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Leading predictors of early and late hospital mortality among patients with acute decompensated heart failure and ways to improve prognosis

https://doi.org/10.21886/2712-8156-2021-2-1-40-49

Abstract

Objective: to analyze the leading causes of early (first two days) and late (after the second day) hospital mortality among of patients with acute decompensated heart failure.

Materials and methods: a retrospective single-center cohort (n=718) of patients with acute decompensated heart failure.

Results: predictors of prognosis for early hospital mortality were pulmonary edema, hepatomegaly, the need for inotropic and vasopressive drugs, the level of systolic blood pressure and creatinine. Predictors of prognosis for late hospital mortality were pulmonary edema, the need for inotropic drugs, community-acquired pneumonia, and laboratory markers of acute renal injury.

Conclusion: Tactical approaches are proposed to reduce hospital mortality of patients with acute decompensated heart failure.

About the Authors

D. S. Polyakov
Privolzhsky Research Medical University
Russian Federation

Dmitry S. Polyakov, Cand. Sci. (Med.), Associate Professor, Department of Therapy and Cardiology.

Nizhny Novgorod



I. V. Fomin
Privolzhsky Research Medical University
Russian Federation

Igor V. Fomin, Dr. Sci. (Med.), Associate Professor, Head of the V.G. Vogralika Department of Hospital Therapy and General Medical Practice.

Nizhny Novgorod



N. G. Vinogradova
Privolzhsky Research Medical University
Russian Federation

Nadezhda G. Vinogradova, Cand. Sci. (Med.), Associate Professor, Department of Therapy and Cardiology.

Nizhny Novgorod



Yu. V. Badin
Privolzhsky Research Medical University
Russian Federation

Yuri V. Badin, Cand. Sci. (Med.), Associate Professor, Department of Therapy and Cardiology.

Nizhny Novgorod



E. V. Shcherbinina
Privolzhsky Research Medical University
Russian Federation

Elena V. Shcherbinina, Cand. Sci. (Med.), Associate Professor, Department of Therapy and Cardiology.

Nizhny Novgorod



А. R. Vaisberg
Privolzhsky Research Medical University
Russian Federation

Alexandra R. Vaisberg, Cand. Sci. (Med.), Associate Professor, Department of Therapy and Cardiology.

Nizhny Novgorod



References

1. Chun S, Tu JV, Wijeysundera HC, Austin PC, Wang X, Levy D, et al. Lifetime analysis of hospitalizations and survival of patients newlyadmittedwithheartfailure.orrHeartFa/7.2012;5(4):414-21. doi: 10.1161/CIRCHEARTFAILURE.111.964791

2. Cowie MR, Anker SD, Cleland JGF, Felker GM, Filippatos G, Jaarsma T, et al. Improving care for patients with acute heart failure: before, during and after hospitalization. ESC Heart Fai7. 2014;1(2):110-145. doi: 10.1002/ehf2.12021.

3. Ezekowitz JA, Kaul P, Bakal JA, Armstrong PW, Welsh RC, McAlister FA. Declining in-hospital mortality and increasing heart failure incidence in elderly patients with first myocardial infarction. J Am Co77 Cardio7. 2009;53(1):13-20. doi: 10.1016/j.jacc.2008.08.067

4. Поляков Д.С., Фомин И.В., Валикулова Ф.Ю., Вайсберг А.Р., Краием Н., Бадин Ю.В. и др. Эпидемиологическая программа ЭПОХА-ХСН: декомпенсация сердечной недостаточности в реальной клинической практике (ЭПОХА-Д-ХСН). Журнал Сердечная Недостаточность. 2016;17(6):299-305. eLIBRARY ID: 27714432

5. Российское Диализное Общество. Клинические практические рекомендации KDIGO по острому почечному повреждению. Нефрология И Диализ. 2014;16(4):1-155. eLIBRARY ID: 23330010

6. Ambrosy AP, Vaduganathan M, Huffman MD, Khan S, Kwasny MJ, Fought AJ, et al. Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial. Eur J Heart Fai7. 2012;14(3):302-11. doi: 10.1093/eurjhf/hfs007

7. Nikolaou M, Parissis J, Yilmaz MB, Seronde MF, Kivikko M, Laribi S, et al. Liver function abnormalities, clinical profile, and outcome in acute decompensated heart failure. Eur Heart J. 2013;34(10):742-9. doi: 10.1093/eurheartj/ehs332

8. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Devel-oped with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129-2200. doi: 10.1093/eurheartj/ehw128

9. Bistola V, Arfaras-Melainis A, Polyzogopoulou E, Ikonomidis I, Parissis J. Inotropes in Acute Heart Failure: From Guidelines to Practical Use: Therapeutic Options and Clinical Practice. Card Fai7 Rev. 2019;5(3):133-139. doi: 10.15420/cfr.2019.11.2

10. Rafouli-Stergiou P, Parissis JT, Anastasiou-Nana M. Inotropes for the management of acute heart failure patients with renal dysfunction. Still an option? Expert Opin Pharmacother. 2012;13(18):2637-47. doi: 10.1517/14656566.2012.749859

11. Curfman G. Vasodilator Therapy in Acute Heart Failure. JAMA. 2019;322(23):2288-2289. doi: 10.1001/jama.2019.20285

12. Holt DB Jr, Pang PS. Vasodilator Therapies in the Treatment of Acute Heart Failure. Curr Heart Fai7 Rep. 2019;16(1):32-37. doi: 10.1007/s11897-019-0421-4.

13. Peacock WF, Emerman C, Costanzo MR, Diercks DB, Lopatin M, Fonarow GC. Early vasoactive drugs improve heart failure outcomes. Congest Heart Fai7. 2009;15(6):256-64. doi: 10.1111/j.1751-7133.2009.00112.x.

14. Setoguchi S, Stevenson LW, Schneeweiss S. Repeated hospitalizations predict mortality in the community population with heart failure. Am Heart J. 2007;154(2):260-6. doi: 10.1016/j.ahj.2007.01.041

15. Desai AS, Claggett BL, Packer M, Zile MR, Rouleau JL, Swed-berg K, et al. Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization. J Am Co77 Cardio7. 2016;68(3):241-248. doi: 10.1016/j.jacc.2016.04.047.

16. Alghalayini KW. Effect of diuretic infusion clinic in preventing hospitalization for patients with decompensating heart 1 Российское респираторное общество, Межрегиональная ассоциация по клинической микробиологии и антимикробной химиотерапии. Внебольничная пневмония у взрослых. Клинические рекомендации.; 2019. failure. SAGE Open Med. 2020;8:2050312120940094. doi: 10.1177/2050312120940094.

17. Buckley LF, Carter DM, Matta L, Cheng JW, Stevens C, Belen-kiy RM, et al. Intravenous Diuretic Therapy for the Management of Heart Failure and Volume Overload in a Multidisciplinary Outpatient Unit. JACC Heart Fail. 2016;4(1):1-8. doi: 10.1016/j.jchf.2015.06.017

18. Виноградова Н.Г., Поляков Д.С., Фомин И.В. Риски повторной госпитализации пациентов с ХСН при длительном наблюдении в специализированном центре лечения ХСН и в реальной клинической практике. Кардиология. 2020;60(3):59-69. Doi: 10.18087/cardio.2020.3.n1002

19. Фомин И.В., Виноградова Н.Г. Организация специализированной медицинской помощи больным с хронической сердечной недостаточностью. Кардиосоматика. 2017;8(3):10-15. doi: 10.26442/2221-7185_8.3.10-15

20. Holgado JL, Lopez C, Fernandez A, Sauri I, Uso R, Trillo JL, et al. Acute kidney injury in heart failure: a population study. ESC Heart Fail. 2020;7(2):415-422. doi: 10.1002/ehf2.12595

21. Shirakabe A, Hata N, Kobayashi N, Shinada T, Tomita K, Tsu-rumi M, et al. Prognostic impact of acute kidney injury in patients with acute decompensated heart failure. Circ J. 2013;77(3):687-96. doi: 10.1253/circj.cj-12-0994

22. Romero-Gonzalez G, Ravassa S, Gonzalez O, Lorenzo I, Rojas MA, Garcia-Trigo I, et al. Burden and challenges of heart failure in patients with chronic kidney disease. A call to action. Nefrologia. 2020;40(3):223-236. doi: 10.1016/j.ne-fro.2019.10.005.

23. Menne J, Dumann E, Haller H, Schmidt BMW. Acute kidney injury and adverse renal events in patients receiving SGLT2-inhibitors: A systematic review and meta-analysis. PLoS Med. 2019;16(12):e1002983. doi: 10.1371/journal.pmed.1002983

24. Арутюнов А.Г., Драгунов Д.О., Арутюнов Г.П., Рылова А.К., Пашкевич Д.Д., Витер К.В., и др. Первое открытое исследование синдрома острой декомпенсации сердечной недостаточности и сопутствующих заболеваний в Российской Федерации. Независимый регистр ОРАКУЛ-РФ. Кардиология. 2015;55(5):12-21. eLIBRARY ID: 23756615

25. Bonten MJ, Huijts SM, Bolkenbaas M, Webber C, Patterson S, Gault S, et al. Polysaccharide conjugate vaccine against pneumococcal pneumonia in adults. N Engl J Med. 2015;372(12):1114-25. doi: 10.1056/NEJMoa1408544

26. Мареев В.Ю., Фомин И.В., Агеев Ф.Т., Беграмбекова Ю.Л., Васюк Ю.А., Гарганеева А.А., и др. Клинические рекомендации ОССН - РКО - РНМОТ. Сердечная недостаточность: хроническая (ХСН) и острая декомпенсированная (ОДСН). Диагностика, профилактика и лечение. Кардиология. 2018;58(6S):8-158. Doi: 10.18087/cardio.2475


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For citations:


Polyakov D.S., Fomin I.V., Vinogradova N.G., Badin Yu.V., Shcherbinina E.V., Vaisberg А.R. Leading predictors of early and late hospital mortality among patients with acute decompensated heart failure and ways to improve prognosis. South Russian Journal of Therapeutic Practice. 2021;2(1):40-49. (In Russ.) https://doi.org/10.21886/2712-8156-2021-2-1-40-49

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