical and echocardiographic study. BMC Cardiovasc Disord. 2016;16(1):242. https://doi.org/10.1186/s12872-016-0395-z</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Seferović P.M., Paulus W.J. Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes. Eur Heart J. 2015;36(27):1718-1727c. https://doi.org/10.1093/eurheartj/ehv134/</mixed-citation><mixed-citation xml:lang="en">Seferović P.M., Paulus W.J. Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes. Eur Heart J. 2015;36(27):1718-1727c. https://doi.org/10.1093/eurheartj/ehv134/</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Fang Z.Y., Prins J.B., Marwick T.H. Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev. 2004;25(4):543-567. https://doi.org/10.1210/er.2003-0012</mixed-citation><mixed-citation xml:lang="en">Fang Z.Y., Prins J.B., Marwick T.H. Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev. 2004;25(4):543-567. https://doi.org/10.1210/er.2003-0012</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Negishi K. Echocardiographic feature of diabetic cardiomyopathy: where are we now? Cardiovasc Diagn Ther. 2018;8(1):47-56. https://doi.org/10.21037/cdt.2018.01.03</mixed-citation><mixed-citation xml:lang="en">Negishi K. Echocardiographic feature of diabetic cardiomyopathy: where are we now? Cardiovasc Diagn Ther. 2018;8(1):47-56. https://doi.org/10.21037/cdt.2018.01.03</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Alonso N., Moliner P., Mauricio D. Pathogenesis, Clinical Features and Treatment of Diabetic Cardiomyopathy. Adv Exp Med Biol. 2018;1067:197-217. https://doi.org/10.1007/5584_2017_105</mixed-citation><mixed-citation xml:lang="en">Alonso N., Moliner P., Mauricio D. Pathogenesis, Clinical Features and Treatment of Diabetic Cardiomyopathy. Adv Exp Med Biol. 2018;1067:197-217. https://doi.org/10.1007/5584_2017_105</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gil K.E., Pawlak A., Gil R.J., Frontczak-Baniewicz M., Bil J. The role of invasive diagnostics and its impact on the treatment of dilated cardiomyopathy: A systematic review. Adv Med Sci. 2016;61(2):331-343. https://doi.org/10.1016/j.advms.2016.07.001</mixed-citation><mixed-citation xml:lang="en">Gil K.E., Pawlak A., Gil R.J., Frontczak-Baniewicz M., Bil J. The role of invasive diagnostics and its impact on the treatment of dilated cardiomyopathy: A systematic review. Adv Med Sci. 2016;61(2):331-343. https://doi.org/10.1016/j.advms.2016.07.001</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Guo R., Nair S. Role of microRNA in diabetic cardiomyopathy: From mechanism to intervention. Biochim Biophys Acta Mol Basis Dis. 2017;1863(8):2070-2077. https://doi.org/10.1016/j.bbadis.2017.03.013</mixed-citation><mixed-citation xml:lang="en">Guo R., Nair S. Role of microRNA in diabetic cardiomyopathy: From mechanism to intervention. Biochim Biophys Acta Mol Basis Dis. 2017;1863(8):2070-2077. https://doi.org/10.1016/j.bbadis.2017.03.013</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ghosh N., Katare R. Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides. Cardiovasc Diabetol. 2018;17(1):43. https://doi.org/10.1186/s12933-018-0684-1</mixed-citation><mixed-citation xml:lang="en">Ghosh N., Katare R. Molecular mechanism of diabetic cardiomyopathy and modulation of microRNA function by synthetic oligonucleotides. Cardiovasc Diabetol. 2018;17(1):43. https://doi.org/10.1186/s12933-018-0684-1</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Hafstad A.D., Boardman N., Aasum E. How exercise may amend metabolic disturbances in diabetic cardiomyopathy. Antioxid Redox Signal. 2015;22(17):1587- 1605. https://doi.org/10.1089/ars.2015.6304</mixed-citation><mixed-citation xml:lang="en">Hafstad A.D., Boardman N., Aasum E. How exercise may amend metabolic disturbances in diabetic cardiomyopathy. Antioxid Redox Signal. 2015;22(17):1587- 1605. https://doi.org/10.1089/ars.2015.6304</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Waldman M., Cohen K., Yadin D., Nudelman V., Gorfil D., Laniado-Schwartzman M., et al. Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'. Cardiovasc Diabetol. 2018;17(1):111. https://doi.org/10.1186/s12933-018-0754-4</mixed-citation><mixed-citation xml:lang="en">Waldman M., Cohen K., Yadin D., Nudelman V., Gorfil D., Laniado-Schwartzman M., et al. Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving 'SIRT1 and PGC-1α'. Cardiovasc Diabetol. 2018;17(1):111. https://doi.org/10.1186/s12933-018-0754-4</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Q., Thompson J., Hu Y., Das A., Lesnefsky EJ. Metformin attenuates ER stress-induced mitochondrial dysfunction. Transl Res. 2017;190:40-50. https://doi.org/10.1016/j.trsl.2017.09.003</mixed-citation><mixed-citation xml:lang="en">Chen Q., Thompson J., Hu Y., Das A., Lesnefsky EJ. Metformin attenuates ER stress-induced mitochondrial dysfunction. Transl Res. 2017;190:40-50. https://doi.org/10.1016/j.trsl.2017.09.003</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Borghetti G., von Lewinski D., Eaton D.M., Sourij H., Houser S.R., Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514. https://doi.org/10.3389/fphys.2018.01514</mixed-citation><mixed-citation xml:lang="en">Borghetti G., von Lewinski D., Eaton D.M., Sourij H., Houser S.R., Wallner M. Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol. 2018;9:1514. https://doi.org/10.3389/fphys.2018.01514</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Wu L., Wang K., Wang W., Wen Z., Wang P., Liu L., Wang D.W. Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway. Aging Cell. 2018;17(4):e12763. https://doi.org/10.1111/acel.12763</mixed-citation><mixed-citation xml:lang="en">Wu L., Wang K., Wang W., Wen Z., Wang P., Liu L., Wang D.W. Glucagon-like peptide-1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway. Aging Cell. 2018;17(4):e12763. https://doi.org/10.1111/acel.12763</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Levelt E., Gulsin G., Neubauer S., McCann G.P. MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review. Eur J Endocrinol. 2018;178(4):R127-R139. https://doi.org/10.1530/EJE-17-0724</mixed-citation><mixed-citation xml:lang="en">Levelt E., Gulsin G., Neubauer S., McCann G.P. MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review. Eur J Endocrinol. 2018;178(4):R127-R139. https://doi.org/10.1530/EJE-17-0724</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pan G., Deshpande M., Pang H., Palaniyandi S.S. Precision medicine approach: Empagliflozin for diabetic cardiomyopathy in mice with aldehyde dehydrogenase (ALDH) 2 * 2 mutation, a specific genetic mutation in millions of East Asians. Eur J Pharmacol. 2018;839:76-81. https://doi.org/10.1016/j.ejphar.2018.09.021</mixed-citation><mixed-citation xml:lang="en">Pan G., Deshpande M., Pang H., Palaniyandi S.S. Precision medicine approach: Empagliflozin for diabetic cardiomyopathy in mice with aldehyde dehydrogenase (ALDH) 2 * 2 mutation, a specific genetic mutation in millions of East Asians. Eur J Pharmacol. 2018;839:76-81. https://doi.org/10.1016/j.ejphar.2018.09.021</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Liu W., Gong W., He M., Liu Y., Yang Y., Wang M., et al. Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats. J Diabetes Res. 2018;2018:9232065. https://doi.org/10.1155/2018/9232065</mixed-citation><mixed-citation xml:lang="en">Liu W., Gong W., He M., Liu Y., Yang Y., Wang M., et al. Spironolactone Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats. J Diabetes Res. 2018;2018:9232065. https://doi.org/10.1155/2018/9232065</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sivasankar D., George M., Sriram D.K. Novel approaches in the treatment of diabetic cardiomyopathy. Biomed Pharmacother. 2018;106:1039-1045. https://doi.org/10.1016/j.biopha.2018.07.051</mixed-citation><mixed-citation xml:lang="en">Sivasankar D., George M., Sriram D.K. Novel approaches in the treatment of diabetic cardiomyopathy. Biomed Pharmacother. 2018;106:1039-1045. https://doi.org/10.1016/j.biopha.2018.07.051</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Yilmaz S., Canpolat U., Aydogdu S., Abboud H.E. Diabetic Cardiomyopathy; Summary of 41 Years. Korean Circ J. 2015;45(4):266-272. https://doi.org/10.4070/kcj.2015.45.4.266</mixed-citation><mixed-citation xml:lang="en">Yilmaz S., Canpolat U., Aydogdu S., Abboud H.E. Diabetic Cardiomyopathy; Summary of 41 Years. Korean Circ J. 2015;45(4):266-272. https://doi.org/10.4070/kcj.2015.45.4.266</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Di Luigi L., Corinaldesi C., Colletti M., Scolletta S., Antinozzi C., Vannelli G.B., et al. Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy. Inflammation. 2016;39(3):1238- 52. https://doi.org/10.1007/s10753-016-0359-6</mixed-citation><mixed-citation xml:lang="en">Di Luigi L., Corinaldesi C., Colletti M., Scolletta S., Antinozzi C., Vannelli G.B., et al. Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy. Inflammation. 2016;39(3):1238- 52. https://doi.org/10.1007/s10753-016-0359-6</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Carillion A., Feldman S., Na N., Biais M., Carpentier W., Birenbaum A., et al. Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy. PLoS One. 2017;12(7):e0180103. https://doi.org/10.1371/journal.pone.0180103</mixed-citation><mixed-citation xml:lang="en">Carillion A., Feldman S., Na N., Biais M., Carpentier W., Birenbaum A., et al. Atorvastatin reduces β-Adrenergic dysfunction in rats with diabetic cardiomyopathy. PLoS One. 2017;12(7):e0180103. https://doi.org/10.1371/journal.pone.0180103</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Yang H., Feng A., Lin S., Yu L., Lin X., Yan X., et al. Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart. Cell Death Dis. 2018;9(2):227. https://doi.org/10.1038/s41419-018-0307-5</mixed-citation><mixed-citation xml:lang="en">Yang H., Feng A., Lin S., Yu L., Lin X., Yan X., et al. Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart. Cell Death Dis. 2018;9(2):227. https://doi.org/10.1038/s41419-018-0307-5</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L., Ding W.Y., Wang Z.H., Tang M.X., Wang F., Li Y., et al. Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy. J Transl Med. 2016;14(1):109. https://doi.org/10.1186/s12967-016-0849-1</mixed-citation><mixed-citation xml:lang="en">Zhang L., Ding W.Y., Wang Z.H., Tang M.X., Wang F., Li Y., et al. Early administration of trimetazidine attenuates diabetic cardiomyopathy in rats by alleviating fibrosis, reducing apoptosis and enhancing autophagy. J Transl Med. 2016;14(1):109. https://doi.org/10.1186/s12967-016-0849-1</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Gollmer J., Zirlik A., Bugger H. Mitochondrial Mechanisms in Diabetic Cardiomyopathy. Diabetes Metab J. 2020;44(1):33- 53. https://doi.org/10.4093/dmj.2019.0185</mixed-citation><mixed-citation xml:lang="en">Gollmer J., Zirlik A., Bugger H. Mitochondrial Mechanisms in Diabetic Cardiomyopathy. Diabetes Metab J. 2020;44(1):33- 53. https://doi.org/10.4093/dmj.2019.0185</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Tian J., Zhao Y., Liu Y., Liu Y., Chen K., Lyu S. Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective. Oxid Med Cell Longev. 2017;2017:8214541. https://doi.org/10.1155/2017/8214541</mixed-citation><mixed-citation xml:lang="en">Tian J., Zhao Y., Liu Y., Liu Y., Chen K., Lyu S. Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective. Oxid Med Cell Longev. 2017;2017:8214541. https://doi.org/10.1155/2017/8214541</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Fang W.J., Wang C.J., He Y., Zhou Y.L., Peng X.D., Liu S.K. Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation. Acta Pharmacol Sin. 2018;39(1):59-73. https://doi.org/10.1038/aps.2017.50</mixed-citation><mixed-citation xml:lang="en">Fang W.J., Wang C.J., He Y., Zhou Y.L., Peng X.D., Liu S.K. Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation. Acta Pharmacol Sin. 2018;39(1):59-73. https://doi.org/10.1038/aps.2017.50</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wen H.L., Liang Z.S., Zhang R., Yang K. Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy. Cardiovasc Diabetol. 2013;12:50. https://doi.org/10.1186/1475-2840-12-50</mixed-citation><mixed-citation xml:lang="en">Wen H.L., Liang Z.S., Zhang R., Yang K. Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy. Cardiovasc Diabetol. 2013;12:50. https://doi.org/10.1186/1475-2840-12-50</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Huynh K., Bernardo B.C., McMullen J.R., Ritchie R.H. Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacol Ther. 2014;142(3):375-415. https://doi.org/10.1016/j.pharmthera.2014.01.003.</mixed-citation><mixed-citation xml:lang="en">Huynh K., Bernardo B.C., McMullen J.R., Ritchie R.H. Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacol Ther. 2014;142(3):375-415. https://doi.org/10.1016/j.pharmthera.2014.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Park I.H., Song Y.S., Joo H.W., Shen G.Y., Seong J.H., Shin N.K., et al. Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy. Diabetes Metab J. 2020;44(1):173-185. https://doi.org/10.4093/dmj.2018.0211</mixed-citation><mixed-citation xml:lang="en">Park I.H., Song Y.S., Joo H.W., Shen G.Y., Seong J.H., Shin N.K., et al. Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy. Diabetes Metab J. 2020;44(1):173-185. https://doi.org/10.4093/dmj.2018.0211</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
