CLINICAL AND FUNCTIONAL FEATURES OF GASTROESOPHAGEAL REIFLUX DISEASE, COMORBID WITH PEPTIC ULCER DISEASE
https://doi.org/10.21886/2712-8156-2020-1-1-78-83
Abstract
Objective: to study the clinical and functional manifestations of various forms of gastroesophageal reflux disease (GERD) with comorbid peptic ulcer of the duodenum (PUD) and gastric ulcer (GU) to clarify the diagnosis and identify targets for pathogenetic therapy at the stage of primary health care.
Materials and methods: 287 patients with GERD, comorbid with uncomplicated ulcer, were examined. Questioning of patients was carried out, An in-depth endoscopic examination (EGDS) was performed in combination with an acid perfusion test (APT) to detect non-erosive reflux disease (NERD) and gastric endoscopic chromoscopy to determine the acid production of the stomach.
Results: in patients with GERD with comorbid PUD, heartburn and acid regurgitation were more often detected in comparison with NERD. According to the results of chromoscopy, hyperand normochlorhydria were characteristic for patients with PUD, hypochlorhydria - for patients with GU. An acute GERD stage and the frequency of positive CBT are associated with an exacerbation of the PUD. There was a direct correlation between the age of patients and the stage of GERD. Moreover, the age and stage of GERD revealed a direct correlation with a positive APT, which reflects a violation of the permeability of mucosae of the esophagus.
Conclusion: in patients with GERD with comorbid PU, patient-oriented diagnosis may consist of endoscopic chromoscopic determination of stomach acid production and endoscopic APT to confirm NERD and identify GERD phenotypes comorbid with acid-dependent diseases in order to determine treatment tactics.
About the Authors
E. V. Gorban
Kuban State Medical University
Russian Federation
Krasnodar
Russian Federation
Krasnodar
N. V. Korochanskaya
Kuban State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.)
Krasnodar
V. V. Gorban
Kuban State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.)
Krasnodar
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Review
For citations:
Gorban E.V., Korochanskaya N.V., Gorban V.V. CLINICAL AND FUNCTIONAL FEATURES OF GASTROESOPHAGEAL REIFLUX DISEASE, COMORBID WITH PEPTIC ULCER DISEASE. South Russian Journal of Therapeutic Practice. 2020;1(1):78-83. (In Russ.) https://doi.org/10.21886/2712-8156-2020-1-1-78-83
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