A difficult to diagnose case of respiratory tract injury in granulomatosis with polyangiitis
https://doi.org/10.21886/2712-8156-2023-4-3-87-93
Abstract
Granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) is a rare autoimmune disease, characterized by vasculitis of small and medium-sized vessels, as well as the formation of granulomas and the most frequent involvement of the upper respiratory tract, lungs, kidneys and eyes in the pathological process. In the absence of treatment, the disease progresses rapidly and is fatal. The onset of the disease is possible at any age. Pharmacotherapy is aimed at suppressing the immunopathological reactions underlying the disease in order to achieve complete remission associated with anti-neutrophil cytoplasmic antibodies of systemic vasculitis (ANCA-SV). The article deals with a difficult case for diagnosis of respiratory tract damage in GPA in a 60-year-old woman.
About the Authors
V. A. Nevzorova
Pacific State Medical University
Russian Federation
Russian Federation
Nevzorova Vera A. - Dr. Sci. (Med.), Professor, Director of the Institute of therapy and instrumental diagnostics.
Vladivostok
N. V. Shestakova
Pacific State Medical University
Russian Federation
Russian Federation
Shestakova Natalya V. - Dr. Sci. (Med.), Associate Professor of the Institute of therapy and instrumental diagnostics.
Vladivostok
M. V. Mokshina
Pacific State Medical University
Russian Federation
Russian Federation
Mokshina Margarita V. - Dr. Sci. (Med.), Associate Professor, аssociate of the Institute of therapy and instrumental diagnostics.
Vladivostok
E. V. Samoilenko
Vladivostok Clinical Hospital №1
Russian Federation
Russian Federation
Samoylenko Elena V. - head of the pulmonology department.
Vladivostok
A. V. Chernyshenko
Vladivostok Clinical Hospital №1
Russian Federation
Russian Federation
Chernyshenko Aleksandr V. - radiologist, head of the Center of radiation diagnostics.
Vladivostok
References
1. Лаушкина Ж.А., Пушкарева Е.Ю., Медведев С.А., Филимонов П.Н., Ягубкин П.А. Гранулематоз с полиангиитом (Вегенера): клинический случай гипердиагностики туберкулеза легких. Пульмонология. 2022; 32 (1): 130–136. DOI: 10.18093/0869-0189-2022-32-1-130-136.
2. Akiyama M, Zeisbrich M, Ibrahim N, Ohtsuki S, Berry GJ, Hwang PH, et al. Neutrophil Extracellular Traps Induce Tissue-Invasive Monocytes in Granulomatosis With Polyangiitis. Front Immunol. 2019;10:2617. DOI: 10.3389/fimmu.2019.02617.
3. Серебрякова Е.Н., Волосников Д.К., Пищальников А.Ю., Глазырина Г.А., Сударева О.О., Негденова О.С. Гранулематоз Вегенера (гранулематоз с полиангиитом). Трудный пациент. 2021;19(4):39–44. DOI: 10.224412/2074-1005-2021-4-39-44.
4. Бабаева А.Р., Калинина Е.В., Звоноренко М.С. Трудности диагностики гранулематоза Вегенера у взрослых в современной клинической практике (клиническое наблюдение). Волгоградский научно-медицинский журнал. 2016;3(51):49–54. eLIBRARY ID: 27249184 EDN: UQRGZV
5. Черняев А.Л., Березовский Ю.С., Войтковская К.С., Михалева Л.М., Самсонова М.В. Диагностика гранулематоза Вегенера у пациента 14 лет. Архив патологии. 2013;75(3):40‐47. eLIBRARY ID: 19093381 EDN: QBVIMB
6. Войцеховский В.В., Погребная М.В., Гоборов Н.Д., Фомина О.П., Горячева С.А. Клиническое наблюдение пациентки с гранулематозом Вегенера. Бюллетень физиологии и патологии дыхания. 2017;1(66):89–97. DOI: 10.12737/article_5a24d1a5e1f301.09080009.
Supplementary files
Review
For citations:
Nevzorova V.A., Shestakova N.V., Mokshina M.V., Samoilenko E.V., Chernyshenko A.V. A difficult to diagnose case of respiratory tract injury in granulomatosis with polyangiitis. South Russian Journal of Therapeutic Practice. 2023;4(3):87-93. (In Russ.) https://doi.org/10.21886/2712-8156-2023-4-3-87-93
Views:
3087
Email this article 