Assessment of modifiable risk factors and vascular wall stiffness in young people
https://doi.org/10.21886/2712-8156-2024-5-3-21-27
Abstract
Objective: to study the characteristics of vascular stiffness in young people, taking into account the presence of the main modifiable risk factors (FR) for the development of cardiovascular diseases (CVD). Materials and methods: a survey was conducted of 38 practically healthy young people (18 boys, 20 girls) — university students, whose average age was 19.8±1.45 years. By filling in the modified diagnostic charts, the subjects assessed the presence of the main behavioral CVD disorders. Volumetric sphygmography on the VaSera-1000 device (Fukuda Denschi, Japan) was used to assess the stiffness of the main vessels and blood pressure (BP) levels in the basins of the upper and lower extremities. Results: in the examined individuals, despite their young age and the documented absence of cardio-vascular pathology, all the main cardiovascular diseases were revealed: an increased body mass index (BMI≥25 kg/m2), smoking, psychosocial factors, sedentary lifestyle, unbalanced diet, alcohol consumption, which were present in various combinations. Vascular stiffness indices — the cardio-ankle index and the biological age of the vessels — were within the normal range, while the ankle-shoulder index was reduced in 24% of the students. Conclusion: the results obtained indicate the need for primary prevention of CVD by lifestyle modification, even in young people, since the FR detected in them and the tendency to change vascular stiffness indicators can subsequently act as triggers for the early onset of diseases of the circulatory system
About the Authors
L. V. Arutyunyan
Rostov State Medical University
Russian Federation
Russian Federation
Liana V. Arutyunyan
Rostov-on-Don
A. A. Pirozhenko
Rostov State Medical University
Russian Federation
Russian Federation
Anna A. Pirozhenko
Rostov-on-Don
N. V. Drobotya
Rostov State Medical University
Russian Federation
Russian Federation
Natalya V. Drobotya, Dr. Sci. (Med.)
Rostov-on-Don
V. V. Kaltukova
Rostov State Medical University
Russian Federation
Russian Federation
Valentina V. Kaltukova
Rostov-on-Don
References
1. Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, Bäck M, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227- 3337. Erratum in: Eur Heart J. 2022;43(42):4468. DOI: 10.1093/eurheartj/ehab484
2. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Russian Journal of Cardiology. 2022;27(7):5155. (In Russ.) DOI: 10.15829/1560-4071-2022-5155
3. Troitskaya E.A., Velmakin S.V., Kobalava Z.D. Concept of vascular age: new tool in cardiovascular risk assessment. Arterial’naya Gipertenziya (“Arterial Hypertension”). 2017;23(2):160-171. (In Russ.) DOI: 10.18705/1607-419X-2017-23-2-160-171
4. Chulkov V.S., Gavrilova E.S., Chulkov V.S., Pankova E.D., Lenets E.A., Tkachenko P.E. Primary prevention of cardiovascular disease: focus on improving behavioral risk factors. Russian Journal of Cardiology. 2021;26(3S):4278. (In Russ.) DOI: 10.15829/1560-4071-2021-4278
5. Ding N, Sang Y, Chen J, Ballew SH, Kalbaugh CA, Salameh MJ, et al. Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases. J Am Coll Cardiol. 2019;74(4):498-507. DOI: 10.1016/j.jacc.2019.05.049
6. Chulkov V.S., Lenets E.A., Chulkov V.S., Gavrilova E.S., Minina E.E., Zhdanova O.V. Gender characteristics of the pathogenesis, prevention and treatment of metabolic syndrome. Arterial’naya Gipertenziya (“Arterial Hypertension”). 2020;26(4):371-382. (In Russ.) DOI: 10.18705/1607-419X-2020-26-4-371-382
7. Shlyakhto E.V., Zvartau N.E., Villevalde S.V., Yakovlev A.N., Soloveva A.E., Alieva A.S., et al. Cardiovascular risk management system: prerequisites for developing, organization principles, target groups. Russian Journal of Cardiology. 2019;(11):69-82. (In Russ.) DOI: 10.15829/1560-4071-2019-11-69-82
8. Boytsov S.A., Pogosova N.V., Ansheles A.A., Badtieva V.A., Balakhonova T.V., Barbarash O.L., et al. Cardiovascular prevention 2022. Russian national guidelines. Russian Journal of Cardiology. 2023;28(5):5452. (In Russ.) DOI: 10.15829/1560-4071-2023-5452
9. Evsevyeva M.E., Eremin M.V., Rostovtseva M.V., Fursova E.N., Rusydi A.V., Gal’kova I.Yu., et al. Vascular aging phenotypes based on VaSerа-screening results in young people with hypertension: Place of connective tissue dysplasia. Arterial’naya Gipertenziya (“Arterial Hypertension”). 2021;27(2):188-205. (In Russ.) DOI: 10.18705/1607-419X-2021-27-2-188-205
10. Gielen S, Backer GDe, Piepoli M, Albus C, Astin F, Benlian P.et al. The ESC Textbook of preventive cardiology. Oxford: University Press; 2016.
11. Burko N.V., Avdeeva I.V., Oleynikov V.E., Boytsov S.A. The Concept of Early Vascular Aging. Rational Pharmacotherapy in Cardiology. 2019;15(5):742-749. (In Russ.) DOI: 10.20996/1819-6446-2019-15-5-742-749
12. Chamnan P, Simmons RK, Khaw KT, Wareham NJ, Griffin SJ. Estimating the population impact of screening strategies for identifying and treating people at high risk of cardiovascular disease: modelling study. BMJ. 2010;340:c1693. DOI: 10.1136/bmj.c1693
13. Nikitin V.S., Saleev V.B., Kanysheva S.V. Unstable first-time angina pectoris at a young age. Zdravookhranenie Chuvashii. 2022;(3):65-70. (In Russ.) DOI: 10.25589/GIDUV.2022.55.21.001
14. Bocharov A.V., Popov L.V., Mittsiev A.K., Lagkuev M.D. Acute coronary syndrome in patients under 35 years old. Clinical Medicine (Russian Journal). 2021;99(7-8):440-443. (In Russ.) DOI: 10.30629/0023-2149-2021-99-7-8-440-443
15. Vasan RS, Pan S, Xanthakis V, Beiser A, Larson MG, Seshadri S, et al. Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study. Hypertension. 2022;79(5):1045-1056. DOI: 10.1161/HYPERTENSIONAHA.121.18776
16. Denisov V.I., Pereverzeva K.G., Boyakov D.Y., Chuchunov A.D., Khazov D.A. Myocardial infarction at a young age: risk factors, clinical presentation, features of management in the hospital. Clinical Medicine (Russian Journal). 2021;99(1):58- 62. (In Russ.) DOI: 10.30629/0023-2149-2021-99-1-58-62
17. Evsevyeva M.Y., Eremin M.V., Rostovtseva M.V., Sergeeva O.V., Rusidi A.V., Kudryavtseva V.D., et al. Preventive Screening of Young People from the Perspective of Vascular Aging Phenotypes: the Role of Body Weight. Rational Pharmacotherapy in Cardiology. 2022;18(1):42-48. (In Russ.) DOI: 10.20996/1819-6446-2022-02-14
18. Akopyan A.A., Strazhesko I.D., Klyashtorny V.G., Orlova I.A. Biological vascular age and its relationship with cardiovascular risk factors. Cardiovascular Therapy and Prevention. 2022;21(1):2877. (In Russ.) DOI: 10.15829/1728-8800-2022-2877
19. Aatola H, Koivistoinen T, Tuominen H, Juonala M, Lehtimäki T, Viikari JSA, et al. Influence of Child and Adult Elevated Blood Pressure on Adult Arterial Stiffness: The Cardiovascular Risk in Young Finns Study. Hypertension. 2017;70(3):531-536. DOI: 10.1161/HYPERTENSIONAHA.117.09444
20. Evsevyeva M.Y., Eremin M.V., Rostovtseva M.V., Sergeeva O.V., Rusidi A.V., Kudryavtseva V.D., et al. Preventive Screening of Young People from the Perspective of Vascular Aging Phenotypes: the Role of Body Weight. Rational Pharmacotherapy in Cardiology. 2022;18(1):42-48. (In Russ.) DOI: 10.20996/1819-6446-2022-02-14
21. Rotar O.P., Tolkunova K.M. EVA and SUPERNOVA concepts of vascular aging: ongoing research on damaging and protective risk factors. Arterial’naya Gipertenziya (“Arterial Hypertension”). 2020;26(2):133-145. DOI: 10.18705/1607-419X-2020-26-2-133-145
22. Tshenyatskaya I.V., Drobotya N.V., Pirozhenko A.A., Kaltykova V.V. The incidence of hypertensive conditions and risk factors of cardio-vascular diseases in young people. Bulletin of Pirogov national medical & surgical center. 2012;7(1):118- 121. (In Russ.)eLIBRARY ID: 21752417 EDN: SIAFIF
23. Dudinskaya E.N., Machekhina L.V., Eruslanova K.A., Dogotar O.A., Ryltseva L.P., Lyzlova N.Yu., et al. Antihypertensive therapy: controlling the processes of replicative cell senescence. Russian Journal of Cardiology. 2020;25(3S):3974. DOI: 10.15829/1560-4071-2020-3974
24. Dzau V, Braunwald E. Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement. Am Heart J. 1991;121(4 Pt 1):1244-1263. DOI: 10.1016/0002-8703(91)90694-d
25. Medvedeva E.A., Usova E.I., Solovyova A.E., Dubinina M.V., Villevalde S.V., Zvartau N.E., et al. Patients with hypertension and chronic kidney disease as a priority group for primary prevention programs. Russian Journal of Cardiology. 2024;29(3):5812. (In Russ.) DOI: 10.15829/1560-4071-2024-5812. EDN: LMYMWP
Review
For citations:
Arutyunyan L.V., Pirozhenko A.A., Drobotya N.V., Kaltukova V.V. Assessment of modifiable risk factors and vascular wall stiffness in young people. South Russian Journal of Therapeutic Practice. 2024;5(3):21-27. (In Russ.) https://doi.org/10.21886/2712-8156-2024-5-3-21-27
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