Patients with coronary heart disease and chronic kidney disease - the possibility of applying cell adhesion molecule as a predictor of disease progression
https://doi.org/10.21886/2712-8156-2023-4-2-56-63
Abstract
Objective: to study the level of type 1 vascular endothelial adhesion molecule in patients with coronary heart disease depending on the stage of chronic kidney disease. Material and methods: the study included 115 patients, mean age was 67.56±12.42 years (63 men, 52 women) with ischemic heart disease (CAD), stable angina (tension), functional class 1–3, chronic kidney disease (CKD) C1–C3. The level of the vascular endothelial adhesion molecule type 1 (VCAM 1) was assessed using the enzyme immunoassay kit for the quantitative determination of human VCAM 1 ThermoFisher scientific. Results: in patients with CAD and CKD, the level of serum VCAM 1 progressively increases as angina pectoris worsens and can be regarded as an early marker of CAD progression. The level of VCAM 1 does not depend on the stage of CKD. When studying the correlation relationships between the level of serum VCAM 1 and clinical and laboratory data, it was found that there is a correlation relationship between VCAM 1 and the level of SBP and DBP. Conclusion: in patients with CAD and CKD, it is advisable to use the determination of the level of VCAM 1 to identify patients with a high risk of cardiovascular complications.
About the Authors
A. S. Samakaev
Rostov State Medical University
Russian Federation
Russian Federation
Azat S. Samakaev - postgraduate, Chair of Therapy, Rostov State Medical University.
Rostov-on-Don
S. E. Glova
Rostov State Medical University
Russian Federation
Russian Federation
Svetlana E. Glova - Cand. Sci. (Med.), Associate Professor, Chair of Therapy, Rostov State Medical University.
Rostov-on-Don
E. E. Zimoveyskaya
Rostov State Medical University
Russian Federation
Russian Federation
Elizaveta E. Zimoveyskaya - student, Rostov State Medical University.
Rostov-on-Don
L. A. Khaisheva
Rostov State Medical University
Russian Federation
Russian Federation
Larisa A. Khaisheva - Dr. Sci. (Med.), Professor, Chair of Therapy, Rostov State Medical University.
Rostov-on-Don
S. V. Shlyk
Rostov State Medical University
Russian Federation
Russian Federation
Sergey V. Shlyk - Dr. Sci. (Med.), Professor, Chair of Therapy, Rector, Rostov State Medical University.
Rostov-on-Don
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Review
For citations:
Samakaev A.S., Glova S.E., Zimoveyskaya E.E., Khaisheva L.A., Shlyk S.V. Patients with coronary heart disease and chronic kidney disease - the possibility of applying cell adhesion molecule as a predictor of disease progression. South Russian Journal of Therapeutic Practice. 2023;4(2):56-63. (In Russ.) https://doi.org/10.21886/2712-8156-2023-4-2-56-63
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