The experience of successful use of melatonin, L‑arginine and L‑carnitine in treatment post-COVID‑19 pain syndromes in persons with cystic transformation of the pineal gland
https://doi.org/10.21886/2712-8156-2021-2-4-101-104
Abstract
As an introduction, the article presents a small review of the literature devoted to the problem of clinical variants of postovoid syndrome and, in particular, headaches and back pain. There are 6 cases with various headaches and 1 case with back pain in patients with cystic transformation of the pineal gland after a verified COVID-19 infection. All patients were diagnosed with melatonin, L‑arginine and L‑carnitine deficiency before treatment. After the replacement therapy, the pain syndrome was stopped in all patients within 10 days, and a month after the start of treatment, the indicators of melatonin, L‑arginine and l‑carnitine returned to the reference values of the norm.
About the Authors
E. V. Baliazina
Rostov State Medical University
Russian Federation
Russian Federation
Elena V. Balyazina, Dr. Sci. (Med.), Associate Professor, Professor of the Department of Neurology and Neurosurgery
Rostov-on-Don
A. Y. Stepanova
Rostov State Medical University
Russian Federation
Russian Federation
Anastasia Y. Stepanova, resident of the Department of Neurology and Neurosurgery
Rostov-on-Don
V. A. Baliazin
Rostov State Medical University
Russian Federation
Russian Federation
Viktor A. Balyazin, Dr. Sci. (Med.), Professor, Head of the Department of Neurology and Neurosurgery
Rostov-on-Don
References
1. Crook H, Raza S, Nowell J, Young M, Edison P. Long covidmechanisms, risk factors, and management. BMJ. 2021;374: n1648. DOI: 10.1136/bmj.n1648. Erratum in: BMJ. 2021;374: n1944. PMID: 34312178.
2. Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis (Lond). 2021:1–18. DOI: 10.1080/23744235.2021.1924397
3. Pavli A, Theodoridou M, Maltezou HC. Post-COVID Syndrome: Incidence, Clinical Spectrum, and Challenges for Primary Healthcare Professionals. Arch Med Res. 2021;52 (6):575–581. DOI: 10.1016/j.arcmed.2021.03.010
4. Fernández-de-Las-Peñas C, Navarro-Santana M, Gómez- Mayordomo V, Cuadrado ML, García-Azorín D, arendtnielsen L, et al. Headache as an acute and post-COVID-19 symptom in COVID-19 survivors: A meta-analysis of the current literature. Eur J Neurol. 2021;28 (11):3820–3825. DOI: 10.1111/ene.15040.
5. Белопасов В. В., Журавлева Е. Н., Нугманова Н. П., Абдрашитова А. Т. Постковидные неврологические синдромы. Клиническая практика. 2021;12 (2):69–82. DOI: 10.17816/clinpract71137
6. Боголепова А.Н, Осиновская Н.А, Коваленко Е.А, Махнович Е. В. Возможные подходы к терапии астенических и когнитивных нарушений при постковидном синдроме. Неврология, нейропсихиатрия, психосоматика. 2021;13 (4):88–93. DOI: 10.14412/2074-2711-2021-488–93
7. Fraser DD, Slessarev M, Martin CM, Daley M, Patel MA, Miller MR, et al. Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers. Crit Care Explor. 2020;2 (10): e0272. DOI: 10.1097/CCE.0000000000000272.
8. Shen B, Yi X, Sun Y, Bi X, Du J, Zhang C, et al Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Cell. 2020;182 (1):59–72.e15. DOI: 10.1016/j.Cell.2020.05.032.
9. Reizine F, Lesouhaitier M, Gregoire M, Pinceaux K, Gacouin A, Maamar A, et al. SARS-cov-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage. J Clin Immunol. 2021;41 (3):515–525. DOI: 10.1007/s10875-020-00920-5.
10. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, et al. Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute sarscov-2 Infection and Inflammatory Cytokine Responses. J Proteome Res. 2021;20 (5):2796–2811. DOI: 10.1021/acs.Jproteome.1c00052.
11. Bellamine A, Pham TNQ, Jain J, Wilson J, Sahin K, Dallaire F, et al. L–Carnitine Tartrate Downregulates the ACE2 Receptor and Limits SARS-cov-2 Infection. Nutrients. 2021;13 (4):1297. DOI: 10.3390/nu13041297.
12. Zhang R, Wang X, Ni L, Di X, Ma B, Niu S, et al. COVID-19: Melatonin as a potential adjuvant treatment. Life Sci. 2020;250:117583. DOI: 10.1016/j.lfs.2020.117583.
13. Reiter RJ, Abreu-Gonzalez P, Marik PE, dominguezrodriguez A. Therapeutic Algorithm for Use of Melatonin in Patients With COVID-19. Front Med (Lausanne). 2020;7:226. DOI: 10.3389/fmed.2020.00226.
Review
For citations:
Baliazina E.V., Stepanova A.Y., Baliazin V.A. The experience of successful use of melatonin, L‑arginine and L‑carnitine in treatment post-COVID‑19 pain syndromes in persons with cystic transformation of the pineal gland. South Russian Journal of Therapeutic Practice. 2021;2(4):101-104. (In Russ.) https://doi.org/10.21886/2712-8156-2021-2-4-101-104
Views:
4037
Email this article 