Возможности оптимизации терапии хронической сердечной недостаточности с сохраненной фракцией выброса с помощью применения агонистов рецепторов глюкагоноподобного пептида-1

В статье представлен систематический обзор литературы, посвящённый анализу эффективности и безопасности применения агонистов рецепторов глюкагоноподобного пептида-1 (арГПП-1) при хронической сердечной недостаточности (СН) с сохранённой фракцией выброса левого желудочка (ХСНсФВ). Вопрос исследования касался возможностей совместного приёма препаратов из групп ингибиторов натрий-глюкозного котранспортера 2 типа (иНГЛТ2) и арГПП-1. Поиск литературы осуществлялся в системе PubMed. В окончательный анализ вошли 11 исследований, соответствующих изучаемой теме. Согласно анализу, арГПП-1 являются эффективным средством для терапии пациентов с ХСНсФВ, приводя к уменьшению симптомов СН и улучшению качества жизни таких больных. Вопросы одновременного назначения арГПП-1 и иНГЛТ2 достаточно подробно изучены у пациентов с сахарным диабетом 2 типа: продемонстрированы эффективность и безопасность такой комбинации. При отсутствии СД у пациентов с ХСНсФВ оптимизация лечения с использованием класса арГПП-1 требует проведения дополнительных специально спланированных исследований.

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