Cardiometabolic profile in women after pregnancy hypertension: propency score matching

Оbjective: to assess the cardiometabolic profile and cardiovascular risk factors in women with a history of hypertension during pregnancy. Materials and methods: a case-control observational study based on a prospective cohort study included 66 women, divided into two groups: group 1 — with a history of hypertension during pregnancy (n=33), and group 2 (control) — with a history of normotensive pregnancy (n=33). We applied the propensity score -matching method. Results: women in group 1 women were more often had hypertension and obesity compared with the control group. The most significant changes in the cardiometabolic profile were found in group 1: the highest concentrations of glucose and immunoreactive insulin, glycated hemoglobin, uric acid, alanine aminotransferase, aspartate aminotransferase, C-reactive protein in serum, and HOMA-IR insulin resistance index. An increased left ventricular (LV) mass index and the urine albumin/ creatinine ratio were higher among women in group 1 compared with group 2. Conclusion: after applying the propensity score matching, the most significant differences were obtained in the frequency of hypertension, serum concentrations of alanine aminotransferase, C-reactive protein, and the frequency of elevated albumin/creatinine ratio.

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