Study of Angiogenesis Factors in Patients with Acute Myocardial Infarction

Abstract

Objective: to study the level of angiogenesis factors (fibroblast growth factor, platelet growth factor, endostatin), as well as tumor necrosis factor alpha in the acute period of myocardial infarction 6 months after the event, depending on the presence of drug revascularization.

Materials and methods: patients with AMI of the anterior wall of the left ventricle with St segment elevation were Included. AMI patients were divided into groups: I group included patients who received thrombolytic therapy (TLT), II - patients who did not receive TLT. Group III was composed of relatively healthy volunteers. Angiogenesis indicators were studied depending on the TIMI scale and complications at the hospital and outpatient stages of treatment.

Results: In AMI patients, an increase in angiogenesis processes was detected, regardless of the presence or absence of thrombolytic therapy, and an increase in the level of angiogenesis inducers. Six months after the activity of angiogenesis processes is maintained, while inflammation decreases − a decrease in the tumor necrosis factor alpha.

Conclusions: In patients with AMI with ST segment rise in the acute period, there is an increase in angiogenesis processes, regardless of the presence or absence of TLT.