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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">therapeutic</journal-id><journal-title-group><journal-title xml:lang="ru">Южно-Российский журнал терапевтической практики</journal-title><trans-title-group xml:lang="en"><trans-title>South Russian Journal of Therapeutic Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2712-8156</issn><issn pub-type="epub">3033-8344</issn><publisher><publisher-name>РостГМУ</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21886/2712-8156-2025-6-3-42-51</article-id><article-id custom-type="elpub" pub-id-type="custom">therapeutic-654</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Факторы, ассоциированные со снижением фракции выброса левого желудочка у пациентов с первичным инфарктом миокарда</article-title><trans-title-group xml:lang="en"><trans-title>Factors associated with reduced left ventricular ejection fraction in patients with primary myocardial infarction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-0159-9182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карибова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karibova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Васильевна Карибова, аспирант, врач-кардиолог</p><p>кафедра терапии № 1</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Mariya V. Karibova, postgraduate student, cardiologist</p><p>Department of Therapy No. 1</p><p>Krasnodar</p></bio><email xlink:type="simple">mari.karibova96@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7538-0437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кручинова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruchinova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>София Владимировна Кручинова, к. м. н., доцент, врач-кардиолог</p><p>кафедра терапии № 1</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Sofiya V. Kruchinova, Cand. Sci. (Med.), Associate Professor, cardiologist</p><p>Department of Therapy No. 1</p><p>Krasnodar</p></bio><email xlink:type="simple">skruchinova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8600-0199</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Космачева</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosmacheva</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Дмитриевна Космачева, д. м. н., проф., зав. кафедрой, зам. главноговрача по лечебной работе</p><p>кафедра терапии № 1</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Elena D. Kosmacheva, Dr. Sci. (Med.), Professor, Head of the Department, Deputy Chief Physician for Medical Work</p><p>Department of Therapy No. 1</p><p>Krasnodar</p></bio><email xlink:type="simple">kosmachova_h@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; ГБУЗ «Научно-исследовательский институт – Краевая клиническая больница № 1 им. проф. С.В. Очаповского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2025</year></pub-date><volume>6</volume><issue>3</issue><fpage>42</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карибова М.В., Кручинова С.В., Космачева Е.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Карибова М.В., Кручинова С.В., Космачева Е.Д.</copyright-holder><copyright-holder xml:lang="en">Karibova M.V., Kruchinova S.V., Kosmacheva E.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.therapeutic-j.ru/jour/article/view/654">https://www.therapeutic-j.ru/jour/article/view/654</self-uri><abstract><sec><title>   Цель</title><p>   Цель: на основе данных тотального регистра острого коронарного синдрома (ОКС) по Краснодарскому краю определить факторы, ассоциированные со снижением фракции выброса левого желудочка (ФВ ЛЖ) у пациентов с первичным инфарктом миокарда (ИМ).</p></sec><sec><title>   Материалы и методы</title><p>   Материалы и методы: проведено рестроспективное исследование 5655 пациентов с первичным ИМ, включённых в тотальный регистр ОКС по Краснодарскому краю за период с 2022 г. по 2024 г. Изучена связь между показателями ФВ ЛЖ и клинико-анамнестическими и диагностическими данными пациентов. Значения ФВ ЛЖ оценивались методом Симпсона перед выпиской из стационара или ранее (в случае наступления госпитального летального исхода). В зависимости от показателя ФВ ЛЖ все пациенты были разделены на группы с низкой (≤ 40 %) ФВ ЛЖ (n = 1125), умеренно низкой (41-49 %) ФВ ЛЖ (n = 1258) и сохранённой (≥ 50 %) ФВ ЛЖ (n = 3272).</p></sec><sec><title>   Результаты</title><p>   Результаты: проанализированы данные 5655 пациентов, включённых в тотальный регистр ОКС по Краснодарскому краю за период с 2022 г. по 2024 г. В качестве предикторов снижения ФВ ЛЖ у пациентов с первичным ИМ выявлены такие факторы, как наличие в анамнезе курения, хронической болезни почек, артериальной гипертензии и периферического атеросклероза, повышение тропонина, креатинина &gt;130 мкмоль/л и глюкозы &gt; 15 ммоль/л при поступлении, по данным лабораторных исследований крови, элевация сегмента ST и формирование патологического зубца Q на электрокардиограмме (ЭКГ), а также острая сердечная недостаточность (ОСН) II–IV класса по Killip и наличие ранних осложнений ИМ.</p></sec><sec><title>   Заключение</title><p>   Заключение: наличие курения, хронической болезни почек, артериальной гипертензии и периферического атеросклероза в анамнезе, повышение тропонина, креатинина &gt; 130 мкмоль/л и глюкозы &gt; 15 ммоль/л, элевация сегмента ST, формирование патологического зубца Q, явления ОСН II–IV класса по Killip и возникновение ранних осложнений ассоциированы со снижением ФВ ЛЖ у пациентов с ИМ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   Objective</title><p>   Objective: based on the data from the total register of acute coronary syndrome (ACS) in the Krasnodar Territory, identify the factors associated with reduced LV EF in patients with primary acute myocardial infarction (MI).</p></sec><sec><title>   Materials and methods</title><p>   Materials and methods: a retrospective study was conducted on 5,655 patients with primary MI included in the total ACS registry in the Krasnodar Territory from 2022 to 2024. The study examined the relationship between LV EF and the clinical, anamnestic, and diagnostic data of the patients. LV EF values were assessed using the Simpson method before discharge from the hospital or earlier in case of hospital-acquired death. Depending on the LV EF, all patients were divided into groups with low (≤ 40 %) LV EF (n = 1125), moderately low (41-49 %) LV EF (n = 1258), and preserved (≥ 50 %) LV EF (n = 3272).</p></sec><sec><title>   Results</title><p>   Results: the data of 5,655 patients included in the total ACS registry in the Krasnodar Territory for the period from 2022 to 2024 were analyzed. Factors such as a history of smoking, chronic kidney disease, hypertension, and peripheral atherosclerosis, increased troponin, creatinine &gt; 130 mmol/l, and glucose &gt; 15 mmol/l upon admission according to laboratory blood tests, and ST segment elevation and the formation of a pathological Q wave on an electrocardiogram, as well as acute heart failure (AHF) of class II–IV according to Killip and the presence of early complications of MI were identified as predictors of a decrease in LVEF in patients with primary MI.</p></sec><sec><title>   Conclusions</title><p>   Conclusions: presence of smoking, chronic kidney disease, arterial hypertension and peripheral atherosclerosis in the anamnesis, increase in troponin, creatinine &gt; 130 μmol/L and glucose &gt; 15 mmol/L, ST segment elevation, formation of pathological Q-wave, the phenomena of OSN II–IV class according to Killip, and the presence of early complications are associated with a decrease in LV EF in patients with MI.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инфаркт миокарда</kwd><kwd>регистр острого коронарного синдрома</kwd><kwd>фракция выброса левого желудочка</kwd><kwd>сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>myocardial infarction</kwd><kwd>acute coronary syndrome registry</kwd><kwd>left ventricular ejection fraction</kwd><kwd>heart failure</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование не имело спонсорской поддержки</funding-statement><funding-statement xml:lang="en">The study had no sponsorship support</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Smeets M, Vaes B, Mamouris P, Van Den Akker M, Van Pottelbergh G, Goderis G, et al. 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