THE EFFECT OF THIOTRIAZOLINE ON ENERGY PRODUCTION IN CONDITIONS OF CHRONIC MYOCARDIAL ISCHEMIA
https://doi.org/10.21886/2712-8156-2020-1-1-84-90
Abstract
Objective: to study molecular effects of thiotriasoline of the patients with coronary heart disease (CHD).
Materials and methods: 60 patients with stable angina of I – III functional classes were compared regarding the effects of thiotriasoline via standard therapy regime (STR), taking into account the activity of basic products level free radical oxidation (FRO) and antioxidant systems (AOS), proteomic protein profile.
Results: in 24 weeks on the background of STR and thiotriasoline there is a revealed statistically reliable growth of glutathione reductase content, reduction of malonic dialdehyde, increase of endothelial lipase detection rate, phosphomevalonatekinase, γ-butyrobetaine hydroxylase, linoleil CoA-desaturase, reduction of delta-5 desaturase.
Conclusion: thiotriasoline possesses cardioprotective activity with antioxidant and cytoprotective effects, reducing free radical products content and raising the activity of antioxidant systems ferments with regard to patients with CHD.
About the Authors
A. A. Kastanayan
Rostov State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof.,
Rostov-on-Don
E. A. Kartashova
Rostov State Medical University
Russian Federation
Russian Federation
Cand. Sci. (Med.)
Rostov-on-Don
E. I. Zheleznyak
Rostov State Medical University
Russian Federation
Russian Federation
Cand. Sci. (Med.)
Rostov-on-Don
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Review
For citations:
Kastanayan A.A., Kartashova E.A., Zheleznyak E.I. THE EFFECT OF THIOTRIAZOLINE ON ENERGY PRODUCTION IN CONDITIONS OF CHRONIC MYOCARDIAL ISCHEMIA. South Russian Journal of Therapeutic Practice. 2020;1(1):84-90. (In Russ.) https://doi.org/10.21886/2712-8156-2020-1-1-84-90
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