Acute toxic hepatitis caused by ashwagandha consumption
https://doi.org/10.21886/2712-8156-2024-5-1-86-89
Abstract
Drug-induced liver damage is becoming one of the important liver diseases and a diagnostic problem for general practitioners and gastroenterologists. A case report of suspected liver damage caused by ashwagandha is described. The disease appeared 2 months after starting to take ashwagandha 1 g per day and occurred with cholestatic and cytolytic forms of liver damage, jaundice and skin itching. The therapy led to an improvement in the patient's general condition, but the jaundice tended to be protracted. It is recommended to avoid repeated use of dietary supplement (Ashwagandha).
About the Authors
A. T. MarinchukRussian Federation
Alexander T. Marinchuk — Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases No. 1
Rostov-on-Don
A. S. Kharkov
Russian Federation
Alexander S. Kharkov — Cand. Sci. (Med.), Associate Professor of the Department of Internal Diseases No. 1
Rostov-on-Don
O. E. Kolomatskaya
Russian Federation
Olga E. Kolomatskaya — Cand. Sci. (Med.), Associate Professor of the Department of Internal Medicine No. 1
Rostov-on-Don
M. A. Kashina
Russian Federation
Marina A. Kashina — gastroenterologist
Rostov-on-Don
References
1. Björnsson HK, Björnsson ES, Avula B, Khan IA, Jonasson JG, Ghabril M, Hayashi PH, Navarro V. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. Liver Int. 2020;40(4):825-829. DOI: 10.1111/liv.14393
2. Malík M, Tlustoš P. Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers. Plants (Basel). 2023;12(6):1364. DOI: 10.3390/plants12061364
3. Tóth M, Benedek AE, Longerich T, Seitz HK. Ashwagandha-induced acute liver injury: A case report. Clin Case Rep. 2023;11(3):e7078. DOI: 10.1002/ccr3.7078
4. Philips CA, Valsan A, Theruvath AH, Ravindran R, Oommen TT, Rajesh S, et al. Ashwagandha-induced liver injury-A case series from India and literature review. Hepatol Commun. 2023;7(10):e0270. DOI: 10.1097/HC9.0000000000000270
5. Lubarska M, Hałasiński P, Hryhorowicz S, Mahadea DS, Łykowska-Szuber L, Eder P, et al. Liver Dangers of Herbal Products: A Case Report of Ashwagandha-Induced Liver Injury. Int J Environ Res Public Health. 2023;20(5):3921. DOI: 10.3390/ijerph20053921
Supplementary files
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1. Withania somnifera - основные биологически активные соединения витанолиды и их химическая структура | |
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Type | Исследовательские инструменты | |
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For citations:
Marinchuk A.T., Kharkov A.S., Kolomatskaya O.E., Kashina M.A. Acute toxic hepatitis caused by ashwagandha consumption. South Russian Journal of Therapeutic Practice. 2024;5(1):86-89. (In Russ.) https://doi.org/10.21886/2712-8156-2024-5-1-86-89