Syntropy of bronchial asthma and gastroesophageal reflux disease: pathogenetic features and possibilities of minimally invasive diagnostics at the outpatient stage
https://doi.org/10.21886/2712-8156-2023-4-2-25-34
Abstract
The review highlights the prevalence, pathogenesis and clinical manifestations of bronchial asthma (BA), comorbid with gastroesophageal reflux disease (GERD). Difficulties in diagnosing triggers of extraesophageal symptoms were noted. Based on a large number of clinical studies, the review assesses the possibilities of minimally invasive methods for detecting biomarkers of gastroesophageal reflux (GER) and duodenogastroesophageal reflux (DGER) in the oral fluid. With syntropy of GERD and BA, a significant role and relationship between the parameters of respiratory oxidative inflammation and impaired functions of external respiration was noted. To confirm the reflux origin of extraesophageal respiratory symptoms, it is important to use minimally invasive methods for detecting bilirubin and pepsin in the oral fluid, and to assess the activity of respiratory stress, the determination of its substrates in the blood. Further studies aimed at determining the normative concentrations of DGER substrates in the oral fluid and markers of oxidative respiratory inflammation in the blood will help improve the diagnosis and treatment of BA and GERD syntropy in outpatient practice.
About the Authors
V. V. Gorban
Kuban State Medical University
Russian Federation
Russian Federation
Vitaly V. Gorban - Dr. Sci. (Med.), Head of the chair of polyclinic therapy with course of general medical practice (family medicine) FPK and PPS, Kuban State Medical University.
Krasnodar
I. V. Kovrigina
Kuban State Medical University
Russian Federation
Russian Federation
Irina V. Kovrigina - Cand. Sci. (Med.), assistant of the Department polyclinic therapy with course of general medical practice (family medicine) FPK and PPS., Kuban State Medical University.
Krasnodar
E. V. Gorban
Kuban State Medical University
Russian Federation
Russian Federation
Еlena V. Gorban - Cand. Sci. (Med.), assistant of the Department polyclinic therapy with course of general medical practice (family medicine) FPK and PPS., Kuban State Medical University.
Krasnodar
E. S. Kameneva
Kuban State Medical University
Russian Federation
Russian Federation
Еlena S. Kameneva - Cand. Sci. (Med.),аssistant of the Department polyclinic therapy with course of general medical practice (family medicine) FPK and PPS, Kuban State Medical University.
Krasnodar
O. V. Svistun
Kuban State Medical University
Russian Federation
Russian Federation
Olesya V. Svistun - Assistant of the Department polyclinic therapy with course of general medical practice (family medicine) FPK and PPS, Kuban State Medical University.
Krasnodar
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Gorban V.V., Kovrigina I.V., Gorban E.V., Kameneva E.S., Svistun O.V. Syntropy of bronchial asthma and gastroesophageal reflux disease: pathogenetic features and possibilities of minimally invasive diagnostics at the outpatient stage. South Russian Journal of Therapeutic Practice. 2023;4(2):25-34. (In Russ.) https://doi.org/10.21886/2712-8156-2023-4-2-25-34
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