Association of the PTPN22 Gene rs2476601 (C1858T) Polymorphism with Seronegative Spondyloarthritis
V. S. Mordovskii,
S. Yu. Nikulina,
A. A. Chernova,
E. V. Kapustina,
N. V. Aksyutina,
A. A. Lobastova https://doi.org/10.21886/2712-8156-2026-7-1-55-61
Abstract
Objective: to investigate the association of the single nucleotide polymorphism (SNP) rs2476601 (C1858T) of the *PTPN22* gene with seronegative spondyloarthritis (SpA) in a European-descent population of patients from the Krasnoyarsk region.
Materials and methods: the study included 216 patients of European descent from the Krasnoyarsk Territory diagnosed with SpA according to the Amor criteria for spondyloarthritis. Genotyping of the *PTPN22* gene SNP rs2476601 was performed.
Results: the study confirmed an association between the CT genotype of the *PTPN22* gene SNP rs2476601 and SpA in the European-descent population of the Krasnoyarsk Territory. The CC genotype was statistically significantly more prevalent in the control group and is likely to have a protective effect.
Conclusion: the study showed an association between the CT genotype of the rs2476601 SNP of the PTPN22 gene and CSpA in the European population of the Krasnoyarsk Territory. Further research will improve the understanding of the role of CSpA in the pathogenesis.
About the Authors
V. S. Mordovskii
Krasnoyarsk State Medical University n. a. prof. V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Vitiliy S. Mordovskii, Assistant Professor, Department of Internal Medicine
Krasnoyarsk
S. Yu. Nikulina
Krasnoyarsk State Medical University n. a. prof. V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Svetlana Yu. Nikulina, Dr. Sci, (Med.), Prof., Head of the Department of Internal Medicine, MD, PhD
Krasnoyarsk
A. A. Chernova
Krasnoyarsk State Medical University n. a. prof. V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Anna A. Chernova, Dr. Sci, (Med.), Professor, Department of Internal Medicine, MD, PhD
Krasnoyarsk
E. V. Kapustina
Krasnoyarsk State Medical University n. a. prof. V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Ekaterina V. Kapustina, Cand. Sci, (Med.), , Associate Professor, Department of Propaedeutics of Internal Diseases and Therapy with a Postgraduate Course
Krasnoyarsk
N. V. Aksyutina
Krasnoyarsk State Medical University n. a. prof. V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Natalya V. Aksyutina, Dr. Sci, (Med.), Professor, Department of Internal Medicine, MD, PhD.
Krasnoyarsk
A. A. Lobastova
Krasnoyarsk State Medical University n. a. prof. V.F. Voyno-Yasenetsky
Russian Federation
Russian Federation
Anastasia A. Lobastova, Postgraduate Student, Department of Internal Medicine
Krasnoyarsk
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Review
For citations:
Mordovskii V.S., Nikulina S.Yu., Chernova A.A., Kapustina E.V., Aksyutina N.V., Lobastova A.A. Association of the PTPN22 Gene rs2476601 (C1858T) Polymorphism with Seronegative Spondyloarthritis. South Russian Journal of Therapeutic Practice. 2026;7(1):55-61. (In Russ.) https://doi.org/10.21886/2712-8156-2026-7-1-55-61
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