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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2024-5-3-46-53</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-523</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Влияние уровня липопротеида (а) на долгосрочные исходы у пациентов с острым коронарным синдромом и однососудистым поражением коронарных артерий</article-title><trans-title-group xml:lang="en"><trans-title>The impact of lipoprotein (a) levels on long-term outcomes in patients with acute coronary syndrome and single-vessel coronary artery disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5866-506X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Намитоков</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Namitokov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Намитоков Алим Муратович, к.м.н., заведующий кардиологическим отделением №2 для больных с инфарктом миокарда; доцент кафедры терапии №1</p><p>Краснодар </p></bio><bio xml:lang="en"><p>Alim M. Namitokov, Cand. Sci. (Med.), Head of Cardiology Department No. 2 for Patients with Myocardial Infarction; Associate Professor of the Therapy Department No. 1</p><p>Krasnodar </p></bio><email xlink:type="simple">namitokov.alim@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7538-0437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кручинова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruchinova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кручинова София Владимировна, к.м.н., врач-кардиолог кардиологического отделения №2 для больных с инфарктом миокарда; ассистент кафедры терапии No 1</p><p>Краснодар </p></bio><bio xml:lang="en"><p>Sofia V. Kruchinova, Cand. Sci. (Med.), Cardiologist of Cardiology Department No. 2 for Patients with Myocardial Infarction; Assistant of the Department of Therapy No. 1</p><p>Krasnodar </p></bio><email xlink:type="simple">skruchinova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-7063-3798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гендугова</surname><given-names>М. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gendugova</surname><given-names>M. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гендугова Милана Нургалиевна, врач-кардиолог приемного отделения; аспирант кафедры терапии No 1</p><p>Краснодар </p></bio><bio xml:lang="en"><p>Milana N. Gendugova, cardiologist of the admission department; Postgraduate student of the Department of Therapy No. 1</p><p>Krasnodar </p></bio><email xlink:type="simple">milana.gendugova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-2868-5973</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Градовская</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gradovskaya</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Градовская Мария Викторовна, врач ультразвуковой диагностики</p><p>Краснодар </p></bio><bio xml:lang="en"><p>Maria V. Gradovskaya, ultrasound diagnostics doctor</p><p>Krasnodar </p></bio><email xlink:type="simple">mar-di-gra@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9766-1811</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гилевич</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gilevich</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гилевич Ирина Викторовна, к.м.н., заведующий лабораторией разработки и изучения новых технологий лечения заболеваний; ассистент кафедры онкологии с курсом торакальной хирургии ФПК и ППС</p><p>Краснодар </p></bio><bio xml:lang="en"><p>Irina V. Gilevich, Cand. Sci. (Med.), Head of the Laboratory for the Development and Study of New Technologies for the Treatment of Diseases; Assistant of the Department of Oncology with the Course of Thoracic Surgery, Faculty of Advanced Training and PPS</p><p>Krasnodar </p></bio><email xlink:type="simple">giliv@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница № 1 им. пр. С.В. Очаповского» Минздрава Краснодарского края ; ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России<country>Россия</country></aff><aff xml:lang="en">Scientific Research Institute - Regional Clinical Hospital № 1 n.a. prof. S.V. Ochapovsky ; Kuban State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница № 1 им. пр. С.В. Очаповского» Минздрава Краснодарского края<country>Россия</country></aff><aff xml:lang="en">Scientific Research Institute - Regional Clinical Hospital № 1 n.a. prof. S.V. Ochapovsky<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2024</year></pub-date><volume>5</volume><issue>3</issue><fpage>46</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Намитоков А.М., Кручинова С.В., Гендугова М.Н., Градовская М.В., Гилевич И.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Намитоков А.М., Кручинова С.В., Гендугова М.Н., Градовская М.В., Гилевич И.В.</copyright-holder><copyright-holder xml:lang="en">Namitokov A.M., Kruchinova S.V., Gendugova M.N., Gradovskaya M.V., Gilevich I.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/523">https://www.therapeutic-j.ru/jour/article/view/523</self-uri><abstract><p>Цель: оценить влияние уровней липопротеида (а) [Лп(а)] на долгосрочные исходы у пациентов с острым коронарным синдромом (ОКС) и однососудистым поражением коронарных артерий. Материалы и методы: в исследование были включены 110 пациентов с ОКС и однососудистым поражением коронарных артерий. Пациенты были разделены на две группы в зависимости от уровня Лп(а): Лп(а) &gt; 50 мг/дл (n=22) и Лп(а) &lt; 50 мг/дл (n=88). Основные исходы включали выживаемость и частоту повторных сердечно-сосудистых событий через 6, 12 и 36 месяцев. Статистический анализ включал t-тест, критерий хи-квадрат, метод Каплана-Мейера и многофакторную регрессию Кокса. Результаты: через 36 месяцев у пациентов с высоким уровнем Лп(а) была значительно выше частота повторных инфарктов миокарда (50% против 34.1%, p &lt; 0.001) и смертность от всех причин (59.1% против 23.9%, p &lt; 0.001) по сравнению с пациентами с нормальным уровнем Лп(а). Заключение: высокий уровень Лп(а) является значимым прогностическим фактором ухудшения долгосрочных исходов у пациентов с ОКС и однососудистым поражением коронарных артерий. Измерение уровня Лп(а) может способствовать улучшению стратегии ведения таких пациентов</p></abstract><trans-abstract xml:lang="en"><p>Objective: to evaluate the impact of lipoprotein (a) [Lp(a)] levels on long-term outcomes in patients with acute coronary syndrome (ACS) and single-vessel coronary artery disease. Materials and methods: the study included 110 patients diagnosed with ACS and single-vessel coronary artery disease. Patients were divided into two groups based on Lp(a) levels: Lp(a) &gt; 50 mg/dL (n=22) and Lp(a) &lt; 50 mg/dL (n=88). Primary outcomes included survival and the frequency of recurrent cardiovascular events at 6, 12, and 36 months. Statistical analysis included t-test, chi-square test, Kaplan-Meier method, and Cox multivariate regression. Results: at 36 months, patients with high Lp(a) levels had significantly higher rates of recurrent myocardial infarctions (50% vs. 34.1%, p &lt; 0.001) and all-cause mortality (59.1% vs. 23.9%, p &lt; 0.001) compared to patients with normal Lp(a) levels. Conclusion: high Lp(a) levels are a significant prognostic factor for worse long-term outcomes in patients with ACS and single-vessel coronary artery disease. Measuring Lp(a) levels may improve management strategies for these patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>липопротеид (а)</kwd><kwd>острый коронарный синдром</kwd><kwd>инфаркт миокарда</kwd><kwd>однососудистое поражение коронарных артерий</kwd><kwd>прогностический фактор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lipoprotein (a)</kwd><kwd>acute coronary syndrome</kwd><kwd>myocardial infarction</kwd><kwd>single-vessel coronary artery disease</kwd><kwd>prognostic factor</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Исследование проведено при поддержке кубанского научного фонда в рамках научного проекта № мфи-20.1/63.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med. 1999;340(2):115-126. 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