Secondary arterial hypertension and endogenous hypercortisolism in general medical practice

Abstract

Arterial hypertension (AH) is a widespread syndrome in clinical practice. In most cases, the blood pressure increase is essential (primary) in nature. Meanwhile, many clinical situations require exclusion of secondary AH due medications and other substances, renal, endocrine, cardiovascular, neurological pathology. A special place in the structure of the endocrine AH is engaged in pathology caused by excessive production of cortisol. Despite its heterogeneous origin, endogenous hype rcortisolism (EH) has a certain similarity in clinical manifestations. The article describes two clinical cases of AH in 32-year-old women with different pathogenetic variants of endogenous hypercortisolism (EH). The presented medical histories are the basis for the discussion of features of the clinical and laboratory manifestations of EH, principles of the differential diagnos is and modern approaches to treatment. The aim of this publication is to draw attention of doctors of various specialties to early detection of EH, the timely elimination of which significantly improves the quality and increases the life expectancy of patients.