therapeuticЮжно-Российский журнал терапевтической практикиSouth Russian Journal of Therapeutic Practice2712-8156РостГМУ10.21886/2712-8156-2023-4-4-83-88therapeutic-452Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHОценка эффективности применения железа карбоксимальтозата на поздних сроках беременности и в послеродовом периодеEvaluation of the effectiveness of the use of iron carboxymaltosate in late pregnancy and in the postpartum periodБарцицМ. К.BartsitsM. K.

Барциц Марица Кибеевна - врач-клинический фармаколог.

Ростов-на-Дону

Maritsa K. Bartsits - clinical pharmacologist, State budgetary institution Rostov region “Perinatal center”.

Rostov-on-Don

Maritsab89@gmail.comhttps://orcid.org/0000-0003-4625-6186СафроненкоА. В.SafronenkoA. V.

Сафроненко Андрей Владимирович - д.м.н., доц., заведующий кафедрой фармакологии и клинической фармакологии.

Ростов-на-Дону

Andrey V. Safronenko - Dr. Sci. (Med.), Docent, Head of the Department of pharmacology and clinical pharmacology, Federal State Budget Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Health of the Russian Federation.

Rostov-on-Don

andrejsaf@mail.ruhttps://orcid.org/0000-0003-0627-8372ГанцгорнЕ. В.GantsgornE. V.

Ганцгорн Елена Владимировна - к.м.н., доц., доцент кафедры фармакологии и клинической фармакологии.

Ростов-на-Дону

Elena V. Gantsgorn - Cand. Sci. (Med.), Docent, Associate professor of the Department of pharmacology and clinical pharmacology, Federal State Budget Educational Institution of Higher Education “Rostov State Medical University” of the Ministry of Health of the Russian Federation.

Rostov-on-Don

gantsgorn@inbox.ruУманскийМ. Н.UmanskyM. N.

Уманский Максим Николаевич - к.м.н., главный врач.

Ростов-на-Дону

Maxim N. Umansky - Candidate of Medical Sciences, Chief Physician of the State budgetary institution Rostov region “Perinatal Center”.

Rostov-on-Don

Dr_uman@mail.ruГБУ РО «Перинатальный центр»РоссияPerinatal CenterRussian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian Federation202325122023448388Copyright © Барциц М.К., Сафроненко А.В., Ганцгорн Е.В., Уманский М.Н., 20232023Барциц М.К., Сафроненко А.В., Ганцгорн Е.В., Уманский М.Н.Bartsits M.K., Safronenko A.V., Gantsgorn E.V., Umansky M.N.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.therapeutic-j.ru/jour/article/view/452

Цель: оценить эффективность применения железа карбоксимальтозата на поздних сроках беременности и в послеродовом периоде. Материалы и методы: проведено динамическое наблюдение в амбулаторных условиях эффективности железа карбоксимальтозата у 46 беременных с диагнозом «Анемия, латентный дефицит железа ввиду отсутствия положительной динамики на фоне приёма пероральной формы препаратов железа», предъявляющих жалобы на учащенное сердцебиение, одышку при минимальной физической нагрузке, слабость. Оценка проводилась по уровню гемоглобина (Hb), ферритина через месяц после проведённого лечения высокодозным препаратом железа внутривенно капельно. Период наблюдения — третий триместр беременности, на 2-е сутки и через месяц после родоразрешения. Результаты: проведённое лечение железа карбоксимальтозатом привело к увеличению уровня Hb на 18±3 г/л и ферритина на 70±35 мкг/л через месяц после инфузии, улучшению клинического состояния. Вывод: применение железа карбоксимальтозата на поздних сроках беременности позволяет в короткие сроки нормализовать и длительно, уже в течение послеродового периода, сохранить целевые значения уровня Hb и ферритина, а также улучшить качество жизни пациенток.

Objective: to evaluate the effectiveness of the use of iron carboxymaltosate in late pregnancy and in the postpartum period. Materials and methods: dynamic observation of the effectiveness of iron carboxymaltosate in 46 pregnant women diagnosed with anemia, latent iron deficiency due to the lack of positive dynamics against the background of taking oral forms of iron preparations, complaining of palpitations, shortness of breath with minimal physical exertion, weakness. The assessment was carried out by the level of hemoglobin (Hb), ferritin a month after the treatment with a high-dose iron preparation intravenously drip. The follow–up period is the third trimester of pregnancy, 2 days after delivery, a month after delivery. Results: the treatment with iron of carboxymaltosate led to an increase in the Hb level of 18±3 g/l, the ferritin level of 70±35 mcg/l a month after the infusion, and an improvement in the clinical condition. Conclusion: the use of iron carboxymaltose in the late stages of pregnancy allows to quickly normalize and maintain target values of hemoglobin and ferritin levels for a long time, already during the postpartum period, as well as improve the quality of life of women.

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The authors declare that there are no conflicts of interest present.