Analysis of survival and risk factors in recipients with coronary artery disease of a heart transplant
T. V. Stavenchuk,
E. D. Kosmachova,
I. A. Shelestova,
K. O. Barbuhatty,
M. V. Kolodina,
V. A. Porhanov https://doi.org/10.21886/2712-8156-2021-2-2-34-43
Abstract
Objective: to conduct a comparative analysis of survival rate and development of heart transplant coronary artery disease risk factors during early and late post-transplantation periods.
Materials and methods: a retrospective analysis of 58 patients with was conducted in S.V. Ochapovsky Region Clinical Hospital № 1, Krasnodar. Inclusion criteria were patients with vasculopathy; group № 1 — recipients with heart transplant coronary artery disease up until 3 years after heart transplantation; group № 1 — recipients with heart transplant coronary artery desease 3 years after heart transplantation. Endomyocardial biopsy, coronary angiography and immunological examination were used for monitoring heart recipients.
Results: survival rate in group № 1 — 51,9%; in group № 2 — 64,5%. During studying the influence of age category on survival rate it was discovered that belonging to the age category influences on the survival rate in group № 1, p – 0,023. Death risk in group №1 is 1,7 (0,59 – 4,85) times higher in comparison with group № 2. When combined heart transplant coronary artery desease with cellular and humoral rejection in group №1 death risk is reliably 2,75 (1,58 – 4,78) times higher (p = 0,010). The frequency of heart transplant coronary artery desease recurrence does not have a meaningful impact on the survival rate of the recipients with heart transplant coronary artery desease n both groups. One of the meaningful risk factors in two groups, which affects heart transplant coronary artery desease development is cytomegalovirus infection. Cellular rejection is also a fact which influences lethal outcome.
About the Authors
T. V. Stavenchuk
S.V. Ochapovsky Region Clinical Hospital № 1;Kuban State Medical University
Russian Federation
Russian Federation
Tatuana V. Stavenchuk, Cand. Sci. (Med.), assistant of therapy department №1 FQI and PST; doctor of ultrasonic diagnostics
Krasnodar
E. D. Kosmachova
S.V. Ochapovsky Region Clinical Hospital № 1;Kuban State Medical University
Russian Federation
Russian Federation
Elena D. Kosmachova, Dr. Sci. (Med.), professor, Chief of Chair Therapy department №1 FQI and PST
Krasnodar
I. A. Shelestova
S.V. Ochapovsky Region Clinical Hospital № 1;Kuban State Medical University
Russian Federation
Russian Federation
Inga A. Shelestova, Cand. Sci. (Med.), associate professor of department of cardiology and cardiosurgery FQI and PST; deputy chief physician
Krasnodar
K. O. Barbuhatty
S.V. Ochapovsky Region Clinical Hospital № 1;Kuban State Medical University
Russian Federation
Russian Federation
Kirill O. Barbuhatty, Dr. Sci. (Med.), Professor;the head of the department, the chief of the department of cardiac surgery and cardiology FQI and PST; chief cardiac surgeon
Krasnodar
M. V. Kolodina
S.V. Ochapovsky Region Clinical Hospital № 1
Margarita V. Kolodina, Cand. Sci. (Med.), doctor of cardiology
Krasnodar
V. A. Porhanov
Kuban State Medical University
Russian Federation
Russian Federation
Vladimir A. Porhanov, Dr. Sci. (Med.), the thoracic head surgeon of Krasnodar region, the Member of European scientific organizations; the Associate Member of Russian Academy of Sciences; the head of the department of oncology with a course of thoracic surgery
Krasnodar
References
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Supplementary files
Review
For citations:
Stavenchuk T.V., Kosmachova E.D., Shelestova I.A., Barbuhatty K.O., Kolodina M.V., Porhanov V.A. Analysis of survival and risk factors in recipients with coronary artery disease of a heart transplant. South Russian Journal of Therapeutic Practice. 2021;2(2):34-43. (In Russ.) https://doi.org/10.21886/2712-8156-2021-2-2-34-43
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