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A clinical case of an ischemic heart disease with Werner Syndrome

https://doi.org/10.21886/2712-8156-2023-4-3-108-113

Abstract

Werner's syndrome is a disease characterized by premature aging, including the earlier development of diseases of the cardiovascular system: generalized atherosclerosis, hypertension, ischemic heart disease, and the occurrence of fatal complications such as myocardial infarction, stroke, at a younger age. It is cardiovascular diseases are the main cause of death of patients with Werner syndrome, whose life expectancy does not exceed 50 years. Therefore, patients with this syndrome need regular monitoring for early detection of signs of cardiovascular diseases, an increase in the quality and duration of life.

About the Authors

A. V. Khripun
Rostov State Medical University; Rostov Regional Clinical Hospital
Russian Federation

Khripun Alexey V. - Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases No. 1 of the RStMU, Chief Freelance Cardiologist of the Ministry of Health of the Rostov Region, Deputy Chief Physician for the Medical Department of the RRCH, Director of the Regional Vascular Center.

Rostov-on-Don



I. A. Bagaeva
Rostov Regional Clinical Hospital
Russian Federation

Bagaeva Inna A. - head of the cardiology department of the regional vascular center.

Rostov-on-Don



E. S. Godunko
Rostov State Medical University; Rostov Regional Clinical Hospital
Russian Federation

Godunko Elena S. - Cand. Sci. (Med.), Assistant of the Department of Internal Diseases No. 1 of the RStMU, cardiologist of the regional vascular center, RRCH.

Rostov-on-Don



O. V. Bukhtin
Rostov State Medical University
Russian Federation

Bukhtin Oleg V. - Resident of the Department of Internal Diseases No. 1.

Rostov-on-Don



A. A. Terentyev
Rostov State Medical University
Russian Federation

Terentyev Andrey A. - Resident of the Department of Cardiology, Rheumatology and Functional Diagnostics.

Rostov-on-Don



A. I. Chesnikova
Rostov State Medical University
Russian Federation

Chesnikova Anna I. - Dr. Sci. (Med.), Professor, Head of the Department of Internal Medicine No. 1, RStMU, chief freelance therapist of the Southern Federal District.

Rostov-on-Don



References

1. Oshima J, Sidorova JM, Monnat RJ Jr. Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions. Ageing Res Rev. 2017;33:105-114. DOI: 10.1016/j.arr.2016.03.002

2. Драпкина О.М., Шепель Р.Н. Теломеры и теломеразный комплекс. Основные клинические проявления генетического сбоя. Кардиоваскулярная терапия и профилактика. 2015;14(1):70-77. DOI: 10.15829/1728-8800-2015-1-70-77

3. Голоунина О.О., Фадеев В.В., Белая Ж.Е. Наследственные синдромы с признаками преждевременного старения. Остеопороз и остеопатии. 2019;22(3):4-18. DOI: 10.14341/osteo12331

4. Rincón A, Mora L, Suarez-Obando F, Rojas JA. Werner's Syndrome: Understanding the Phenotype of Premature Aging-First Case Described in Colombia. Case Rep Genet. 2019;2019:8538325. DOI: 10.1155/2019/8538325

5. Metwally S, El Ahwal L, Zaghlol K, Alwan N, Gabar R. Werner Syndrome: A Case Report of Two Brothers of Pangeria. Intern Med. 2019;9:308. DOI: 10.35248/2165-8048.19.9.308.

6. Tsuge K, Shimamoto A. Research on Werner Syndrome: Trends from Past to Present and Future Prospects. Genes (Basel). 2022;13(10):1802. doi: 10.3390/genes13101802

7. Chen L, Oshima J. Werner Syndrome. J Biomed Biotechnol. 2002;2(2):46-54. doi: 10.1155/S1110724302201011

8. Tokita M, Kennedy SR, Risques RA, Chun SG, Pritchard C, Oshima J, et al. Werner syndrome through the lens of tissue and tumour genomics. Sci Rep. 2016;6:32038. doi: 10.1038/srep32038


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For citations:


Khripun A.V., Bagaeva I.A., Godunko E.S., Bukhtin O.V., Terentyev A.A., Chesnikova A.I. A clinical case of an ischemic heart disease with Werner Syndrome. South Russian Journal of Therapeutic Practice. 2023;4(3):108-113. (In Russ.) https://doi.org/10.21886/2712-8156-2023-4-3-108-113

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ISSN 2712-8156 (Print)