A Case of Successful Cardiac Surgery in a Patient with Undiagnosed Acromegaly. South Russian Journal of Therapeutic Practice
https://doi.org/10.21886/2712-8156-2026-7-1-106-113
Abstract
Acromegaly is a severe, chronic neuroendocrine disorder, most commonly occurring in adults, characterized by excess growth hormone (GH) and subsequent elevated insulin-like growth factor-1 (IGF-1) levels. Cardiovascular complications are considered the most common complications in patients with acromegaly, negatively impacting quality of life and prognosis. This article presents a case of aneurysmal aortic dilation with severe aortic regurgitation in a patient with acromegaly. The patient underwent a successful Bentall procedure (aortic and aortic valve replacement), and 6 months after cardiac surgery, transsphenoidal adenomectomy was performed without complications.
About the Authors
Z. G. TatarintsevaRussian Federation
Zoya G. Tatarintseva, Cand. Sci. (Med.), Head of the Department of Cardiology; Assistant of the Department of Cardiac Surgery and Cardiology of the Faculty of Advanced Training and Professional Retraining of Specialists
Krasnodar
Yu. A. Katushkina
Russian Federation
Yuliya A. Katushkina, endocrinologist of the endocrinology department; Assistant of the Department of Therapy No. 1 of the Faculty of Advanced Training and Professional Retraining of Specialists
Krasnodar
G. A. Golovina
Russian Federation
Galina A. Golovina, Cand. Sci. (Med.), cardiologist, assistant of the Department of Cardiac Surgery and Cardiology
Krasnodar
E. D. Kosmacheva
Russian Federation
Elena D. Kosmacheva, Dr. Cand. Sci. (Med.), Professor, Deputy Chief Physician for the Medical Department; Head of the Department of Therapy No. 1 of the Faculty of Education and Training
Krasnodar
References
1. Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, et al. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020;21(4):667-678. DOI: 10.1007/s11154-020-09588-z
2. Gadelha MR, Kasuki L, Lim DST, Fleseriu M. Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update. Endocr Rev. 2019;40(1):268-332. DOI: 10.1210/er.2018-00115
3. Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, et al. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933-3951. DOI: 10.1210/jc.2014-2700
4. Burton T, Le Nestour E, Neary M, Ludlam WH. Incidence and prevalence of acromegaly in a large US health plan database. Pituitary. 2016;19(3):262-267. DOI: 10.1007/s11102-015-0701-2
5. Pivonello R, Auriemma RS, Grasso LF, Pivonello C, Simeoli C, Patalano R, et al. Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities. Pituitary. 2017;20(1):46-62. DOI: 10.1007/s11102-017-0797-7
6. Yang H, Tan H, Huang H, Li J. Advances in Research on the Cardiovascular Complications of Acromegaly. Front Oncol. 2021;11:640999. DOI: 10.3389/fonc.2021.640999
7. Wu JC, Huang WC, Chang HK, Ko CC, Lirng JF, Chen YC. Natural History of Acromegaly: Incidences, Re-operations, Cancers, and Mortality Rates in a National Cohort. Neuroendocrinology. 2020;110(11-12):977-987. DOI: 10.1159/000505332
8. Ramos-Leví AM, Marazuela M. Bringing Cardiovascular Comorbidities in Acromegaly to an Update. How Should We Diagnose and Manage Them? Front Endocrinol (Lausanne). 2019;10:120. DOI: 10.3389/fendo.2019.00120
9. Sharma MD, Nguyen AV, Brown S, Robbins RJ. Cardiovascular Disease in Acromegaly. Methodist Debakey Cardiovasc J. 2017;13(2):64-67. DOI: 10.14797/mdcj-13-2-64
10. Mosca S, Paolillo S, Colao A, Bossone E, Cittadini A, Iudice FL, et al. Cardiovascular involvement in patients affected by acromegaly: an appraisal. Int J Cardiol. 2013;167(5):1712-1718. DOI: 10.1016/j.ijcard.2012.11.109
11. Gharoy H, Taghavi S, Ghaemmaghami Z, Rabiei P, Afzalnia A. Aneurysmal dilation of sinus of Valsalva in a patient with undiagnosed acromegaly. Clin Case Rep. 2023;11(12):e8326. DOI: 10.1002/ccr3.8326
12. Belaya Zh.E., Golounina O.O., Rozhinskaya L.Y., Melnichenko G.A., Isakov M.А., Lutsenko A.S., et al. Epidemiology, clinical manifestations and efficiency of different methods of treatment of acromegaly according to the United Russian Registry of Patients with Pituitary Tumors. Problems of Endocrinology. 2020;66(1):93-103. (In Russ.) DOI: 10.14341/probl10333
13. Faje AT, Barkan AL. Basal, but not pulsatile, growth hormone secretion determines the ambient circulating levels of insulin-like growth factor-I. J Clin Endocrinol Metab. 2010;95(5):2486-2491. DOI: 10.1210/jc.2009-2634
14. Giustina A, Chanson P, Kleinberg D, Bronstein MD, Clemmons DR, Klibanski A, et al. Expert consensus document: A consensus on the medical treatment of acromegaly. Nat Rev Endocrinol. 2014;10(4):243-248. DOI: 10.1038/nrendo.2014.21
15. Famini P, Maya MM, Melmed S. Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients. J Clin Endocrinol Metab. 2011;96(6):1633-1641. DOI: 10.1210/jc.2011-0168
16. Lavrentaki A, Paluzzi A, Wass JA, Karavitaki N. Epidemiology of acromegaly: review of population studies. Pituitary. 2017;20(1):4-9. DOI: 10.1007/s11102-016-0754-x
17. Yang C, Li G, Jiang S, Bao X, Wang R. Preoperative Somatostatin Analogues in Patients with Newly-diagnosed Acromegaly: A Systematic Review and Meta-analysis of Comparative Studies. Sci Rep. 2019;9(1):14070. DOI: 10.1038/s41598-019-50639-6
18. Albarel F, Cuny T, Graillon T, Dufour H, Brue T, Castinetti F. Preoperative Medical Treatment for Patients With Acromegaly: Yes or No? J Endocr Soc. 2022;6(9):bvac114. DOI: 10.1210/jendso/bvac114
Review
For citations:
Tatarintseva Z.G., Katushkina Yu.A., Golovina G.A., Kosmacheva E.D. A Case of Successful Cardiac Surgery in a Patient with Undiagnosed Acromegaly. South Russian Journal of Therapeutic Practice. South Russian Journal of Therapeutic Practice. 2026;7(1):106-113. (In Russ.) https://doi.org/10.21886/2712-8156-2026-7-1-106-113
JATS XML


















