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Recurrence of primary sclerosing cholangitis after liver transplantation, occurring on the background of ulcerative colitis

https://doi.org/10.21886/2712-8156-2025-6-1-95-100

Abstract

   In recent years, the number of liver transplantations has increased significantly, which determines the urgency of the problem of studying graft dysfunction. A small number of papers have been published on the relationship between the course of ulcerative colitis (UC) and the return of primary sclerosing cholangitis (PSC) after liver transplantation (TP). The article presents a clinical case of the return of PSC after TP against the background of a wave-like course of UC. The clinical picture of the disease and the changes that were revealed during additional examination before and after liver transplantation were discussed.

About the Authors

A. T. Marinchuk
Rostov State Medical University
Russian Federation

Alexander T. Marinchuk, Cand. Sci. (Med.), Associate Professor

Department of In-ternal Diseases No. 1

Rostov-on-Don



R. V. Korobka
Rostov State Medical University; Rostov Regional Clinical Hospital
Russian Federation

Roman V. Korobka, Cand. Sci. (Med.), Associate Professor, Director of the Center

Department of Recon-structive, Cardiovascular, Thoracic, Maxillofacial Surgery and Organ Transplantation;  Regional Center of Surgery and Donor Coordination

Rostov-on-Don



E. S. Pak
Rostov State Medical University; Rostov Regional Clinical Hospital
Russian Federation

Ekaterina S. Pak, Cand. Sci. (Med.), Assistant, Head of the Department

Department of Reconstructive, Car-diovascular, Thoracic, Maxillofacial Surgery
and Organ Transplantation; Regional Center of Surgery and Donor Coordination; Gastroenterology Department 

Rostov-on-Don



A. S. Khar’kov
Rostov State Medical University
Russian Federation

Alexander S. Kharkov, Cand. Sci. (Med.), Associate Professor

Department of In-ternal Diseases No. 1

Rostov-on-Don



References

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2. Voskanyan S.E., Syutkin V.E., Sushkov A.I., Voskanyan Yu.V., Veselkova A.Yu. Liver allograft pathology in the late post-transplant period. Transplantologiya. The Russian Journal of Transplantation. 2023;15(3):359-375. (In Russ.) DOI: 10.23873/2074-0506-2023-15-3-359-375

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4. Nikitin A.V., Khavkin A.I., Skvortsova T.A., Volynets G.V., Atameeva A.O. Combination of ulcerative colitis with cirrhosis of the liver in the outcome of primary sclerosing cholangitis. Experimental and Clinical Gastroenterology. 2020;174(5):104-107. (In Russ.) DOI: 10.31146/1682-8658-ecg-177-5-104-107

5. Podstavkina I.S., Mordasova V.I., Korotkikh N.N., Trunova P.A., Timchenko I.V., Dobrosotskikh G.V., et al. The effect of liver transplantation on the course of ulcerative colitis in patients with primary sclerosing cholangitis - ulcerative colitis on clinical examples. Pharmacology & Pharmacotherapy. 2023;(2):26-36. (In Russ.) DOI 10.46393/27132129_2023_2_26


Review

For citations:


Marinchuk A.T., Korobka R.V., Pak E.S., Khar’kov A.S. Recurrence of primary sclerosing cholangitis after liver transplantation, occurring on the background of ulcerative colitis. South Russian Journal of Therapeutic Practice. 2025;6(1):95-100. (In Russ.) https://doi.org/10.21886/2712-8156-2025-6-1-95-100

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ISSN 2712-8156 (Print)